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Fig. 1 | BMC Neurology

Fig. 1

From: Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases

Fig. 1

Distribution of cerebrospinal fluid (CSF) containing the tracer in the brain over time for each patient. (A) Panel shows T1-weighted MR images (axial and coronal planes) of the four participants before the intrathecal administration of the gadolinium-based contrast agent (Pre-Gd), and at different time points after the contrast administration (1.5-2 h, 5–6 and 48 h). (B) Panel shows the enrichment of the CSF measured as percentage T1 signal increase. (C) Panel shows the enrichment of the brain tissue measured as percentage of T1 signal increases (the CSF signal was subtracted before the calculations were performed). Scale bar for voxel intensity is shown in B and C

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