Primary endpoints: |
1. 30% reduction in attack frequency with TENS and ONS |
2. Safety in ONS and TENS treatment |
Secondary endpoints |
1. Participant’s assessment of treatment effect evaluated by PGIC-score |
2. Treatment efficacy of burst versus tonic ONS as a preventive treatment for chronic cluster headache |
3. Feasibility of TENS as a predictor for the outcome of ONS treatment |
4. 30% reduction in pain intensity |
5. Quality of life as evaluated with the EuroQoL-5D questionnaire |
6. Reduction in background headache |
7. Self-reported sleep quality |
8. Symptoms of anxiety and depression as evaluated by HADS |