Table 2 Comparisons of baseline characteristics among the MHR tertiles

Number

1,048

1,049

1,047

Age, y [IQR]

56 [51–62]

56 [50–63]

56 [49–64]

0.898

0.926

Sex, male, n (%)

346 (33.0)

555 (52.9)

795 (75.9)

 < 0.001

 < 0.001

Body mass index

23.19 [21.30–25.08]

24.02 [22.32–25.95]

24.69 [22.94–26.64]

 < 0.001

 < 0.001

Hypertension, n (%)

218 (20.8)

268 (25.5)

305 (29.1)

 < 0.001

 < 0.001

Diabetes, n (%)

108 (10.3)

137 (13.1)

217 (20.7)

 < 0.001

 < 0.001

Hyperlipidemia, n (%)

166 (15.8)

168 (16.0)

146 (13.9)

0.344

0.228

Ischemic heart disease, n (%)

27 (2.6)

38 (3.6)

43 (4.1)

0.145

0.054

Current smoking, n (%)

74 (7.1)

149 (14.2)

342 (32.7)

 < 0.001

 < 0.001

Systolic blood pressure, mmHg [IQR]

123 [113–134]

126 [116–136]

127 [117–138]

 < 0.001

 < 0.001

Diastolic blood pressure, mmHg [IQR]

74 [67–82]

75 [69–83]

76 [70–85]

 < 0.001

 < 0.001

Hemoglobin A1c, % [IQR]

5.7 [5.4–5.9]

5.7 [5.5–6.0]

5.8 [5.5–6.2]

 < 0.001

 < 0.001

Fasting glucose, mg/dL [IQR]

5.00 [4.67–5.50]

5.06 [4.67–5.61]

5.17 [4.78–5.83]

 < 0.001

 < 0.001

Total cholesterol, mmol/L [IQR]

5.22 [4.60–5.82]

5.12 [4.50–5.77]

5.02 [4.40–5.66]

 < 0.001

 < 0.001

LDL cholesterol, mmol/L [IQR]

3.15 [2.53–3.72]

3.31 [2.74–3.93]

3.23 [2.61–3.87]

 < 0.001

0.018

Triglyceride, mmol/L [IQR]

0.89 [0.70–1.20]

1.12 [0.86–1.56]

1.48 [1.07–2.12]

 < 0.001

 < 0.001

WBC counts, × 10³/μL [IQR]

4.46 [3.80–5.24]

5.29 [4.53–6.12]

6.43 [5.50–7.72]

 < 0.001

 < 0.001

Neutrophil counts, × 10³/μL [IQR]

2.37 [1.89–2.92]

2.83 [2.23–3.47]

3.53 [2.85–4.44]

 < 0.001

 < 0.001

Lymphocyte counts, × 10³/μL [IQR]

1.65 [1.36–1.94]

1.87 [1.56–2.17]

2.09 [1.76–2.50]

 < 0.001

 < 0.001

High-sensitivity CRP, mg/dL [IQR]

0.01 [0.01–0.07]

0.04 [0.01–0.13]

0.12 [0.01–0.24]

 < 0.001

 < 0.001

NLR, [IQR]

1.43 [1.09–1.92]

1.49 [1.17–1.96]

1.68 [1.28–2.18]

 < 0.001

 < 0.001

WMH volume, mL [IQR]

0.93 [0.19–2.42]

1.07 [0.20–2.60]

1.20 [0.20–2.90]

0.019

0.005

Lacunes, n (%)

62 (5.9)

68 (6.5)

100 (9.6)

0.003

0.001

Cerebral microbleeds, n (%)

35 (3.3)

37 (3.5)

57 (5.4)

0.027

0.015