Ticagrelor plus aspirin in patients with minor ischemic stroke and transient ischemic attack: a network meta-analysis

Table 1 Characteristics of studies included in the meta-analysis

Study	teatment vs control	Loading dose	country	total	Female	treatment window form onset	treatment duration	Follow-up	Median age	Asian	NIHSS	ABCD2	Lost
CHANCE-2 2021 [16]	A + T vs A + C(A100mg,T90mg bid,C75mg	T180mg,A300mg,C300mg	China	6412	2170	24 h	21d	90d	UNK	6412	≤ 3	≥ 4	0
THALES 2020 [14]	A + T vs A (T90 bid,A75-100 mg)	T180mg,A300-325 mg)	28 countries	11,016	4279	24 h	30d	30d	65	4729	≤ 5	≥ 6	UNK
PRINCE 2019 [15]	A + T vs A + C(A100mg,T90mg bid,C75mg	T180mg,A100-300 mg,C300mg	China	675	181	24 h	21d	90d	61	675	≤ 3	≥ 4	12
POINT 2018 [6]	A + C vs A(C 75 mg, A50-325 mg)	C 600 mg		4881	2195	12 h	90d	90d	65	144	≤ 3	≥ 4	199
SOCRATES 2016 [13]	T vs A (T90bid,A100mg)	T180mg,A300mg	33countries	13,199	5483	24 h	90d	90d	66	3906	≤ 5	≥ 4	2
CHANCE 2013 [5]	A + C vs A(C 75 mg, A50-325 mg)	C300mg	China	5170	1750	24 h	21d	90d	63	5170	≤ 3	≥ 4	36
FASTER 2007 [7]	A + C vs A(C 75 mg, A81mg)	C300mg A162mg	Canada	392	UNK	24 h	90d	90d	UNK	0	≤ 3	NA	UNK

A aspirin, C clopidogrel, T ticagrelor, h hour, d day, UNK unknown, NIHSS National Institutes of Health Stroke Scale

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