Table 1 Demographic and clinical characteristics of physician-diagnosed migraine patients, physician-diagnosed migraine patients treated for migraine within the past 24 months, and overall population covered by the electronic medical records database from May 2021 to April 2022

Gender, n (%)

Female

47,585 (77.7)

25,177 (81.3)^***

577,197 (51.9)

77,750 (77.7)

Male

13,618 (22.3)

5,804 (18.7)^***

534,937 (48.1)

22,251 (22.3)

Age, n (%)

Female

< 12 years old

66 (0.1)

42 (0.2)^***

54,833 (9.5)

108 (0.1)

12–18 years old

778 (1.6)

481 (1.9)^***

38,672 (6.7)

1,271 (1.6)

19–29 years old

4,463 (9.4)

2,314 (9.2)^***

68,109 (11.8)

7,293 (9.4)

30–39 years old

7,826 (16.4)

4,031 (16)^***

79,653 (13.8)

12,788 (16.4)

40–49 years old

11,630 (24.4)

6,636 (26.4)^***

94,083 (16.3)

19,002 (24.4)

50–59 years old

10,715 (22.5)

6,062 (24.1)^***

84,847 (14.7)

17,507 (22.5)

≥ 60 years old

12,104 (25.4)

5,609 (22.3)^***

156,997 (27.2)

19,777 (25.4)

Male

< 12 years old

58 (0.4)

39 (0.7)

58,307 (10.9)

96 (0.4)

12–18 years old

486 (3.6)

247 (4.3)

40,120 (7.5)

794 (3.6)

19–29 years old

1,642 (12.1)

585 (10.1)

62,587 (11.7)

2,684 (12.1)

30–39 years old

2,171 (15.9)

871 (15)

71,146 (13.3)

3,548 (15.9)

40–49 years old

3,234 (23.8)

1,462 (25.2)

92,009 (17.2)

5,285 (23.8)

50–59 years old

2,863 (21)

1,340 (23.1)

81,310 (15.2)

4,678 (21)

≥ 60 years old

3,160 (23.2)

1,257 (21.7)

129,455 (24.2)

5,163 (23.2)

Comorbidities, n (%)

Cardiovascular

14,995 (24.5)^***

7,250 (23.4)^***

222,427 (20)

21,673 (21.7)

Acute pulmonary heart diseases

184 (0.3)

93 (0.3)

3,336 (0.3)

339 (0.3)

Chronic cardiac rheumatic disease

184 (0.3)

94 (0.3)

3,558 (0.3)

353 (0.4)

Arterial hypertension

11,629 (19)^***

5,670 (18.3)^***

173,492 (15.6)

17,025 (17)

Ischemic disease (AMI/AP)

1,408 (2.3)

527 (1.7)^***

28,915 (2.6)

2,197 (2.2)

Other CV diseases

3,856 (6.3)^***

1,673 (5,0.4)

62,279 (5.6)

5,678 (5.7)

Peripheral CV Disease

1,346 (2.2)^***

651 (2.1)^***

18,906 (1.7)

1,745 (1.7)

Stroke

1,653 (2.7)^***

806 (2.6)^***

23,021 (2.1)

2,063 (2.1)

Digestive

15,546 (25.4)^***

8,582 (27.7)^***

164,596 (14.8)

16,783 (16.8)

Gastrointestinal diseases 1^b

11,323 (18.5)^***

6,506 (21)^***

108,989 (9.8)

12,191 (12.2)

Gastrointestinal diseases 2^c

5,692 (9.3)^***

2,881 (9.3)^***

66,727 (6)

5,943 (5.9)

Metabolic

23,625 (38.6)^***

11,866 (38.3)^***

311,397 (28)

33,079 (33.1)

Dyslipidaemia

15,668 (25.6)^***

7,807 (25.2)^***

212,417 (19.1)

21,787 (21.8)

Obesity

7,773 (12.7) ^***

3,873 (12.5)^***

96,755 (8.7)

10,372 (10.4)

Diabetes (Type 1 / Type 2)

4,407 (7.2)^***

1,983 (6.4)^***

84,522 (7.6)

7,690 (7.7)

Hypothyroidism

4,774 (7.8)^***

2,510 (8.1)^***

44,485 (4)

6,342 (6.3)

Neurologic

796 (1.3)^***

434 (1.4)^***

10,009 (0.9)

923 (0.9)

Epilepsy

796 (1.3)^***

434 (1.4)^***

10,009 (0.9)

923 (0.9)

Neuropsychiatric

21,421 (35)^***

12,703 (41)^***

180,165 (16.2)

21,881 (21.9)

Anxiety, Dissociative and Somatoform Disorders

17,198 (28.1)^***

9,666 (31.2)^***

144,537 (13)

18,229 (18.2)

Bipolar Disorder

734 (1.2)^***

434 (1.4)^***

6,672 (0.6)

800 (0.8)

Depression

3,489 (5.7)^***

2,014 (6.5)^***

30,027 (2.7)

3,701 (3.7)

Drug abuse

122 (0.2)^***

62 (0.2)^***

1,111 (0.1)

97 (0.1)

Drug dependency

190 (0.3)^***

93 (0.3)^***

2,223 (0.2)

181 (0.2)

Other syndromes

3,795 (6.2)^***

3,563 (11.5)^***

15,569 (1.4)

2,119 (2.1)

Stress syndromes

61 (0.1)^*

31 (0.1)

1,118 (0.1)

68 (0.1)

ADHD

245 (0.4)^***

155 (0.5)^***

6,672 (0.6)

213 (0.2)

Pain

31,092 (50.8)^***

16,482 (53.2)^***

324,743 (29.2)

37,466 (37.5)

Chronic Pain, Fibromyalgia, Generalised Pain

5,202 (8.5)^***

2,912 (9.4)^***

50,046 (4.5)

5,794 (5.8)

Dorsopathies

23,441 (38.3)^***

12,672 (40.9)^***

227,987 (20.5)

26,836 (26.8)

Chronic Fatigue Syndrome

6 (0)

3 (0)

222 (0)

3 (0)

Disorders of the peripheral nervous system

7,222 (11.8)^***

3,904 (12.6)^***

58,942 (5.3)

7,195 (7.2)

Osteoarthrosis and related disorders

7,528 (12.3)^***

3,532 (11.4)^***

87,858 (7.9)

10,101 (10.1)

Temporomandibular joint disorders

612 (1)^***

341 (1.1)^***

4,448 (0.4)

539 (0.5)

Respiratory

7,228 (11.8)^***

3,718 (12)^***

83,410 (7.5)

7,937 (7.9)

Asthma / COPD

6,365 (10.4)^***

3,315 (10.7)^***

77,849 (7)

7,265 (7.3)

Sinusitis

979 (1.6)^***

527 (1.7)^***

6,672 (0.6)

797 (0.8)

Rheumatologic

490 (0.8)^*

248 (0.8)

5,560 (0.5)

695 (0.7)

Arthritis

490 (0.8)^*

248 (0.8)

5,560 (0.5)

695 (0.7)

Sleep

6,916 (11.3)^***

3,966 (12.8)^***

67,840 (6.1)

7,704 (7.7)