Fig.

(A1) Sagittal T2-weighted MRI of case one’s cervical and thoracic spine demonstrating longitudinally extensive T2 hyperintensity from C2-T5 with localized spinal cord edema. (A2) Sagittal T2-weighted MRI of case one’s cervical and thoracic spine 8 months later, demonstrating longitudinally extensive T2 hyperintensity from C2-T4 with localized spinal cord edema. (A3) Sagittal T1 gadolinium enhanced MRI of case one’s cervical and thoracic spine at 8 months from initial symptom onset, demonstrating contrast enhancement in the cervical portions of her spinal cord. (B) Axial T2-FLAIR brain MRI of case one, showing periventricular hyperintensities (red arrows) with no significant other parenchymal abnormality. (C1), Axial T2-FLAIR optic nerve and brain MRI of case two demonstrating hyperintensity in the optic nerves, more evident in the left optic nerve (blue arrow). (C2), (C3) Axial and coronal T1-gadolinium enhanced optic nerve and brain MRIs of case two, demonstrating contrast enhancement in both optic nerves, more extensive in her left optic nerve (yellow and red arrows). (D1) Sagittal T2-weighted MRI of case two’s spinal cord, demonstrating normal spinal cord signal