Neutrophil to lymphocyte ratio in parkinson’s disease: a systematic review and meta-analysis

BMC Neurology

Table 2 GRADE¹ Evidence Profile for cohort studies of the neutrophil to lymphocyte ratio in Parkinson’s disease

Certainty assessment							No of patients		Certainty	Importance
№ of studies	Study design	Risk of bias²	Inconsistency³	Indirectness	Imprecision⁵	Publication bias⁶	Participants, n	Cases, n	Certainty	Importance
20	observational studies	not serious	very serious	not serious	not serious	none	6071	3584	⨁◯◯◯ Very low	CRITICAL

¹Grading of Recommendations Assessment, Development and Evaluation
²Risk of bias based on Newcastle-Ottawa Scale
³When I² was < 30% inconsistency considered as Not serious limitation, > 50 considered as serious and more than 75% considered as very serious limitation
⁵Serious limitations when there was fewer than 400 participants for each outcome and very serious limitations when there was fewer than 300 participants for each outcome
⁶Funnel plot revealed no asymmetry; neither test of publication bias approached P < 0.10

ISSN: 1471-2377