Multimodal agility-based exercise training (MAT) versus strength and endurance training (SET) to improve multiple sclerosis-related fatigue and fatigability during inpatient rehabilitation: a randomized controlled pilot and feasibility study [ReFEx]

Table 3 A priori progression requirements [14] and results

Requirement	Results
quantitative
1. Adherence
Average of at least 18 therapy sessions completed during the stay per group	+ MAT: 22.7 (12–33) + SET: 30.8 (18–38)
2. Recruitment
4 participants/month < 25% non-eligible pwMS < 10% eligible but unwilling to participate	− 1.8/month − 74% non-eligible − 12%
3. Retention
T₁ > 90% per group T₂ > 80% per group	+ 91% (both groups) + 82% (MAT) − 73% (SET)
4. Time
> 80% able to complete all baseline assessments within the first 3 days of therapy	− 50%
qualitative
5. Interviews
Statements indicate that the interventions and study processes are acceptable	There were no major acceptability issues. Still, some adaptations to the study protocol were identified and will be reported separately.

Adherence data is presented as mean (min-max); + = requirement fulfilled; - = requirement not fulfilled; MAT = multimodal agility-based exercise training; pwMS = persons with multiple sclerosis; SET = strength and endurance training; T₁ = discharge; T₂ = one-week post-discharge

ISSN: 1471-2377