Articles

Venous sinus stenting improves cerebral autoregulation in a patient with venous sinus stenosis: a case report

Venous sinus stenosis (VSS) is a type of cerebral venous vascular disease. Cerebral autoregulation is an indicator of cerebral arterial function. The cerebral circulatory system is composed of the venous syste...

Authors: Meiyan Jia, Zhen-Ni Guo, Hang Jin, Xiuli Yan, Mingchao Shi, Xin Sun, Hongyin Ma, Shan Lv and Yi Yang

Comparing healthcare cost associated with the use of enzyme-inducing and non-enzyme active antiepileptic drugs in elderly patients with epilepsy in the UK: a long-term retrospective, matched cohort study

In elderly patients (≥65 years of age) with epilepsy who take medications for comorbid conditions, some antiepileptic drugs (AEDs) may alter the metabolism of other treatments and increase the risk of adverse ...

Authors: Simon Borghs, Laura Byram, Jane Chan, Peter Dedeken, John Logan, Victor Kiri, Matthias Noack-Rink, Philip N. Patsalos and Solène Thieffry

Early diagnostic value of serum procalcitonin levels for catheter-related blood stream infection in first-ever acute ischemic stroke patients

The traditional approaches for diagnosing catheter-related bloodstream infection(CRBSI) is time consuming, which could not meet the clinical requirement. Our aim was to investigate the value of serum procalcit...

Authors: Yicheng Xu, Ruiwei Chen, Wei Qin, Peifu Wang, Peiyao Li, Wenli Hu and Jichen Du

Prevalence of stroke and stroke related risk factors: a population based cross sectional survey in southwestern China

Stroke and its risk factors epidemiological survey can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence ...

Authors: Xingyang Yi, Hua Luo, Ju Zhou, Ming Yu, Xiaorong Chen, Lili Tan, Wei Wei and Jie Li

Experienced pain after stroke: a cross-sectional 5-year follow-up study

Stroke is one of the most common cause of disability worldwide. Pain is common in both stroke survivors and in the general population. Consequences of post-stroke pain (PSP) include reduced quality of life and...

Authors: Emma Westerlind, Ramanjit Singh, Hanna C. Persson and Katharina S. Sunnerhagen

Correlation between multiple cerebral aneurysms and a rare type of segmental duplication of the middle cerebral artery

Connection between the duplication of the middle cerebral artery (DMCA) and the presence of multiple aneurysms has been described in a small number of cases.

Authors: Nebojša N. Stojanović, Aleksandar Kostić, Radisav Mitić and Luka Berilažić

Chinese families with autosomal recessive hereditary spastic paraplegia caused by mutations in SPG11

Spastic paraplegia type 11 (SPG11) mutations are the most frequent cause of autosomal recessive hereditary spastic paraplegia (ARHSP). We are aiming to identify the causative mutations in SPG11 among families ref...

Authors: Xueping Chen, Jiao Liu, Qian-Qian Wei, Ru Wei Ou, Bei Cao, Xiaoqin Yuan, Yanbing Hou, Lingyu Zhang and Huifang Shang

Clinical characteristics and prognostic analysis of anti-gamma-aminobutyric acid-B (GABA-B) receptor encephalitis in Northeast China

To investigate the clinical characteristics and prognosis of anti-gamma-aminobutyric acid-B (GABA-B) receptor encephalitis.

Authors: Xinyue Zhang, Yue Lang, Lichao Sun, Weiguanliu Zhang, Weihong Lin and Li Cui

Neuromyelitis optica spectrum disorder with massive basal ganglia involvement: a case report

Occurrence of basal ganglia involvement in neuromyelitis optica spectrum disorders (NMOSD) has rarely been reported and none documented pathologically.

Authors: Shinji Ohara, Taka-aki Miyahira, Kenya Oguchi, Yo-ichi Takei, Fumihiro Yanagimura, Izumi Kawachi, Kiyomitsu Oyanagi and Akiyoshi Kakita

Functional MRI study in a case of Charles Bonnet syndrome related to LHON

Charles Bonnet syndrome is characterized by simple or complex visual hallucinations (VH) due to damage along the visual pathways. We report a functional MRI study of brain correlates of VH in the context of a ...

