Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy

Table 4 Leukocyte Differentially Expressed Genes (DEGs) comparing low and high temporal lobe epilepsy seizure frequency patients

Genes	Fold Change (FC)	FDR^a	p-value
Upregulated in Low compared to High seizure frequency TLE
NCF2	4.044962	0.002835	4.83 × 10^–6
HMOX1	3.912648	0.001222	1.04 × 10^–6
RHOB	3.370525	0.023331	0.000122
FCGR2A	3.355795	0.012951	4.92 × 10^–5
PRKCD	3.068704	0.010221	3.32 × 10^–5
RAC2	3.041648	0.034416	0.00029
TLR1	2.869047	0.035484	0.000348
CHP1	2.769877	0.008084	2.15 × 10^–5
TNFRSF1A	2.732864	0.023331	0.00013
IFNGR1	2.732414	0.016528	6.99 × 10^–5
LYN	2.525921	0.031583	0.00023
MYD88	2.520108	0.043643	0.000496
CASP1	2.443742	0.035484	0.00033
Upregulated in High compared to Low seizure frequency TLE
TYMS	444.9515	0.000136	9.58 × 10^–9
AK1	59.63923	0.009746	2.93 × 10^–5
F2R	51.47103	0.015462	6.43 × 10^–5
GNB5	22.58811	0.032269	2.62 × 10^–4

FC indicates fold change of leukocyte gene upregulation in low versus high seizure frequency TLE. ^aFDR False Discovery Rate. (p < 0.001, FC > 2.0, FDR < 0.05)

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