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  1. Content type: Research article

    Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease characterized by substantial clinical and genetic heterogeneity. Thus far, only a few TARDBP-ALS families have been reported in China, and...

    Authors: Guo-rong Xu, Wei Hu, Ling-Ling Zhan, Chong Wang, Liu-Qing Xu, Min-Ting Lin, Wan-Jin Chen, Ning Wang and Qi-Jie Zhang

    Citation: BMC Neurology 2018 18:35

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  2. Content type: Research article

    Wilson disease is a rare genetic disorder in which impaired copper excretion results in toxic copper levels and tissue damage. Manifestations are primarily hepatic and/or neuropsychiatric, with a variety of ne...

    Authors: Anna Członkowska, Tomasz Litwin, Karolina Dzieżyc, Michal Karliński, Johan Bring and Carl Bjartmar

    Citation: BMC Neurology 2018 18:34

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  3. Content type: Research article

    Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrh...

    Authors: Martin A. Chacon-Portillo, Rafael H. Llinas and Elisabeth B. Marsh

    Citation: BMC Neurology 2018 18:33

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  4. Content type: Research article

    There have been found apoptotic changes in brain tissue samples from humans after cerebral ischemia. Caspase-cleaved cytokeratin (CCCK)-18 could appears in blood during apoptosis. High circulating levels of CC...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín

    Citation: BMC Neurology 2018 18:32

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  5. Content type: Study protocol

    Intracerebral hemorrhage is a devastating disease with no specific treatment modalities. A significant proportion of patients with intracerebral hemorrhage are transferred to large stroke treatment centers, su...

    Authors: Farhaan S. Vahidy, Ellie G. Meyer, Arvind B. Bambhroliya, Jennifer R. Meeks, Charles E. Begley, Tzu-Ching Wu, Jon E. Tyson, Charles C. Miller, Ritvij Bowry, Wamda O. Ahmed, Gretchel A. Gealogo, Louise D. McCullough, Steven Warach and Sean I. Savitz

    Citation: BMC Neurology 2018 18:31

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  6. Content type: Research article

    Constipation is one of the most frequent non-motor symptoms (NMS) in Parkinson’s disease (PD) and the prevalence of constipation in PD patients varies among different studies. We designed this study to survey ...

    Authors: Jing Gan, Ying Wan, Junjie Shi, Mingzhu Zhou, Zhiyin Lou and Zhenguo Liu

    Citation: BMC Neurology 2018 18:29

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  7. Content type: Research article

    A significant proportion of patients with mild ischemic stroke become disabled despite receiving intravenous thrombolytic therapy. The purpose of this study was to assess the clinical and radiological factors ...

    Authors: Dae-Hyun Kim, Deok-Soo Lee, Hyun-Wook Nah and Jae-Kwan Cha

    Citation: BMC Neurology 2018 18:30

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  9. Content type: Research article

    Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature o...

    Authors: Raed Alroughani and Alexey Boyko

    Citation: BMC Neurology 2018 18:27

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  10. Content type: Research article

    Prognostic models have been increasingly developed to predict complete recovery in ischemic stroke. However, questions arise about the performance characteristics of these models. The aim of this study was to ...

    Authors: Nampet Jampathong, Malinee Laopaiboon, Siwanon Rattanakanokchai and Porjai Pattanittum

    Citation: BMC Neurology 2018 18:26

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  11. Content type: Research article

    The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.

    Authors: Chahra Chbili, Anis Hassine, Neila Fathallah, Manel Nouira, Salma Naija, Sofiene Ben Ammou and Saad Saguem

    Citation: BMC Neurology 2018 18:24

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  12. Content type: Research article

    Spiral drawing on papers is a common tremor evaluation tool for diagnosing patients with essential tremor (ET) or Parkinson’s disease (PD). No standard drawing methods and parameters that use graphic tablets a...

    Authors: Po-Chieh Lin, Kai-Hsiang Chen, Bing-Shiang Yang and Yu-Jung Chen

    Citation: BMC Neurology 2018 18:25

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  13. Content type: Research article

    Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary a...

