From: Real-world evidence on the economic implications of CGRP-mAbs as preventive treatment of migraine
Variable | Average value pre-treatment | Average value post-treatment | Difference (CI) [SD] | Difference (%) | p-value | n | Number receiving treatment, pre-treatment | post-treatment |
---|---|---|---|---|---|---|---|
Simple analgesics (tablets per month)a | 10.10 | 4.58 | 5.53 (-0.10–11.15) [21.60] | 54.7% | 0.054 | 59 | 30 | 26 |
Antiemetic tablets (tablets per month) | 2.69 | 0.90 | 1.80 (0.82–2.77) [3.74] | 66.7% | 0.000 | 59 | 26 | 14 |
Antiemetic injections (injections per month) | 0 | 0.02 | + 0.02 (-0.05–0.02) [0.130] | - | 0.322 | 59 | 0 | 1 |
Treo (tablets per month)b | 7.25 | 3.75 | 3.51 (0.90–6.11) [10.00] | 48.4% | 0.001 | 59 | 25 | 25 |
Triptan tablets (tablets per month) | 7.64 | 4.15 | 3.49 (2.21–4.78) [4.94] | 45.7% | 0.000 | 59 | 40 | 38 |
Triptan melt tablets (melt tablets per month) | 1.81 | 0.76 | 1.05 (-0.03–2.13) [4.15] | 57.9% | 0.057 | 59 | 10 | 11 |
Triptan nose spray (uses per month) | 0.31 | 0.31 | 0 (-0.34–0.34) [1.30] | 0% | 1.000 | 59 | 2 | 3 |
Triptan injections (injections per month) | 0.02 | 0.02 | 0 (-0.05–0.05) [0.19] | 0% | 1.000 | 59 | 1 | 1 |
Beta-blockers (tablets per month) | 10.42 | 1.61 | 8.81 (3.30–14.33) [21.16] | 85.6% | 0.002 | 59 | 14 | 6 |
Antihypertensive (other than beta-blockers, tablets per month) | 15.58 | 7.41 | 8.17 (3.08–13.26) [19.53] | 52.4% | 0.002 | 59 | 24 | 12 |
Botulinum toxin (treatment cycles per month) | 0.32 | 0.10 | 0.22 (0.01–0.43) [0.81] | 68.8% | 0.041 | 59 | 17 | 3 |
Anti-depressants (tablets per month) | 9.73 | 5.66 | 4.07 (-0.81–9.95) [22.56] | 41.8% | 0.171 | 59 | 14 | 8 |
Anti-epileptics (tablets per month) | 13.44 | 2.63 | 10.81 (4.88–16.75) [22.77] | 80.5% | 0.000 | 59 | 17 | 3 |
GP visits (visits per year) | 2.57 | 1.76 | 0.81 (0.13–1.49) [2.57] | 32.7% | 0.020 | 58 | 37 | 26 |
Specialist visits (visits per year) | 1.97 | 1.12 | 0.85 (0.17–1.53) [2.61] | 43.1% | 0.015 | 59 | 31 | 20 |
Outpatient visits (visits per year) | 4.07 | 3.51 | 0.56 (-1.41–2.53) [7.56] | 13.8% | 0.572 | 59 | 43 | 54 |
ER visits (visits per year) | 0.59 | 0.25 | 0.34 (0.05–0.63) [1.09] | 57.1% | 0.020 | 59 | 11 | 6 |
Cost of hospitalisationc (cost of hospitalisation per year) | 5,780 | 801 | 4,979 (1,141–8,816) [14,725] | 13.9% | 0.012 | 59 | 14 | 3 |