| | Univariable | | Multivariable |
|---|
| | Estimate | p | Estimate | 95% CI | p |
|---|
Age | 0.024 | 0.017* | 0.023 | 0.006–0.040 | 0.008** |
Sex (F) | 0.074 | 0.794 | -0.365 | -0.861–0.132 | 0.148 |
Onset-to-sample time | 1.023 | < 0.001*** | 0.895 | 0.369–1.422 | 0.001** |
Recurrent disease | 0.307 | 0.433 | 0.233 | -0.432–0.898 | 0.489 |
Lesion length | 0.335 | < 0.001*** | 0.297 | 0.176–0.418 | < 0.001*** |
lnNLR | 0.957 | < 0.001*** | 0.484 | 0.031–0.937 | 0.037* |
- Repeated EDSS assessments at each visit were set as the outcome, and were analyzed using linear mixed-effects regression model with subject-specific random intercept and slope for each subject. Variables included in the multivariable model (age, sex, onset-to-sample time, recurrent disease, MRI lesion length, lnNLR) were selected from significant variables in the univariable analysis as well as adjusted variables
- EDSS expanded disability status scale, CI confidence interval, F female sex (compared to male), lnNLR natural log-transformed neutrophil-to-lymphocyte ratio
- *p < 0.05; **p < 0.01, ***p < 0.001
