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Table 1 Demographic and clinical characteristics and laboratory test results of patients with different cognitive disorders

From: Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer’s disease and Lewy body dementia

 

All patients (n = 178)

AD patients (n = 137)

DLB LBD patients (n = 41)

P value

Age (years)

63.58 ± 8.77

62.23 ± 8.68

68.07 ± 7.55

<0.001

Female sex, n (%)

103 (57.9%)

87 (63.5%)

16 (39.0%)

0.007

Course of disease (years)

3.33 ± 2.87

3.43 ± 3.04

2.99 ± 2.19

0.39

Education level (years)

SBP (mmHg)

9.60 ± 4.26

121 ± 16.13

9.65 ± 4.25

121 ± 15.72

9.44 ± 4.34

122 ± 17.65

0.77

0.84

Regular smoking, n (%)

48 (27.0%)

34 (24.8%)

14 (34.1%)

0.31

Regular alcohol consumption, n (%)

39 (21.9%)

28 (20.4%)

11 (26.8%)

0.39

Heart disease, n (%)

15 (8.4%)

15 (10.9%)

0

0.02

Stroke, n (%)

16 (9.0%)

11 (8.0%)

5 (12.2%)

0.53

Hypertension, n (%)

60 (33.7%)

45 (32.8%)

15 (36.6%)

0.71

Diabetes, n (%)

30 (16.9%)

25 (18.2%)

5 (12.2%)

0.47

Hyperlipidemia, n (%)

72 (40.4%)

57 (41.6%)

15 (36.6%)

0.59

Anxiety state, n (%)

52 (29.2%)

38 (27.7%)

13 (31.7%)

0.43

Depression state, n (%)

57 (32.0%)

42 (30.7%)

15 (36.6%)

0.56

Sleep disorder, n (%)

87 (48.9%)

64 (46.7%)

23 (56.1%)

0.37

CSFP level(mmH2O)

121 ± 33.72

122 ± 32.56

121 ± 37.76

0.88

MMSE Score

MoCA Score

CDR

14.77 ± 7.13

10.33 ± 6.21

1.92 ± 0.82

14.70 ± 7.20

10.48 ± 6.15

1.94 ± 0.82

15.00 ± 6.99

9.80 ± 6.46

1.86 ± 0.84

0.81

0.54

0.61

Qalb

6.82 ± 5.23

6.76 ± 5.67

6.85 ± 3.63

0.80

  1. AD, Alzheimer’s disease; LBD, Lewy body dementia; MMSE, Mini-Mental State Examination; CSFP, cerebrospinal fluid pressure; MoCA, Montreal Cognitive Assessment; Qalb, cerebrospinal fluid (CSF)/serum albumin ratio; SBP, systolic blood pressure (before lumbar puncture)
  2. Bold: Significant differences were found in age (p < 0.001), sex (p = 0.007), and history of heart disease (p = 0.02) between patients with AD and LBD