Table 1 Baseline characteristics by APOE4
Non-APOE4 carrier | APOE4 carrier | P-value* | |
|---|---|---|---|
Age (years) | 56.88 ± 8.02 | 56.67 ± 8.04 | < 0.0001 |
Sex | 1.00 | ||
Women | 120,856 (54.8) | 60,428 (54.8) | |
Men | 99,852 (45.2) | 49,926 (45.2) | |
Education | 0.59 | ||
College/university degree | 70,807 (32.1) | 36,464 (33.0) | |
Upper secondary | 25,104 (11.4) | 12,691 (11.5) | |
Final stage of secondary education | 48,144 (21.8) | 23,993 (21.7) | |
Lower secondary | 11,908 (5.4) | 5921 (5.4) | |
First stage of secondary education | 14,379 (6.5) | 7025 (6.4) | |
Vocational qualifications | 11,425 (5.2) | 5650 (5.1) | |
None of above | 38,941 (17.6) | 18,610 (16.9) | |
Household income (pounds) | < 0.0001 | ||
< 18,000 | 49,911 (22.6) | 23,979 (21.7) | |
18,000–30,999 | 60,963 (27.6) | 30,298 (27.5) | |
31,000–51,999 | 58,030 (26.3) | 29,470 (26.7) | |
52,000–100,000 | 41,411 (18.8) | 21,344 (19.3) | |
> 100,000 | 10,393 (4.7) | 5263 (4.8) | |
Townsend index | -1.44 ± 3.00 | -1.52 ± 2.95 | < 0.0001 |
Alcohol consumption | 0.0003 | ||
Never | 7314 (3.3) | 3474 (3.1) | |
Previous | 7873 (3.6) | 3745 (3.4) | |
Current | 205,521 (93.1) | 103,135 (93.5) | |
Smoking | < 0.0001 | ||
Never | 119,090 (54.0) | 60,292 (54.6) | |
Former | 78,030 (35.4) | 39,831 (36.1) | |
Current | 23,588 (10.7) | 10,231 (9.3) | |
Physical activity (MET-minutes/week) | 2659 ± 2441 | 2683 ± 2448 | 0.0074 |
Diet scorea | 3.87 ± 1.43 | 3.92 ± 1.43 | < 0.0001 |
Sleep duration (hours) | 7.17 ± 1.10 | 7.16 ± 1.08 | 0.0153 |
BMI (kg/m2) | 27.45 ± 4.74 | 27.26 ± 4.67 | < 0.0001 |
Overall health rating | < 0.0001 | ||
Excellent | 36,703 (16.6) | 18,687 (16.9) | |
Good | 128,531 (58.2) | 65,068 (59.0) | |
Fair | 45,994 (20.8) | 22,101 (20.0) | |
Poor | 9480 (4.3) | 4498 (4.1) | |
Long-standing illness, disability or infirmity | < 0.0001 | ||
No | 148,184 (67.1) | 75,033 (68.0) | |
Yes | 72,524 (32.9) | 35,321 (32.0) | |
Multimorbidity risk score | 0.27 ± 0.29 | 0.26 ± 0.29 | 0.0835 |
Trunk fat percentage | 31.23 ± 8.00 | 30.96 ± 7.99 | < 0.0001 |
Whole body fat percentage | 31.51 ± 8.52 | 31.25 ± 8.50 | < 0.0001 |
HbA1c (mmol/mol) | 14.19 ± 1.22 | 14.17 ± 1.22 | 0.0001 |
Triglycerides (mmol/L) | 1.74 ± 0.98 | 1.79 ± 1.04 | < 0.0001 |
Total cholesterol (mmol/L) | 5.67 ± 1.13 | 5.86 ± 1.17 | < 0.0001 |
HDL-C (mmol/L) | 1.46 ± 0.36 | 1.44 ± 0.35 | < 0.0001 |
LDL-C (mmol/L) | 3.53 ± 0.84 | 3.69 ± 0.87 | < 0.0001 |