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Table 1 Demographic and clinical data, scores for the cognitive tests and biomarkers analyses. MMSE: Mini Mental State Examination; RBANS-DMI: Repeatable Battery for the Assessment of Neuropsychological Status-Delayed Memory Index. Protein expression levels of biomarkers in the CSF of participants. Cut-off points to define positivity for AD: Aβ1−42 < 638 pg/mL; total (t)-tau > 404 pg/mL; p-tau 181 > 52.1 pg/mL; t-tau/ Aβ42 > 0.784; Aβ1−42/Aβ1−40 < 0.068. [9]

From: Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases

Participants

T001

T002

T003

T004

Age (years)

74

70

73

79

Sex

Male

Female

Female

Male

Education (years)

8

8

8

12

MMSE

21

22

25

15

RBANS-DMI

56

93

48

40

CDR

CSF Aβ1−42 (pg/mL)

0.5

370

0.5

239

0.5

335

2.0

216

CSF p-tau 181 (pg/mL)

133.8

161.9

101.1

88

CSF T-tau (pg/mL)

734

848

661

568

1−42/Aβ1−40

0.046

0.034

0.029

0.03

T-tau/Aβ1−42

1.984

3.548

1.862

2.63