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  1. The global burden of stroke epidemiology is changing rapidly. Over the 1990–2013 periods, there was a significant increase in the absolute number of deaths and incident events of stroke. The burden of stroke v...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:213

    Content type: Research article

    Published on:

  3. THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine o...

    Authors: Hee Jin Kim, Hanna Cho, Seongbeom Park, Hyemin Jang, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Seung Jun Oh, Minyoung Oh, Duk L. Na, Chul Hyoung Lyoo, Eun-Joo Kim, William W. Seeley, Jae Seung Kim, Kyung Chan Choi and Sang Won Seo

    Citation: BMC Neurology 2019 19:211

    Content type: Case report

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  4. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which is the most common type of autoimmune encephalitis, is caused by the production of autoantibodies against NMDA receptor. Anti-NMDAR encephali...

    Authors: Jie Lu, Ji-hong Zhang, Ai-liang Miao, Jun-xiong Yin, Dong-lin Zhu, Xing-jian Lin, Dao-wen Chen and Jing-ping Shi

    Citation: BMC Neurology 2019 19:210

    Content type: Case report

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  5. The Treatment Burden Questionnaire (TBQ) is a self-reported measure of the effect of treatment workload on patient wellbeing. We sought to validate the TBQ in Spanish and use it to estimate the burden of treat...

    Authors: María Célica Ysrraelit, Marcela Paula Fiol, Fernando Vazquez Peña, Sandra Vanotti, Sergio Adrián Terrasa, Viet-Thi Tran, Victor M. Montori and Jorge Correale

    Citation: BMC Neurology 2019 19:209

    Content type: Research article

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  7. Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence ...

    Authors: Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Hélène Cabanas and Sonya Marshall-Gradisnik

    Citation: BMC Neurology 2019 19:207

    Content type: Research article

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  8. Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote ischemic conditioning (RIC) reduces recurrence of ischemi...

    Authors: Zhangyuan Liao, Yali Bu, Meijie Li, Ranran Han, Nan Zhang, Junwei Hao and Wei Jiang

    Citation: BMC Neurology 2019 19:206

    Content type: Research article

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  9. Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality ha...

    Authors: Dereje Melka, Abenet Tafesse, James H. Bower and Demeke Assefa

    Citation: BMC Neurology 2019 19:205

    Content type: Research article

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  11. Vanishing white matter disease (VWMD) is one of the most prevalent inherited leukoencephalopathies, which generally presents in childhood as a progressive disorder while less beginning in adulthood. The presen...

    Authors: Cuibai Wei, Qi Qin, Fei Chen, Aihong Zhou, Fen Wang, Xiumei Zuo, Rong Chen, Jihui Lyu and Jianping Jia

    Citation: BMC Neurology 2019 19:203

    Content type: Case report

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  12. Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei pro...

    Authors: Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu and Zuxun Lu

    Citation: BMC Neurology 2019 19:202

    Content type: Research article

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  14. Primary central nervous system (CNS) small lymphocytic lymphoma (SLL), as a type of low-grade lymphoma, is extremely rare. The diagnosis of CNS SLL is challenging due to its variable clinical and radiological ...

    Authors: Rongjing Guo, Xiaolong Zhang, Chunxiao Niu, Yibin Xi, Hong Yin, Hong Lin and Ting Chang

    Citation: BMC Neurology 2019 19:200

    Content type: Case report

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  15. Following publication of the original article [1], the authors reported errors in reference citations found in Table 1.

    Authors: Carolin Siegert, Björn Hauptmann, Nicole Jochems, Andreas Schrader and Ruth Deck

    Citation: BMC Neurology 2019 19:199

    Content type: Correction

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    The original article was published in BMC Neurology 2019 19:143

  16. Myofibrillar myopathies (MFMs) are a genetically heterogeneous group of muscle disorders. Mutations in the filamin C gene (FLNC) have previously been identified in patients with MFM. The phenotypes of FLNC-relate...

