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Table 4 Associations between CSFP and CSF biomarkers of AD and Qalb values

From: Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer’s disease and Lewy body dementia

 

Linear regressions

B

SE

Beta

t

P value

B 95% CI

All patients

Aβ1–42 (pg/ml)

1.21

0.99

0.10

1.21

0.23

-0.77-3.17

Aβ1–40 (pg/ml)

10.55

13.77

0.06

0.76

0.44

-16.71-37.81

t-tau (pg/ml)

13.58

9.03

0.13

1.50

0.13

-4.29-31.29

p-tau181 (pg/ml)

-0.11

0.31

0.03

0.33

0.73

-0.51-0.72

Aβ1–42/Aβ1–40

-3.62

8.7 × 10-5

-0.03

-0.41

0.68

-2.1 × 10-4-1.3 × 10-4

p-tau181/Aβ1–42

2.8 × 10-4

0.001

0.02

0.26

0.79

-0.002-0.002

Qalb

-0.03

0.01

-0.21

-2.79

0.006

-0.05-0.01

AD patients

Aβ1–42 (pg/ml)

0.94

1.15

0.07

0.81

0.41

-1.35-3.23

Aβ1–40 (pg/ml)

16.93

16.53

0.10

1.02

0.31

-15.88-49.74

t-tau (pg/ml)

16.08

11.56

0.13

1.39

0.16

-6.87-39.03

p-tau181 (pg/ml)

0.06

0.40

0.01

0.16

0.86

-0.72-0.86

Aβ1–42/Aβ1–40

1.2 × 10-4

1.0 × 10-4

-0.12

-1.26

0.21

-3.2 × 10-4-7.2 × 10-5

p-tau181/Aβ1–42

2.8 × 10-4

0.001

0.02

0.21

0.83

-0.002-0.003

Qalb

-0.04

0.15

-0.24

-2.78

0.006

-0.07-0.01

LBD patients

Aβ1–42 (pg/ml)

4.22

2.01

0.46

2.09

0.04

0.02–8.42

Aβ1–40 (pg/ml)

4.55

23.65

0.04

0.19

0.84

-44.78-53.89

t-tau (pg/ml)

1.69

1.71

0.21

0.99

0.33

-1.87-5.27

p-tau181 (pg/ml)

0.12

0.18

0.15

0.69

0.49

-0.25-0.51

Aβ1–42/Aβ1–40

3.0 × 10-4

1.8 × 10-4

0.36

1.59

0.12

-9.3 × 10-5-0.001

p-tau181/Aβ1–42

2.2 × 10-4

0.001

-0.06

-0.27

0.78

-0.002-0.001

Qalb

-0.01

0.01

-0.17

-0.86

0.39

-0.05-0.02

  1. The linear regression models were analyzed after adjusting for sex, age, education level, course of disease, and MMSE score for CSF biomarkers of AD. For the Qalb, we adjusted for sex, age, education level, course of disease and vascular risk factors
  2. AD, Alzheimer’s disease; LBD, Lewy body dementia; Aβ, β-amyloid; p-tau181, phosphorylated tau181; t-tau, total tau; Qalb, cerebrospinal fluid/serum albumin value
  3. Bold: CSFP was negatively associated with Qalb values in all patients (p = 0.006) and the patients with AD (p = 0.006). And there was a linear ralationship between CSFP and the levels of Aβ1-42 in the patients with LBD (p = 0.04)