Exploring humanistic burden of fatigue in adults with multiple sclerosis: an analysis of US National Health and Wellness Survey data

Table 3 Health-related quality of life, comparisons between matched non-MS controls and RRMS+LF and RRMS+HF

	A. Matched Non-MS Controls		B. RRMS+LF (MFIS-5=0-14)		C. RRMS+HF (MFIS-5=15+)		p Value
	(N=1,494)		(N=375)		(N=123)		p Value
	Mean/n	SD/%	Mean/n	SD/%	Mean/n	SD/%	Omnibus	A vs B	A vs C	B vs C
SF-36v2
MCS Score	47.50	11.52	47.09	11.25	35.81	11.04	<0.001	0.539	<0.001	<0.001
PCS Score	49.56	10.09	42.31	9.81	31.97	8.08	<0.001	<0.001	<0.001	<0.001
SF-6D Utility Score	0.72	0.14	0.67	0.12	0.53	0.09	<0.001	<0.001	<0.001	<0.001
EQ-5D-5L
EQ-5D-5L Index Score	0.82	0.16	0.75	0.16	0.58	0.19	<0.001	<0.001	<0.001	<0.001
EQ-5D-5L VAS Score	74.32	22.26	65.30	22.90	45.54	22.41	<0.001	<0.001	<0.001	<0.001
PHQ-9 Score	4.85	6.17	5.30	5.14	12.64	6.77	<0.001	0.200	<0.001	<0.001
Depression Severity (PHQ-9)
None/minimal (0-4)	952	63.72	201	53.60	16	13.01	<0.001	<0.001	<0.001	<0.001
Mild (5-9)	281	18.81	108	28.80	24	19.51
Moderate (10-14)	122	8.17	39	10.40	32	26.02
Moderately Severe (15-19)	76	5.09	21	5.60	27	21.95
Severe (20-27)	63	4.22	6	1.60	24	19.51
GAD-7 Score	3.69	4.95	3.36	4.29	7.94	6.45	<0.001	0.232	<0.001	<0.001
Anxiety Severity (GAD-7)
None/minimal (0-4)	1,037	69.41	263	70.13	46	37.40	<0.001	0.125	<0.001	<0.001
Mild (5-9)	249	16.67	75	20.00	29	23.58
Moderate (10-14)	131	8.77	24	6.40	23	18.70
Severe (15-21)	77	5.15	13	3.47	25	20.33

For the set of tests shown in the table, the corrected alpha level was 0.050 for the omnibus test and for comparisons between RRMS+LF and RRMS+HF and between RRMS+HF and controls; the corrected alpha level was 0.028 for comparisons between RRMS+LF and controls. Differences remained statistically significant after adjusting the alpha level. EQ-5D-5L Euroqol-5 dimensions-5 levels, GAD-7 Generalized anxiety disorder-7, HF High fatigue, LF Low fatigue, MS Multiple sclerosis, MCS Mental component summary, PCS Physical component summary, PHQ-9 Patient health questionnaire-9, RRMS Relapsing remitting multiple sclerosis, SD Standard deviation, SF-36v2 36-Item short form health survey (version 2), SF-6D Short form-6 dimensions, VAS Visual analogue scale

ISSN: 1471-2377