Table 4 Dose modification in case of renal insufficiency
Glomerular filtration rate (GFR) in ml/min | Dosage modification in mg | Administration interval |
|---|---|---|
80 − 60 | no dosage modification | |
60 − 50 | no dosage modification | |
50 − 30 | 100 mg | 1-1-0 No increase in non-responders |
30 − 20 | 100 mg | 1-0-0 no increase in non-responders |
20 − 10 | 100 mg | 1-0-0 no increase in non-responders |
< 10 or hemodialysis | excluded from trial |