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Fig. 1 | BMC Neurology

Fig. 1

From: An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI

Fig. 1

1a. Imaging processing protocol of NM-MRI. (a) showed a T2-weighted sagittal view of a healthy 40-year-old man. And the blue frame was the initial scanning location and vertical to the bottom of fourth ventricle, ranging from splenium of the corpus callosum to the inferior edge of pons. The high signal areas of (b),(d) and (c),(e) was the coronal images of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) on NM-MRI of a healthy 23-year-old man. The blue circles were the measurement ROIs.SN-a, SN-c, SN-p and SCP in (d) indicate anterior part of SNpc, central part of SNpc, posterior part of SNpc and superior cerebellar peduncle. PT in (e) indicates pontine tegment (PT). 1b Sample images of comparison of CNR of SNpc and LC between groups (1),(2) were SNpc and LC of a healthy 40-year-old male. (3),(4) were SNpc and LC of a 49-year-old male with early PD(H&Y stage:II). (5),(6) were SNpc and LC of a 64-year-old female with progressive PD(H&Y stage:IV)

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BMC Neurology

ISSN: 1471-2377

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