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Table 2 Comparison of CNR of SNpc and LC between groups

From: An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI

Part

Healthy Subjects(N = 10)

Early PD(N = 10)

Progressing PD(N = 11)

P value

SNpc

    

 anterior

 central

 posterior

20.14 ~ 33.55% (27.34% ± 4.90%)

17.12 ~ 31.43% (24.25% ± 4.38%)

14.10 ~ 22.55% (17.88% ± 3.08%)

9.37 ~ 30.38% (20.00% ± 6.60%)

8.21 ~ 25.87% (17.45% ± 5.42%)

6.15 ~ 17.19% (11.98% ± 3.61%)

11.64 ~ 20.20% (16.17% ± 2.92%)

8.88 ~ 21.99% (14.23% ± 3.67%)

3.40 ~ 16.31% (10.17% ± 3.59%)

P*<0.05 P1 = 0.011 P2 < 0.01 P3 = 0.021

P*<0.05 P1 = 0.006 P2 < 0.01 P3 = 0.028

P*<0.05 P1 = 0.001 P2 < 0.01 P3 = 0.043

LC

8.14 ~ 18.42% (11.81% ± 3.16%)

2.35 ~ 12.82% (7.74% ± 3.63%)

2.60 ~ 13.54% (6.83% ± 3.36%)

P*<0.05 P1 = 0.015 P2 < 0.01 P3 = 0.051

  1. P*: Analysis of variance (ANOVA); P1: Healthy Subjects versus Early PD with t-test; P2: Healthy Subjects versus Progressing PD with t-test; P3: Early PD versus Progressing PD with t-test