Authors: V. Vacchiano, C. Tonon, M. Mitolo, S. Evangelisti, M. Carbonelli, R. Liguori, R. Lodi, V. Carelli and C. La Morgia

Ischemic stroke in Morocco: a systematic review

The aim of this systematic review is to determine the epidemiological and etiological profiles, the influential factors of the prehospital delay, thrombolysis management, the acute and 3-month mortality rate a...

Authors: Ahmed Kharbach, Majdouline Obtel, Laila Lahlou, Jehanne Aasfara, Nour Mekaoui and Rachid Razine

A rare but treatable cause of recurrent chest pain - Ictal chest pain

Chest pain as the primary manifestation of epilepsy is extremely rare and has only been reported once to date.

Authors: Ching Soong Khoo, Dongah Lee, Kang Min Park, Byung In Lee and Sung Eun Kim

A nomogram for predicting the in-hospital mortality after large hemispheric infarction

Large hemispheric infarction (LHI) is a severe form of stroke with high mortality and disability rates. The purpose of this study was to explore predictive indicators of the in-hospital mortality of LHI patien...

Authors: Wenzhe Sun, Guo Li, Ziqiang Liu, Jinfeng Miao, Zhaoxia Yang, Qiao Zhou, Run Liu, Suiqiang Zhu and Zhou Zhu

The association between high-sensitivity C-reactive protein at admission and progressive motor deficits in patients with penetrating artery infarctions

A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at ad...

Authors: Pengyu Gong, Yukai Liu, Ting Huang, Wenxiu Chen, Teng Jiang, Yachi Gong, Min Lu, Meng Wang, Yingdong Zhang, Xiaohao Zhang, Qiwen Deng and Junshan Zhou

Novel variants in a patient with late-onset hyperprolinemia type II: diagnostic key for status epilepticus and lactic acidosis

Hyperprolinemia type 2 (HPII) is a rare autosomal recessive disorder of the proline metabolism, that affects the ALDH4A1 gene. So far only four different pathogenic mutations are known. The manifestation is mostl...

Authors: Jeremias Motte, Anna Lena Fisse, Thomas Grüter, Ruth Schneider, Thomas Breuer, Thomas Lücke, Stefan Krueger, Huu Phuc Nguyen, Ralf Gold, Ilya Ayzenberg and Gisa Ellrichmann

Action observation training for rehabilitation in brain injuries: a systematic review and meta-analysis

To systematically review and analyse the effects of Action Observation Training on adults and children with brain damage.

Authors: Bianca Buchignani, Elena Beani, Valerie Pomeroy, Oriana Iacono, Elisa Sicola, Silvia Perazza, Eleonora Bieber, Hilde Feys, Katrijn Klingels, Giovanni Cioni and Giuseppina Sgandurra

Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease

Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what d...

Authors: Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van der Grond, Clare E. Mackay and Serge A. R. B. Rombouts

The frequency and impact of admission hyperglycemia on short term outcome of acute stroke patients admitted to Tikur Anbessa Specialized hospital, Addis Ababa, Ethiopia: a cross-sectional study

Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outc...

Authors: Yared Zenebe Zewde, Abenet Tafesse Mengesha, Yeweynhareg Feleke Gebreyes and Halvor Naess

Microvascular decompression for the treatment of neurogenic hypertension with trigeminal neuralgia

To evaluate the efficacy of microvascular decompression (MVD) in reducing hypertension (HTN) in hypertensive patients with trigeminal neuralgia (TN).

Authors: Wenchao Lu, Hui Wang, Zhongnan Yan, Yuangang Wang and Hongmin Che

Cognitive mediated eye movements during the SDMT reveal the challenges with processing speed faced by people with MS

The Symbol Digit Modalities Test (SDMT) is regarded as the cognitive test of choice for people with MS (pwMS). While deficits are linked to impaired processing speed, the mechanisms by which they arise are unc...

