Table 2 SNPs used as instrumental variables from individual bacterial abundance, the whole gut microbiome and IA GWASs (P < 5 × 10–8)
From: Association of gut microbiome with risk of intracranial aneurysm: a mendelian randomization study
Bacterial traits | SNP | Effect allele | Other allele | Gut microbiome | Unruptured IA | ||
|---|---|---|---|---|---|---|---|
Beta (SE) | P value | Beta (SE) | P value | ||||
Total | rs10805326 | G | A | 0.08(0.01) | 2.86E-08 | -0.03(0.04) | 0.477 |
rs11110281 | T | C | -0.14(0.02) | 1.47E-09 | 0.01(0.07) | 0.870 | |
rs12781711 | C | T | -0.07(0.01) | 2.33E-08 | -0.11(0.05) | 0.024 | |
rs17159861 | C | T | 0.10(0.02) | 1.10E-08 | -0.07(0.07) | 0.322 | |
rs34297067 | A | G | -0.19(0.03) | 4.41E-08 | -0.03(0.05) | 0.592 | |
rs35866622 | T | C | -0.06(0.01) | 2.23E-08 | -0.04(0.04) | 0.338 | |
rs4428215 | G | A | 0.13(0.02) | 4.76E-08 | 0.04(0.05) | 0.400 | |
rs602075 | A | G | 0.17(0.03) | 1.27E-08 | -0.01(0.04) | 0.878 | |
rs61841503 | G | A | 0.09(0.02) | 1.19E-08 | 0.15(0.06) | 0.018 | |
rs7221249 | A | G | 0.08(0.01) | 4.01E-09 | -0.03(0.04) | 0.428 | |
rs736744 | C | T | 0.12(0.02) | 2.41E-08 | 0.04(0.04) | 0.385 | |
rs9864379 | T | C | -0.16(0.03) | 4.18E-08 | -0.07(0.05) | 0.169 | |
Melainabacteria | rs9864379 | T | C | -0.16(0.03) | 4.76E-08 | -0.07(0.05) | 0.169 |
Oxalobacteraceae | rs4428215 | G | A | 0.13(0.02) | 4.76E-08 | 0.04(0.05) | 0.400 |
Peptostreptococcaceae | rs61841503 | G | A | 0.09(0.02) | 1.19E-08 | 0.15(0.06) | 0.018 |
Streptococcaceae | rs11110281 | T | C | -0.13(0.02) | 7.55E-09 | 0.01(0.07) | 0.870 |
unknownfamily (id:1,000,001,214) | rs9864379 | T | C | -0.16(0.03) | 4.18E-08 | -0.07(0.05) | 0.169 |
Eubacteriumcoprostanoligenesgroup | rs17159861 | C | T | 0.10(0.02) | 1.1E-08 | -0.07(0.07) | 0.322 |
Eubacteriumnodatumgroup | rs34297067 | A | G | -0.19(0.03) | 4.41E-08 | -0.03(0.05) | 0.592 |
Ruminococcustorquesgroup | rs35866622 | T | C | -0.06(0.01) | 2.23E-08 | -0.04(0.04) | 0.338 |
Allisonella | rs602075 | A | G | 0.17(0.03) | 1.27E-08 | -0.01(0.04) | 0.878 |
Erysipelatoclostridium | rs7221249 | A | G | 0.08(0.01) | 4.01E-09 | -0.03(0.04) | 0.428 |
Intestinibacter | rs10805326 | G | A | 0.08(0.01) | 2.86E-08 | -0.03(0.04) | 0.477 |
Oxalobacter | rs736744 | C | T | 0.12(0.02) | 2.41E-08 | 0.04(0.04) | 0.385 |
RuminococcaceaeUCG013 | rs12781711 | C | T | -0.07(0.01) | 2.33E-08 | -0.11(0.05) | 0.024 |
Streptococcus | rs11110281 | T | C | -0.14(0.02) | 1.47E-09 | 0.01(0.07) | 0.870 |
unknowngenus (id:1,000,001,215) | rs9864379 | T | C | -0.16(0.03) | 4.18E-08 | -0.07(0.05) | 0.169 |
Gastranaerophilales | rs9864379 | T | C | -0.16(0.03) | 4.18E-08 | -0.07(0.05) | 0.169 |