Table 3 Univariate and multivariable analyses to evaluate the association between possible predictors and white matter hyperintensity volume
| Â | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
B (95% CI) | P-value | B (95% CI) | P-value | |
Age | 0.053 (0.050 to 0.057) |  < 0.001 | 0.050 (0.046 to 0.054) |  < 0.001 |
Sex, male | 0.025 (-0.054 to 0.103) | 0.538 | … | … |
BMI | -0.001 (-0.013 to 0.012) | 0.919 | … | … |
Hypertension | 0.471 (0.382 to 0.559) |  < 0.001 | 0.163 (0.077 to 0.249) |  < 0.001 |
Diabetes | 0.413 (0.304 to 0.523) |  < 0.001 | 0.143 (0.002 to 0.284) | 0.047 |
Hyperlipidemia | 0.075 (-0.033 to 0.184) | 0.174 | … | … |
IHD | 0.113 (-0.101 to 0.327) | 0.301 | … | … |
Current smoking | -0.194 (-0.296 to -0.093) |  < 0.001 | 0.029 (-0.067 to 0.126) | 0.554 |
Use of anti-PLT | 0.291 (0.162 to 0.420) |  < 0.001 | -0.060 (-0.180 to 0.060) | 0.325 |
Systolic BP | 0.011 (0.009 to 0.014) |  < 0.001 | 0.006 (0.002 to 0.010) | 0.003 |
Diastolic BP | 0.008 (0.004 to 0.011) |  < 0.001 | -0.001 (-0.007 to 0.005) | 0.732 |
HbA1*c | 1.200 (0.860 to 1.541) |  < 0.001 | -0.346 (-0.846 to 0.154) | 0.175 |
Fasting glucosea | 0.670 (0.470 to 0.871) |  < 0.001 | 0.075 (-0.193 to 0.343) | 0.582 |
Total cholesterol | -0.038 (-0.080 to 0.004) | 0.076 | … | … |
LDL cholesterol | -0.049 (-0.097 to -0.002) | 0.041 | … | … |
HDL cholesterol | -0.037 (-0.144 to 0.071) | 0.507 | … | … |
Triglyceridea | 0.056 (-0.022 to 0.134) | 0.162 | … | … |
WBC counts | 0.046 (0.023 to 0.069) |  < 0.001 | … | … |
Neutrophil counts | 0.072 (0.042 to 0.102) |  < 0.001 | … | … |
Lymphocyte counts | -0.018 (-0.089 to 0.052) | 0.609 | … | … |
Monocyte counts | 0.556 (0.275 to 0.836) |  < 0.001 | … | … |
hs-CRPa | 0.016 (-0.010 to 0.042) | 0.235 | … | … |
NLRa | 0.244 (0.152 to 0.337) |  < 0.001 | … | … |
MHRa | 0.138 (0.059 to 0.217) | 0.001 | 0.099 (0.025 to 0.174) | 0.009 |