Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury

BMC Neurology

Table 2 Comparison of neurofilament light levels between mild traumatic brain injury patients and orthopedic injury controls. The comparison between the diffusion metrics of the mTBI subgroup

	NF-L levels		FA		MD (× 10^–3)		AD (× 10^–3)		RD (× 10^–3)
Group	median [IQR]	p-value^a	mean [SD]	p-value^b	mean [SD]	p-value^b	mean [SD]	p-value^b	mean [SD]	p-value^b
all mTBI	14.28 [27.32]	0.038	0.414 [0.026]	-	0.8 [0.064]	-	1.13 [0.053]	-	0.635 [0.072]	-
CT-Negative	10.42 [8.3]	0.890	0.423 [0.023]	p < 0.001	0.78 [0.046]	0.004	1.12 [0.04]	0.021	0.612 [0.055]	0.002
CT-Positive	31.37 [48.54]	p < 0.001	0.401 [0.025]	p < 0.001	0.827 [0.073]	0.004	1.15 [0.063]	0.021	0.666 [0.081]	0.002
Complete recovery	11.16 [10.68]	0.383	0.417 [0.022]	0.145	0.792 [0.049]	0.19	1.12 [0.44]	0.291	0.625 [0.058]	0.171
Incomplete recovery	16.22 [40.97]	0.01	0.411 [0.028]	0.145	0.8 [0.071]	0.19	1.13 [0.059]	0.291	0.641 [0.08]	0.171
Orthopedic Injury Controls	10.8 [6.8]	-	-	-	-	-	-	-	-	-

^aMann-Whitney U test, p-values show the difference between Orthopedic Injury Controls and the patient groups
^bGeneralized linear model where age and sex are used as confounders, p-values represent the comparison between patient groups only
mTBI mild traumatic brain injury, CT Computed tomography, NF-L Neurofilament light, FA Fractional anisotropy, MD Mean diffusivity, AD Axial diffusivity, RD Radial diffusivity, IQR Interquartile range, SD Standard deviation

ISSN: 1471-2377