Is coronary artery calcium an independent risk factor for white matter hyperintensity?

BMC Neurology

Table 3 Independent risk factors associated with white matter hyperintensity

	Univariate	P Value	Multivariate	P Value
	OR (95% CI)	P Value	Adjusted OR (95% CI)	P Value
Age, y	1.169 (1.130–1.210)	0.001	NA	NA
Sex, male	1.180 (0.752–1.852)	0.322	NA	NA
Body mass index (kg/m²)	1.150 (1.066–1.240)	0.001	NA	NA
Hypertension	2.435 (1.540–3.850)	0.001	1.815 (1.042–3.162)	0.035
Diabetes	2.315 (1.455–3.684)	0.001	2.183 (1.247–3.822)	0.006
Smoking	2.887 (1.786–4.667)	0.001	NA	NA
Alcohol	0.229 (0.138–0.379)	0.001	NA	NA
Heart disease	1.805 (0.962–3.388)	0.066	NA	NA
Hypercholesterolemia	1.391 (0.768–2.517)	0.276	NA	NA
CACS	1.005 (1.004–1.006)	0.001	1.005 (1.004–1.006)	0.001

Note: WMH, white matter hyperintensity; CACS, coronary artery calcium score, NA, not available as the variable was not included in the multivariate logistic regression; Bold values indicate that the variables are significant with P < 0.05.

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