Authors: Bennis Pavisian, Viral P. Patel and Anthony Feinstein

Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. T...

Authors: Danyal Imani, Bahman Razi, Morteza Motallebnezhad and Ramazan Rezaei

Discrepancy in the perception of symptoms of cognitive decline between older adults and their family members: results of the Toyama dementia survey

Early consultation is important to delay the onset of dementia. The present study aimed to explore the reasons for delaying a consultation of dementia while focusing on the differences in the perception of cog...

Authors: Nobue Nakahori, Michikazu Sekine, Masaaki Yamada, Takashi Tatsuse, Hideki Kido and Michio Suzuki

Clinical value of vestibular-evoked myogenic potential tests in patients with sudden sensorineural hearing loss

This study aims to investigate the clinical value of two kinds of vestibular-evoked myogenic potentials in patients with sudden sensorineural hearing loss (SSNHL).

Authors: Yuan Wang, Shun-Tong Gu, Xiao-Lin Bao and Jia-Liang Guo

Correction to: Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic

Following publication of the original article [1], the authors reported a mistake regarding the year found in the paragraph of the Background section.

Authors: Brandon Brown, Jamie L. Weiss, Scott Kolodny, Xiangyi Meng, Ian M. Williams and John A. Osborne

Understanding side effects of therapy for myasthenia gravis and their impact on daily life

Myasthenia gravis is a chronic, autoimmune, neuromuscular junction disorder characterized by skeletal muscle weakness. Current therapies for myasthenia gravis are associated with significant side effects. The ...

Authors: Elizabeth Dansie Bacci, Karin S. Coyne, Jiat-Ling Poon, Linda Harris and Audra N. Boscoe

Chinese version of narcolepsy severity scale: a validation study

The narcolepsy severity scale (NSS) was developed to measure the severity and consequences of symptoms in patients with narcolepsy. The scale has been validated in France, though no other studies have further ...

Authors: Hui Ouyang, Fang Han, Qiwen Zheng and Jun Zhang

The eagle jugular syndrome

The elongation of the styloid process is historically associated with two variants of the Eagle syndrome. The classic one, mainly characterized by pain and dysphagia, and the carotid variant characterized by p...

Authors: Paolo Zamboni, Alba Scerrati, Erica Menegatti, Roberto Galeotti, Marcello Lapparelli, Luca Traina, Mirko Tessari, Andrea Ciorba, Pasquale De Bonis and Stefano Pelucchi

Analysis of factors influencing hospital-acquired infection in postoperative patients with intracranial aneurysm

Hospital-acquired infection (HAI) is a serious complication of neurosurgery. In recent years, the medical body has paid increasing attention to this issue.

Authors: Jun Wang, Yuanyuan Ji, Lidan Jiang, Xia Zhao, Shaochen Guan, Piao Yang, Jie Yu, Yunyun Liu and Hongqi Zhang

Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis

Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifest...

Authors: Yue Zhao, Jun-Ying He, Yue-Li Zou, Xiao-Su Guo, Jun-Zhao Cui, Li Guo and Hui Bu

Late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD): case reports and epidemiology of ETFDH gene mutations

Multiple acyl-CoA dehydrogenase deficiency (MADD) is a riboflavin-responsive lipid-storage myopathy caused by mutations in the EFTA, EFTB or ETFDH genes. We report a Chinese family of Southern Min origin with ...

Authors: Wei Chen, Youqiao Zhang, Yifeng Ni, Shaoyu Cai, Xin Zheng, Frank L. Mastaglia and Jingshan Wu

Free thyroxine level is associated with both relapse rate and poor neurofunction in first-attack Neuromyelitis Optica Spectrum Disorder (NMOSD) patients

To investigate whether the serum free thyroxine (FT4) level is a prognostic factor for the first-attack neuromyelitis optica spectrum disorders (NMOSD).

