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Table 2 First symptomatic AD treatment in newly diagnosed AD dementia patients from a major U.S. health plan and CPRD database

From: Patterns of use of symptomatic treatments for Alzheimer's disease dementia (AD)

 

Major U.S. health plan

CPRD

N

7,561b

4,470

Monotherapy

 Donepezil

5250a (69.4)

2,710 (60.6)

 Rivastigmine

252 (3.3)

227 (5.1)

 Galantamine

48 (0.6)

221 (4.9)

 Memantine

1,447 (19.1)

1,265 (28.3)

Combination therapy

 Donepezil + Memantine

518 (6.9)

37 (0.8)

 Other

46 (0.7)

10 (0.2)

  1. a < 1% of patients using Donepezil as their first therapy used the 23mg/day dose
  2. bMonotherapy is defined as one anti-dementia drug and duration of therapy > 21 days. If monotherapy lasts <  = 21 days, these patients were counted as trial/uncertain category (n = 76)