Table 1 MR results of causal links between gut microbiome and IA (P < 5 × 10–8)
From: Association of gut microbiome with risk of intracranial aneurysm: a mendelian randomization study
Classification | Nsnp | Methods | Beta | SE | OR (95%CI) | P value | Horizontal pleiotropy | Heterogeneity | F statistic | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egger intercept | SE | P value | Cochran’s Q | P value | |||||||||
Unruptured IA | |||||||||||||
Total | 12 | MR Egger | -0.08 | 0.39 | 0.92(0.43,1.96) | 0.837 | 0.03 | 0.05 | 0.495 | 14.38 | 0.156 | 87.19 | |
Weighted median | 0.12 | 0.15 | 1.12(0.83,1.52) | 0.447 | |||||||||
Inverse variance weighted | 0.17 | 0.13 | 1.19(0.92,1.54) | 0.187 | |||||||||
Weighted mode | 0.12 | 0.16 | 1.13(0.83,1.55) | 0.458 | |||||||||
Class | Melainabacteria | 1 | Wald ratio | 0.47 | 0.34 | 1.59(0.82,3.09) | 0.169 | – | – | – | – | – | – |
Family | Oxalobacteraceae | 1 | Wald ratio | 0.31 | 0.37 | 1.37(0.66,2.82) | 0.400 | – | – | – | – | – | – |
Peptostreptococcaceae | 1 | Wald ratio | 1.59 | 0.67 | 4.92(1.32,18.32) | 0.018 | – | – | – | – | – | – | |
Streptococcaceae | 1 | Wald ratio | -0.09 | 0.53 | 0.92(0.32,2.59) | 0.870 | – | – | – | – | – | – | |
unknownfamily (id:1,000,001,214) | 1 | Wald ratio | -0.08 | 0.50 | 0.92(0.34,2.47) | 0.870 | – | – | – | – | – | – | |
Genus | Eubacteriumcoprostanoligenesgroup | 1 | Wald ratio | -0.72 | 0.73 | 0.49(0.12,2.03) | 0.322 | – | – | – | – | – | – |
Eubacteriumnodatumgroup | 1 | Wald ratio | 0.13 | 0.25 | 1.14(0.70,1.87) | 0.591 | – | – | – | – | – | – | |
Ruminococcustorquesgroup | 1 | Wald ratio | 0.62 | 0.64 | 1.85(0.52,6.54) | 0.339 | – | – | – | – | – | – | |
Allisonella | 1 | Wald ratio | -0.04 | 0.23 | 0.97(0.61,1.52) | 0.878 | – | – | – | – | – | – | |
Erysipelatoclostridium | 1 | Wald ratio | -0.27 | 0.30 | 0.76(0.42,1.37) | 0.361 | – | – | – | – | – | – | |
Intestinibacter | 1 | Wald ratio | -0.37 | 0.47 | 0.69(0.27,1.73) | 0.428 | – | – | – | – | – | – | |
Oxalobacter | 1 | Wald ratio | -0.39 | 0.55 | 0.68(0.23,1.99) | 0.476 | – | – | – | – | – | – | |
RuminococcaceaeUCG013 | 1 | Wald ratio | 0.32 | 0.37 | 1.37(0.67,2.81) | 0.386 | – | – | – | – | – | – | |
Streptococcus | 1 | Wald ratio | 1.65 | 0.73 | 5.19(1.25,21.56) | 0.024 | – | – | – | – | – | – | |
unknowngenus (id:1,000,001,215) | 1 | Wald ratio | -0.08 | 0.50 | 0.92(0.34,2.47) | 0.870 | – | – | – | – | – | – | |
Order | Gastranaerophilales | 1 | Wald ratio | -0.08 | 0.50 | 0.92(0.34,2.47) | 0.870 | – | – | – | – | – | – |