Fig. 4

Comparison of motor outcome scores before and after treatment initiation

A, B, C: Box plots of the motor outcome scores before and after treatment initiation with nusinersen in SMA cohort. ALSFRS-R: ALS Functional Rating Scale Revised; HFMSE: Hammersmith Functional Motor Scale Expanded; RULM: Revised Upper Limb Module; SMA: Spinal muscular atrophy V0: Baseline visit before treatment initiation; V1: Follow-up visit 14 months after treatment initiation. Box plots show median (horizontal line), inter-quartile range (boxes) and scores outside of inter-quartile range (whiskers). Calculated by Wilcoxon signed-rank test. Significance levels: * p < 0.05; ** p < 0.01; ns: statistically not significant