Table 2 Assessments administered during each phase of Insight 46

 12-Item Face—Name Associative Memory Exam (FNAME)

[10, 18, 21]

✓ (version A)

✓ ^a (version A)

✓ ^a (version A)

–

✓ ^a (version B)

 15-Item Word List Learning Task

[11, 22]

–

–

–

–

✓ ^a

 Adult Memory and Information Processing Battery (AMIPB) Complex Figure

[23]

–

✓ ^a (AMIPB figure version 1)

✓ ^a (AMIPB figure version 1)

–

✓ ^a (AMIPB figure version 2)

 Choice Reaction Time/Response Inhibition

[10, 19]

✓

✓

‒

‒

✓ (inhibition condition removed, choice reaction time still administered)

 Graded Naming Test (GNT)

[24]

–

✓

✓

–

✓

 Instructionless Eye Tracking

[25]

✓ (first administered in Feb 2017)

✓

–

–

–

 Irrelevant Distractor Task

[10]

✓

–

–

–

–

 Visual Search Speed Task

[11, 22]

–

–

–

–

✓

 Visual Short-term Memory Binding

[10, 26]

✓

✓

–

–

✓

 Visuomotor Integration Circle-Tracing Task with Concurrent (Dual-Task) Serial Subtraction

[10, 27]

✓

✓

–

–

✓ (plus single-task circle tracing and single-task serial subtraction)

 Wechsler Abbreviated Scale of Intelligence (WASI) – Matrix Reasoning

[10, 18]

✓

✓

✓

–

✓

 Wechsler Adult Intelligence Scale-Revised (WAIS-R) – Digit-Symbol Substitution Test (DSST)

[10, 18]

✓

✓

✓

✓

✓

 Wechsler Memory Scale – Revised (WMS-R) Logical Memory Recall IIa (Immediate and Delayed)

[10, 18]

✓

✓

✓

✓

✓

 Wechsler Memory Scale (WMS) Digit Span Forward and Backward

[28]

–

–

–

–

✓

 Anoto AP-701 Digital Pen

[29]

–

–

–

–

✓ (DSST, AMIPB complex figure, MMSE)

 Audio Recordings

[30]

–

✓ (GNT)

✓ (GNT)

–

✓ (GNT, WMS-R Logical Memory Recall IIa Immediate and Delayed, Serial Subtraction)

 Empatica

–

✓

–

–

✓

 AD8 Dementia Screening Interview

[10, 31,32,33]

✓

✓

✓

✓

✓

 Clinical Dementia Rating (CDR) Scale

[34, 35]

–

✓

✓

✓

✓

 Delirium Questionnaire

–

✓

✓

✓

✓

 History of Neurological Diagnosis (Personal and Family)

[10, 33]

✓

✓

✓

✓

✓

 Mini Mental State Examination (MMSE)

[10, 18, 36]

✓

✓

–

–

✓

 MyCog

[10, 33]

✓

✓

✓

✓

✓

 Subjective Cognitive Decline Questions

[10, 33]

✓

✓

✓

✓

✓

 Blood Pressure

[10, 37, 38]

✓ (lying, standing)

✓ (sitting, lying, standing)

–

–

✓ (sitting, lying, standing)

 Bradykinesia Akinesia Incoordination (BRAIN) Tap Test

[10]

✓

✓

–

–

✓

 Self-paced Gait in Isolation and with Cognitive Task

[10]

✓

✓

–

–

✓

 Walking Speed

[39]

–

–

–

–

✓

 Height

[10, 11]

✓

✓

–

–

✓

 Weight

[10, 11]

✓

✓

✓ (estimated)

✓ (estimated)

✓

 Hip and Waist Circumference

[11, 40]

–

–

–

–

✓

 Bioimpedance

–

–

–

–

✓

 Unified Parkinson’s Disease Rating Scale (UPDRS) – Part III: Motor Examination

[10]

✓

✓

✓ (partial)

–

✓

 6-Minute Stepper Test

[13, 41]

–

✓

–

–

✓

 Grip Strength

[11, 42]

–

–

–

–

✓

 Chair Rises

[11, 43]

–

–

–

–

✓

 Standing and Walking Balance

[11, 44]

–

–

–

–

✓

 Spirometry

[45, 46]

–

–

–

–

✓

 Actigraphy

–

✓

✓

✓

✓

 Glucose Monitor

[47]

–

–

–

–

✓

 Pure Tone Audiometry

[10, 48]

✓

–

–

–

–

 Word in Noise

[10]

✓

–

–

–

–

 University of Pennsylvania Smell Identification Test (UPSIT)

[10, 49]

✓

–

–

–

–

 Portable Eye Examination Kit (PEEK)

[10]

✓

–

–

–

–

 Spoons Taste Test

[50]

–

✓

–

–

–

 Dental Hygiene

[10]

✓

–

–

–

–

 Handedness

[10]

✓

–

–

–

–

 State-Trait Anxiety Inventory (STAI)

[10, 33]

✓

✓

✓

✓

✓

 Question About Movement in Sleep

[10]

✓

–

–

–

–

 Epworth Sleepiness Scale (ESS)

[51, 52]

–

✓

✓

✓

✓

 Pittsburgh Sleep Quality Index (PSQI)

[53]

–

✓

✓

✓

✓

 REM Sleep Behaviour Disorder Questionnaire (RSBDQ)

[54]

–

✓

✓

✓

✓

 Perseverative Thinking Questionnaire (PTQ)

[55]

–

✓

✓

✓

✓

 Head Injury Questionnaire

[56]

–

✓

✓

✓

✓

 General Health Questionnaire (GHQ)-28

[11, 57, 58]

–

–

–

–

✓

 Blood – Haematology and Biochemistry

[59]

✓

–

–

–

✓

 Blood – DNA

✓

–

–

–

–

 Blood – RNA

–

✓

–

–

✓

 Blood – Cell Lines

[60, 61]

–

✓

–

–

✓

 Blood – Biomarkers

[16, 62]

✓

✓

–

–

✓

 Urine – Biomarkers

✓

✓

–

–

✓

 Urine – Spot Urine Sample

[11]

–

✓

–

–

–

 Cerebrospinal Fluid

[62]

–

✓

–

–

✓

 2D and 3D Echocardiography

[11, 13]

–

✓

–

–

✓

 Carotid Intima-Media Thickness

[11, 13]

–

✓

–

–

✓

 Carotid Femoral Pulse Wave Velocity (PWV)

[11, 13]

–

✓

–

–

✓

 Pulse Wave Analysis (PWA) – Central Blood Pressure

[11, 13]

–

✓

–

–

✓

 Electrocardiogram (ECG)

[11, 13]

–

✓

–

–

✓

 Functional Near-Infrared Spectroscopy (fNIRS)

[13]

–

✓

–

–

✓

 Positron Emission Tomography (PET)

[63]

[¹⁸F]florbetapir (Aβ)

[¹⁸F]florbetapir (Aβ)

–

–

[¹⁸F]florbetaben (Aβ) or [¹⁸F]MK6240 (tau)

 Brain Magnetic Resonance Imaging (MRI)

[63, 64]

✓

✓

–

–

✓

 Dual-energy X-ray Absorptiometry (DXA)

[11, 40]

–

–

–

–

✓

 Optical Coherence Tomography (OCT)

–

–

–

–

✓