Fig. 3

Depression and Anxiety Symptom Severity, Comparison Between Matched Non-MS Controls and RRMS+LF and RRMS+HF. Note: For the set of tests shown in the table, the corrected α level was 0.050 for the omnibus test and for comparisons between RRMS+LF and RRMS+HF and between RRMS+HF and controls; the corrected alpha level was 0.028 for comparisons between RRMS+LF and controls. Differences remained statistically significant after adjusting the alpha level. GAD-7, Generalized Anxiety Disorder-7; HF, high fatigue; LF, low fatigue; MS, multiple sclerosis; PHQ-9, Patient Health Questionnaire-9; RRMS, relapsing-remitting multiple sclerosis. PHQ-9 score cutoffs of 0-4 (mild/minimal), 5-9 (mild), 10-14 (moderate), 15-19 (moderately severe), and 20-27 (severe); GAD-7 score cutoffs of 0-4 (mild/minimal), 5-9 (mild), 10-14 (moderate), 15-21 (severe). ^ap<0.001 for comparison to matched non-MS controls; ^bp<0.001 for comparison to RRMS+LF