Exploring humanistic burden of fatigue in adults with multiple sclerosis: an analysis of US National Health and Wellness Survey data

Table 4 Humanistic outcomes related to fatigue in RRMS, adjusted results

	β	SE	Exp(β)	95% CI		p Value
	β	SE	Exp(β)	LCL	UCL	p Value
SF-36v2
MCS Score^a	−1.157	0.088	NA	−1.330	−0.983	<0.001
PCS Score^a	−1.262	0.071	NA	−1.401	−1.123	<0.001
SF-6D Utility Score^a	−0.017	0.001	NA	−0.018	−0.015	<0.001
EQ-5D-5L
EQ-5D-5L Index Score^a	−0.016	0.001	NA	−0.019	−0.013	<0.001
EQ-5D-5L VAS Score^a	−2.263	0.194	NA	−2.643	−1.884	<0.001
Depression
PHQ-9 Score^a	0.117	0.008	1.124	0.101	0.133	<0.001
Moderate to Severe Depression Symptoms^b	0.270	0.031	1.309	1.233	1.391	<0.001
Anxiety
GAD-7 Score^a	0.114	0.011	1.121	0.092	0.136	<0.001
Moderate to Severe Anxiety Symptoms^b	0.227	0.034	1.255	1.173	1.342	<0.001
PDQ-5 Score^a	0.726	0.030	NA	0.666	0.785	<0.001
Overall Treatment Satisfaction^a,c	−0.068	0.0197	NA	−0.106	−0.029	0.001

For the set of tests shown in the table, the corrected α level was 0.050; all results remained statistically significant
β parameter estimate, CCI Charlson comorbidity index, CI confidence interval, EQ-5D-5L Euroqol-5 Dimensions-5 Levels, Exp exponential, GAD-7 Generalized Anxiety Disorder-7, LCL lower confidence limit, MCS Mental Component Summary, NA not applicable, PCS Physical Component Summary, PDQ-5 Perceived Deficits Questionnaire-5, PHQ-9 Patient Health Questionnaire-9, RRMS relapsing-remitting multiple sclerosis, SE standard error, SF-36v2 36-Item Short Form Health Survey (version 2), SF-6D Short Form-6 Dimensions, UCL upper confidence limit, VAS visual analogue scale
^aGeneralized linear models controlling for age, race, sex, and CCI score; N=498
^bBinary logistic regression model, controlling for age, sex, race, CCI score; N=498
^cn=175 treated

ISSN: 1471-2377