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Fig. 2 | BMC Neurology

Fig. 2

From: Modification of the height of a weight drop traumatic brain injury model that causes the formation of glial scar and cognitive impairment in rats

Fig. 2

Representative histological changes through GFAP staining at 1000x magnification in perilesional area of the brain. Reactiedve astrocytes are indicated by brown uptake from GFAP and have blue-colored cell nuclei. (A) Normal astrocytes: Red arrows show that not all astrocytes express detectable levels of GFAP, astrocytes have non-overlapping domains, little or no proliferation; (B) Astrogliosis: Red arrows show features of astrocytes with increased GFAP + cells accompanied by hypertrophy, astrocyte proliferation, and loss of individual domains; and (C) Glial scar: Yellow arrows indicate the appearance of glial scar with more extensive upregulation of GFAP, dense, narrow, and well-defined hypertrophic astrocyte proliferation in the perilesional area

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BMC Neurology

ISSN: 1471-2377

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