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Table 1 Comparisons of general clinical data of AD patients of different severity

From: Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer’s disease of different severity

Characteristics

Non-AD(N = 80)

Mild AD(N = 78)

Moderate AD (N = 85)

Severe AD(N = 77)

Pa

Pb

Pc

Pd

Pe

Pf

Age (year)

75.36 ± 9.32

69.36 ± 5.24

74.54 ± 6.16

76.76 ± 6.25

< 0.001

< 0.001

0.046

< 0.001

0.504

0.273

Sex (male/female)

37/43

35/43

41/44

31/46

0.754

0.627

0.344

0.875

0.876

0.52

BMI (kg/m2)

26.17 ± 2.64

25.67 ± 3.06

26.28 ± 2.67

26.32 ± 2.72

0.176

0.164

0.925

0.273

0.791

0.726

Disease duration (year)

/

3.56 ± 1.42

3.64 ± 1.53

3.78 ± 1.60

0.731

0.367

0.57

/

/

/

Education level (year)

 

7.60 ± 3.02

6.72 ± 2.64

6.78 ± 2.54

0.103

0.152

0.989

 

0.215

0.276

7.24 ± 2.72

0.432

Smoking (yes/no)

31/49

34/44

31/54

30/47

0.424

0.626

0.749

0.628

0.872

0.999

Drinking (yes/no)

36/44

32/46

42/43

36/41

0.345

0.519

0.755

0.633

0.641

0.873

Diabetes (yes/no)

33/47

29/49

41/44

30/47

0.205

0.869

0.269

0.628

0.434

0.871

Hypertension (yes/no)

35/45

26/52

32/53

24/53

0.625

0.864

0.412

0.194

0.433

0.138

SBP (mm/Hg)

129.78 ± 12.92

132.24 ± 12.51

128.92 ± 12.41

133.67 ± 15.26

0.257

0.785

0.065

0.226

0.663

0.086

DBP (mm/Hg)

78.91 ± 9.15

78.45 ± 9.36

80.62 ± 10.24

81.48 ± 9.57

0.332

0.131

0.841

0.755

0.261

0.087

TC (mmol/L)

4.27 ± 1.91

4.29 ± 1.87

4.34 ± 1.93

4.37 ± 2.02

0.985

0.964

0.994

0.947

0.815

0.75

TG (mmol/L)

1.72 ± 0.86

1.64 ± 0.78

1.76 ± 0.82

1.81 ± 0.93

0.637

0.423

0.925

0.541

0.76

0.53

LDL (mmol/L)

2.81 ± 0.63

2.78 ± 0.64

2.91 ± 0.57

2.89 ± 0.62

0.364

0.501

0.976

0.767

0.286

0.424

HDL (mmol/L)

1.18 ± 0.34

1.20 ± 0.31

1.16 ± 0.28

1.22 ± 0.34

0.689

0.915

0.437

0.7

0.68

0.462

Aβ42/Aβ40 ratio

0.27 ± 0.06

0.29 ± 0.07

0.31 ± 0.09

0.32 ± 0.09

0.118

0.022

0.481

0.055

0.001

< 0.001

  1. Note: BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; LDL: low density lipoprotein; HDL: high density lipoprotein; Aβ40: amyloid β-protein 40; Aβ42: amyloid β-protein 42. The measurement data were expressed by mean ± standard deviation or number of cases. Fisher’s exact test was employed for the comparative analysis of categorical variables. One-way ANOVA was applied for data comparisons among groups of continuous variables, followed by Tukey’s multiple comparisons test was used for the post test. P < 0.05 was indicative of statistical significance. Pa: the moderate group compared with the mild group; Pb: the severe group compared with the mild group; Pc: the severe group compared with the moderate group; Pd: the mild group compared with the Non-AD group; Pe: the moderate group compared with the Non-AD group; Pf: the severe group compared with the Non-AD group
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BMC Neurology

ISSN: 1471-2377

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