Enhanced renal clearance impacts levetiracetam concentrations in patients with traumatic brain injury with and without augmented renal clearance

Table 1 Patient characteristics

Characteristic	ARC (N = 17)	No ARC (N = 5)	P-value
Age (years)	38.3 (17.6)	50 (18.9)	0.212
Gender (N, % male)	11 (64.7%)	4 (80%)	0.52
Ethnicity (N, %)
Caucasian	11 (64.7%)	4 (80%)
Black	2 (11.8%)	0 (0%)
Hispanic	2 (11.8%)	0 (0%)
Asian	1 (5.9%)	0 (0%)
Other/unknown	1 (5.9%)	1 (20%)
Weight (kg)	76.9 (20)	84.8 (12.8)	0.42
BMI (kg/m²)	25.4 (5)	28.8 (5.4)	0.211
Admission GCS	4 (3–10)	5 (3–6)	0.829
Admission Scr (mg/dl)	0.82 (0.24)	0.96 (0.25)	0.287
SOFA score	7 (2.8)	8 (2.9)	0.508
ARCTIC score	6.8 (1.4)	6.2 (1.4)	0.025
ICU length of stay (days)	15 (4–91)	8 (3–18)	0.28
Hospital length of stay (days)	15 (4-128)	9 (3–24)	0.28
In-hospital mortality	2 (11.8%)	3 (60%)	0.055
Measured creatinine clearance (ml/min/1.73 m²)	190.5 (59)	122 (36)	< 0.001

Data is represented as mean (standard deviation) or median (range) unless otherwise specified
BMI body mass index, GCS Glasgow Coma score, Scr serum creatinine, SOFA sequential organ failure assessment, ARTIC augmented renal clearance in trauma intensive care, ICU intensive care unit

ISSN: 1471-2377