Authors: Qianyi He, Lifeng Li, Yanfei Li, Yanhui Lu, Kaimin Wu, Ruiyi Zhang, Junfang Teng, Jie Zhao and Yanjie Jia

Clinical, neuroimaging, and nerve conduction characteristics of spontaneous Conus Medullaris infarction

Spontaneous conus medullaris infarction is a rare disease. We describe two patients with spontaneous conus medullaris infarction presenting as acute cauda equina syndrome and their unique electromyography (EMG...

Authors: Yi-Ching Weng, Shy-Chyi Chin, Yah-Yuan Wu and Hung-Chou Kuo

Retraction Note: Risk factors, clinical presentations and predictors of stroke among adult patients admitted to stroke unit of Jimma university medical center, south west Ethiopia: prospective observational study

The Editor and Publisher have retracted this article [1]. This article was published as the result of a technical error which resulted in two versions [1, 2] of the same article being published. [2] is the fin...

Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

The effects of repetitive transcranial magnetic stimulation in older adults with mild cognitive impairment: a protocol for a randomized, controlled three-arm trial

Mild Cognitive Impairment (MCI) carries a high risk of progression to Alzheimer’s disease (AD) dementia. Previous clinical trials testing whether cholinesterase inhibitors can slow the rate of progression from...

Authors: Joy L. Taylor, Benjamin C. Hambro, Nicole D. Strossman, Priyanka Bhatt, Beatriz Hernandez, J. Wesson Ashford, Jauhtai Joseph Cheng, Michael Iv, Maheen M. Adamson, Laura C. Lazzeroni and Margaret Windy McNerney

Recurrent episodes of reversible posterior leukoencephalopathy in three Chinese families with GJB1 mutations in X-linked Charcot-Marie-tooth type 1 disease: cases report

The X-linked form of Charcot-Marie-Tooth disease type 1 (CMTX1) is an inherited peripheral neuropathy that arises in patients with mutations in the gap-junction beta-1 gene (GJB1).

Authors: Youlong Liang, Jingli Liu, Daobin Cheng, Yu Wu, Liuhong Mo and Wen Huang

Recent transition of medical cost and relapse rate of multiple sclerosis in Japan based on analysis of a health insurance claims database

In this study, we aimed to understand the trends in total and itemized medical expenses, especially of disease-modifying therapy (DMT), for multiple sclerosis (MS) in Japan through an analysis of health insura...

Authors: Izumi Kawachi, Shuichi Okamoto, Mariko Sakamoto, Hiroyuki Ohta, Yusuke Nakamura, Kosuke Iwasaki, Manami Yoshida, Shinzo Hiroi and Mieko Ogino

An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study

In recent years, the role of neuroinflammation and oxidative stress in migraine pathogenesis has achieved considerable interest; however, to date findings are equivocal. Thus, the objective of this study was t...

Authors: Mansoureh Togha, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Amir Ghaemi and Pegah Rafiee

Case report on novel mutation in SPAST gene in Polish family with spastic paraplegia

Hereditary spastic paraplegia is a large group of degenerative, neurological disorders characterized by progressive lower limb spasticity and weakness. The disease was investigated precisely but still clinicia...

Authors: Aleksandra Klimkowicz-Mrowiec, Anna Dziubek, Malgorzata Sado, Marek Karpiński and Agnieszka Gorzkowska

Spinal cord infarction presenting as Brown-Séquard syndrome from spontaneous vertebral artery dissection: a case report and literature review

Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle...

Authors: Yang-Yang Meng, Le Dou, Chun-Mei Wang, De-Zheng Kong, Ying Wei, Li-Shan Wu, Yi Yang and Hong-Wei Zhou

Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis

X-linked agammaglobulinaemia (XLA) is a rare inherited primary immunodeficiency disease characterized by the B cell developmental defect, caused by mutations in the gene coding for Bruton’s tyrosine kinase (BT...