    Authors: Vera Spatenkova, Ondrej Bradac, Daniela Fackova, Zdenka Bohunova and Petr Suchomel

    Citation: BMC Neurology 2018 18:23

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  14. Content type: Research article

    The objective of this study was to evaluate and identify the risk factors for developing a new or enlarged intracranial hemorrhage (ICH) after the placement of an external ventricular drain.

    Authors: A. Shaun Rowe, Derrick R. Rinehart, Stephanie Lezatte and J. Russell Langdon

    Citation: BMC Neurology 2018 18:22

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  15. Content type: Research article

    Chronic kidney disease increases stroke incidence and severity but the mechanisms behind this cerebro-renal interaction are mostly unexplored. Since both vascular beds share similar features, microvascular dys...

    Authors: Pedro Castro, Elsa Azevedo, Isabel Rocha, Farzaneh Sorond and Jorge M. Serrador

    Citation: BMC Neurology 2018 18:21

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  16. Content type: Research article

    Parkinson’s disease is a heterogeneous disorder where genetic factors may underlie clinical variability. Rapid eye movement sleep behavior disorder (RBD) is a parasomnia strongly linked to synucleinopathies, i...

    Authors: Kari Anne Bjørnarå, Lasse Pihlstrøm, Espen Dietrichs and Mathias Toft

    Citation: BMC Neurology 2018 18:20

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  17. Content type: Research article

    Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predic...

    Authors: David Morley, Sarah Dummett, Laura Kelly, Ray Fitzpatrick and Crispin Jenkinson

    Citation: BMC Neurology 2018 18:19

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  18. Content type: Research article

    Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with t...

    Authors: Xiao-han Jiang, Si-bo Wang, Qian Tian, Chi Zhong, Guan-ling Zhang, Ya-jie Li, Pan Lin, Yong You, Rong Guo, Ying-hua Cui and Ying-qi Xing

    Citation: BMC Neurology 2018 18:18

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  19. Content type: Research article

    Neuromuscular electrical stimulation (NMES) is commonly used in skeletal muscles in people with spinal cord injury (SCI) with the aim of increasing muscle recruitment and thus muscle force production. NMES has...

    Authors: Vanesa Bochkezanian, Robert U. Newton, Gabriel S. Trajano, Amilton Vieira, Timothy S. Pulverenti and Anthony J. Blazevich

    Citation: BMC Neurology 2018 18:17

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  20. Content type: Research article

    Clinical scales to detect large vessel occlusion (LVO) may help to determine the optimal transport destination for patients with suspected acute ischemic stroke (AIS). The clinical benefit associated with impr...

    Authors: Ludwig Schlemm and Eckhard Schlemm

    Citation: BMC Neurology 2018 18:16

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  21. Content type: Research article

    Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran.

    Authors: Sharareh Eskandarieh, Narges Sistany Allahabadi, Malihe Sadeghi and Mohammad Ali Sahraian

    Citation: BMC Neurology 2018 18:15

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  22. Content type: Research article

    Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS)....

    Authors: Tilman Hottenrott, Rick Dersch, Benjamin Berger, Dominique Endres, Daniela Huzly, Jens Thiel, Sebastian Rauer, Oliver Stich, Ulrich Salzer and Nils Venhoff

    Citation: BMC Neurology 2018 18:14

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  23. Content type: Study protocol

    The level of physical activity undertaken by stroke survivors living in the community is generally low. The main objectives of the IMPACT trial are to determine, in individuals undergoing rehabilitation after str...

    Authors: Sandra G. Brauer, Suzanne S. Kuys, Jennifer D. Paratz and Louise Ada

    Citation: BMC Neurology 2018 18:13

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  24. Content type: Research article

    Data on the association between socioeconomic status and post-stroke functional outcome in developing countries is lacking. We aimed to evaluate the association in stroke survivors in deprived rural Southern C...

    Authors: Fubing Ouyang, Ying Wang, Weixian Huang, Yicong Chen, Yuhui Zhao, Ge Dang, Chunbo Zhang, Yang Lin and Jinsheng Zeng

    Citation: BMC Neurology 2018 18:12

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