Table 1 Participant characteristics during Insight 46 phase 1 (complete), phase 2 (complete), and phase 3 (underway at the time of publication, numbers in table are accurate as of June 2023)
Phase 1 | Phase 2 | Phase 3 (as of June 2023) | |||||
|---|---|---|---|---|---|---|---|
Clinic visit in London | n (%) | Median age in yrs (min–max) | n (%) | Median age in yrs (min–max) | n (%) | Median age in yrs (min–max) | |
Male | 256 (51.0) | 70.7 (69.2–71.7) | 217 (52.5) | 72.9 (71.9–74.7) | 131 (52.4) | 76.5 (75.5–77.3) | |
Female | 246 (49.0) | 70.7 (69.3–71.8) | 196 (47.5) | 73.0 (72.0–74.1) | 119 (47.6) | 76.4 (75.5–77.3) | |
Total | 502 (100.0) | 70.7 (69.2–71.8) | 413 (100.0)a | 73.0 (71.9–74.7) | 250 completed, target n = 750 | 76.4 (75.5–77.3) | |
Aβ PET/MRI scan | n (%) | Median age in yrs (min–max) | n (%) | Median age in yrs (min–max) | n (%) | Median age in yrs (min–max) | |
Male | 241 (51.2) | 70.7 (69.2–71.8) | 191 (51.8) | 72.9 (71.9–74.7) | 53 (47.7) | 76.3 (75.6–77.3) | |
Female | 230 (48.8) | 70.7 (69.3–71.9) | 178 (48.2) | 73.0 (72.0–74.6) | 58 (52.3) | 76.3 (75.6–77.3) | |
Total | 471 (100.0) | 70.7 (69.2–71.9) | 369 (100.0) | 73.0 (71.9–74.7) | 111b completed, target n = 500 | 76.3 (75.6–77.3) | |
Tau PET/MRI scan | n/a | n/a | n (%) | Median age in yrs (min–max) | |||
Male | 63 (57.8) | 76.5 (75.6–77.3) | |||||
Female | 46 (42.2) | 76.7 (75.6–77.3) | |||||
Total | 109 completed, target n = 250 | 76.6 (75.6–77.3) | |||||
Lumbar punctures | n/a | n (%) | n (%) | ||||
Male | 85 (63.4) | 70 (61.4) | |||||
Female | 49 (36.6) | 44 (38.6) | |||||
Total | 134 (100.0)c | 114 (100.0)d | |||||
Remote research assessments via computer | n/a | n (%) | n/a | ||||
Male | 11 (55.0) | ||||||
Female | 9 (45.0) | ||||||
Total | 20 (100.0) | ||||||
Remote research assessments via telephone | n/a | n (%) | n/a | ||||
Male | 5 (55.6) | ||||||
Female | 4 (44.4) | ||||||
Total | 9 (100.0) | ||||||