Authors: Ya-Ni Zhang, Yuan-Yuan Gao, Si-Da Yang, Bin-Bin Cao, Ke-Lu Zheng, Ping Wei, Lian-Feng Chen and Wen-Xiong Chen

Long-term deep-TMS does not negatively affect cognitive functions in stroke and spinal cord injury patients with central neuropathic pain

Authors: Priscila Mara Lorencini Selingardi, Antonia Lilian de Lima Rodrigues, Valquíria Aparecida da Silva, Diego Toledo Reis Mendes Fernandes, Jefferson Rosí Jr, Marco Antônio Marcolin, Lin T. Yeng, André R. Brunoni, Manoel J. Teixeira, Ricardo Galhardoni and Daniel Ciampi de Andrade

Epidemiology and health care utilization of patients suffering from Huntington’s disease in Germany: real world evidence based on German claims data

Huntington’s disease (HD) is a rare, genetic, neurodegenerative and ultimately fatal disease with no cure or progression-delaying treatment currently available. HD is characterized by a triad of cognitive, beh...

Authors: Christoph Ohlmeier, Kai-Uwe Saum, Wolfgang Galetzka, Dominik Beier and Holger Gothe

Malnutrition is common in children with cerebral palsy in Saudi Arabia – a cross-sectional clinical observational study

Cerebral palsy (CP) is considered as the main cause of severe physical impairment and malnutrition in children. This cross-sectional study intended to survey the nutritional status of children cerebral palsy i...

Authors: Abdul Rahman Almuneef, Ali Almajwal, Iftikhar Alam, Mahmoud Abulmeaty, Bader Al Bader, Mohamed Farouq Badr, May Almuammar and Suhail Razak

Autoregressive modeling to assess stride time pattern stability in individuals with Huntington’s disease

Huntington’s disease (HD) is a progressive, neurological disorder that results in both cognitive and physical impairments. These impairments affect an individual’s gait and, as the disease progresses, it signi...

Authors: Helia Mahzoun Alzakerin, Yannis Halkiadakis and Kristin D. Morgan

Endovascular treatment for acute basilar artery occlusion: a single center retrospective observational study

Endovascular treatment (EVT) is now considered the gold standard for select patient populations with anterior circulation stroke; however, data on the treatment of posterior circulation stroke are less clear. ...

Authors: Xuan Sun, Xu Tong, Feng Gao, Huiting Lao and Zhongrong Miao

Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial

The relevance of regular moderate to intense exercise for ameliorating psychomotor symptoms in persons with multiple sclerosis (pwMS) is becoming increasingly evident. Over the last two decades, emerging evide...

Authors: Sebastian Proschinger, Niklas Joisten, Annette Rademacher, Marit L. Schlagheck, David Walzik, Alan J. Metcalfe, Max Oberste, Clemens Warnke, Wilhelm Bloch, Alexander Schenk, Jens Bansi and Philipp Zimmer

Eosinophils and other peripheral blood biomarkers in glioma grading: a preliminary study

Many peripheral blood biomarkers are associated with glioma grade, but eosinophils (Eo) are scarcely reported. This study assessed preoperative peripheral eosinophil levels and other peripheral biomarkers pres...

Authors: Zhenxing Huang, Liang Wu, Zonggang Hou, Pengfei Zhang, Gen Li and Jian Xie

Contributing factors to quality of life after vertebral artery dissection: a prospective comparative study

Vertebral artery dissection (VAD) may cause cerebral ischemia and impair quality of life (QOL) despite of good functional outcome. The aim of this study was the multimodal analysis of patient characteristics a...

Authors: Rainer J. Strege, Reinhard Kiefer and Manfred Herrmann

Different imaging patterns of PCNSL and IVL: a case report

Primary central nervous system lymphoma (PCNSL) is a rare, malignant, non-Hodgkin’s lymphoma of the brain, leptomeninges, and rarely the spinal cord. PCNSL has characteristic magnetic resonance imaging (MRI) f...

Authors: Seung-Ho Jeon, Mi-Kyoung Kang, Seung Jae Lee, Byoung-Soo Shin and Hyun Goo Kang

Detecting delirium in patients with acute stroke: a systematic review of test accuracy

Patients with acute stroke are particularly vulnerable to delirium episodes. Although delirium detection is important, no evidence-based recommendations have been established to date on how these patients shou...

Authors: Irene Mansutti, Luisa Saiani and Alvisa Palese