Fig. 1From: Core protocol development for phase 2/3 clinical trials in the leukodystrophy vanishing white matter: a consensus statement by the VWM consortium and patient advocatesSchematic overview of the core protocol. A Venn diagram to show that the core protocol is the common template across all trial protocols. B Fictitious impression of parallel and consecutive ongoing trials using the core protocol and contributing to a shared pool of controls. The shared pool of controls, reduces the total number of patients needed to be randomized to placebo. Abbreviations: IMP = investigational medicinal productBack to article page