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Fig. 1 | BMC Neurology

Fig. 1

From: Adjunctive tonic motor activation enables opioid reduction for refractory restless legs syndrome: a prospective, open-label, single-arm clinical trial

Fig. 1

Participant disposition. During TOMAC treatment, opioid dose was reduced iteratively in three consecutive step-downs – each lasting 2–3 weeks – until RLS symptoms increased (CGI-I > 5) or the participant was discontinued for other reasons. Abbreviations: CGI-I, clinical global impression of improvement; MME, morphine milligram equivalent; TOMAC, tonic motor activation

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BMC Neurology

ISSN: 1471-2377

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