    Authors: Juanjuan Chen, Jun Wu, Chunxi Han, Yao Li, Yuzu Guo and Xiaoxin Tong

    Citation: BMC Neurology 2019 19:198

    Content type: Case report

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  17. Mechanical thrombectomy (MT) using stent retriever assisted vacuum-locked extraction (SAVE) is a promising method for anterior circulation strokes. We present our experience with SAVE for large vessel occlusio...

    Authors: Volker Maus, Hanna Styczen, Jan Liman, Ilko Maier, Alex Brehm, Ioannis Tsogkas and Marios-Nikos Psychogios

    Citation: BMC Neurology 2019 19:197

    Content type: Research article

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  18. Recovery of upper limb function in individuals after a stroke remains challenging. Modified constraint-induced movement therapy (m-CIMT) has strong evidence for increasing the use and recovery of sensorimotor ...

    Authors: Erika Shirley Moreira da Silva, Gabriela Lopes Santos, Aparecida Maria Catai, Alexandra Borstad, Natália Pereira Duarte Furtado, Isabela Arruda Verzola Aniceto and Thiago Luiz Russo

    Citation: BMC Neurology 2019 19:196

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in BMC Neurology 2019 19:225

  19. Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality ...

    Authors: Talha Mubashir, Lusine Abrahamyan, Ayan Niazi, Deween Piyasena, Abdul A. Arif, Jean Wong, Ricardo S. Osorio, Clodagh M. Ryan and Frances Chung

    Citation: BMC Neurology 2019 19:195

    Content type: Research article

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  21. Emotional processes and responses are underestimated in stroke patients because the massive clinical picture of large hemispheric strokes often hides these symptoms. We report on a patient with peculiar unplea...

    Authors: Mariagiovanna Cantone, Giuseppe Lanza, Rita Bella, Giovanni Pennisi, Paola Santalucia, Placido Bramanti and Manuela Pennisi

    Citation: BMC Neurology 2019 19:193

    Content type: Case report

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  22. Neurological disorders are the most common cause of morbidity and mortality in developing countries. Available evidence on urban–rural differences on neurological diseases is scare in such countries. Our study...

    Authors: Safia Awan, Alam Ibrahim Siddiqi, Ahmed Asif, Naveeduddin Ahmed, Hazim Brohi, Sajad Jalbani and Mohammad Wasay

    Citation: BMC Neurology 2019 19:192

    Content type: Research article

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  23. We studied the efficacy and safety of a second dose of lasmiditan for acute treatment of migraine.

    Authors: Li Shen Loo, Brian M. Plato, Ira M. Turner, Michael G. Case, Joel Raskin, Sherie A. Dowsett and John H. Krege

    Citation: BMC Neurology 2019 19:191

    Content type: Research article

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  24. Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod.

    Authors: Tim Sinnecker, Jeffrie Hadisurya, Tilman Schneider-Hohendorf, Nicholas Schwab, Karsten Wrede, Oliver Gembruch, Ralf Gold, Kerstin Hellwig, Sara Pilgram-Pastor, Ortwin Adams, Philipp Albrecht, Hans-Peter Hartung, Orhan Aktas and Markus Kraemer

    Citation: BMC Neurology 2019 19:190

    Content type: Case report

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  25. Lumbosacral lipomas (LLs) may remain asymptomatic or lead to progressive neurological deterioration. However, sudden neurological deterioration is a rare and severe event. Herein, we report rare occurrences of...

    Authors: Luca Massimi, Thailane Maria Feitosa Chaves, François Yves Legninda Sop, Paolo Frassanito, Gianpiero Tamburrini and Massimo Caldarelli

    Citation: BMC Neurology 2019 19:189

    Content type: Case report

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  26. Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies reported several novel PSEN1 mutations among Asian. We describe a male with EOAD had a ...

