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Fig. 2 | BMC Neurology

Fig. 2

From: Lymphoproliferative disorder during temozolomide therapy; a representative case of a formidable complication and management challenges

Fig. 2

Stereotactic biopsy was performed, revealing diffuse infiltration of pleomorphic cells with nuclear atypia and eosinophilic cytoplasm (A). Immunohistochemical staining for R132H IDH1 yielded negative results (B). ATRX positivity was retained (C). Negative results were obtained for H3K27M (D). Sanger sequencing of the TERT promoter revealed C250T mutation (E). Methylation-specific polymerase chain reaction demonstrated unmethylated MGMT promoter. Results for the positive control, negative control, sample and blank are displayed from left to right (F). The samples derive from the same experiment and the gels and blots were processed in parallel. The diagnosis was glioblastoma, IDH-wildtype

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BMC Neurology

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