Fig. 2

Opioid dose reduction. A Comparison of daily opioid dose (MME) for each participant (n = 20) at baseline and at the maximum successful reduction during TOMAC treatment. Each gray line represents one participant; black line represents average across all participants. B Histogram of maximum successful daily MME reduction from baseline. C Relationship between baseline MME and maximum successful daily MME reduction from baseline. Each point represents one participant. D Histogram of maximum successful daily MME reduction from baseline, expressed as percentage of baseline dose. In all representations, the 5 participants who did reduce opioid dose but were not able to tolerate the reduction are scored as 0 MME reduction. Abbreviations: MME, morphine milligram equivalent; TOMAC, tonic motor activation