Fig. 2

Comparison of ECAS absolute scores before and after treatment initiation

A, B, C: Box plots of the ALS-specific domains before and after treatment initiation with nusinersen in SMA cohort. D, E: Box plots of the non-ALS-specific domains before and after treatment initiation with nusinersen in SMA cohort. F, G: Box plots of ECAS subscores before and after treatment initiation with nusinersen in SMA cohort. H: Box plots of ECAS total score before and after treatment initiation with nusinersen in SMA cohort. ALS: Amyotrophic lateral sclerosis; ECAS: Edinburgh Cognitive and Behavioral ALS Screen; SMA: Spinal muscular atrophy. V₀: Baseline visit before treatment initiation; V₁: Follow-up visit 14 months after treatment initiation. Box plots show median (horizontal line), inter-quartile range (boxes) and scores outside of inter-quartile range (whiskers). Calculated by Wilcoxon signed-rank test. Significance levels: * p < 0.05; ** p < 0.01; *** p < 0.001; ns: statistically not significant