    Authors: Vo Van Giau, Jung-Min Pyun, Jeewon Suh, Eva Bagyinszky, Seong Soo A. An and Sang Yun Kim

    Citation: BMC Neurology 2019 19:188

    Content type: Case report

    Published on:

  27. Stroke is the second-leading global cause of death behind heart disease in 2013 and is a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing ...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:187

    Content type: Research article

    Published on:

  28. The topographic location of acute pontine infarction is associated with clinical syndromes and prognosis. Previous studies focused on isolated pontine infarction, but the topographic location of unisolated pon...

    Authors: Jiehong Huang, Zhihua Qiu, Piansi Zhou, Jianming Li, Yingxin Chen, Ruiyun Huang, Chujing Li, Xilin Ouyang, Huazhuo Feng, Hanqing Xu, Dezhi Liu, Zheng Dai, Juehua Zhu, Xinfeng Liu, Hongbing Chen and Yongjun Jiang

    Citation: BMC Neurology 2019 19:186

    Content type: Research article

    Published on:

  29. Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) re...

    Authors: Chun-Sheng Yang, Qiu xia Zhang, Yu Deng, Bing jie Zhou, Lin jie Zhang, Li min Li, Yuan Qi, Jing Wang, Li Yang and Fu-Dong Shi

    Citation: BMC Neurology 2019 19:185

    Content type: Research article

    Published on:

  30. Pembrolizumab is an immune-checkpoints inhibitor that enhances the immune response against cancer cells and therefore is useful for the treatment of several carcinomas. However, pembrolizumab sometimes perturb...

    Authors: Hikaru Kamo, Taku Hatano, Kazuaki Kanai, Nozomi Aoki, Daiki Kamiyama, Kazumasa Yokoyama, Masashi Takanashi, Yuri Yamashita, Yasushi Shimo and Nobutaka Hattori

    Citation: BMC Neurology 2019 19:184

    Content type: Case report

    Published on:

  31. Stroke is the second-leading global cause of death behind heart disease in 2013 and is a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing ...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:183

    Content type: Research article

    Published on:

  32. Hypothalamic lesions, such as tumors and demyelinating diseases, reportedly cause abnormal sleepiness. However, stroke involving the hypothalamus has rarely been described. Here, we report a patient with infar...

    Authors: Takeo Matsubara, Keisuke Suzuki, Akiko Kawasaki, Masayuki Miyamoto, Madoka Okamura, Takashi Kanbayashi, Hidehiro Takekawa, Toshiki Nakamura, Yuji Watanabe, Masanori Matsubara and Koichi Hirata

    Citation: BMC Neurology 2019 19:182

    Content type: Case report

    Published on:

  33. Optimizing thrombolytic therapy is vital for improving stroke outcomes. We aimed to develop standardized thrombolysis conditions to evaluate the efficacy of tenecteplase (TNK) compared to the current gold stan...

    Authors: Tobias Frühwald, Ulrich Gärtner, Nils Stöckmann, Jan-Henning Marxsen, Carolin Gramsch and Florian C. Roessler

    Citation: BMC Neurology 2019 19:181

    Content type: Research article

    Published on:

  34. This study examined how intracranial large artery stenosis (ILAS), symptomatic and asymptomatic ILAS, and risk factors affect unfavorable outcome events after medical treatment in routine clinical practice.

    Authors: K. C. Chang, I. C. Chuang, Y. C. Huang, C. Y. Wu, W. C. Lin, Y. L. Kuo, T. H. Lee and S. J. Ryu

    Citation: BMC Neurology 2019 19:180

    Content type: Research article

    Published on:

  35. Cognitive dysfunction is highly prevalent in Parkinson’s disease (PD) and a large proportion of patients eventually develops PD-related dementia. Currently, no effective treatment is available. Cognitive train...

    Authors: Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Iris Zijlstra, Rob H. Hagen, Tanja Berk, Chris Vriend and Odile A. van den Heuvel

    Citation: BMC Neurology 2019 19:179

    Content type: Study protocol

    Published on:

  36. B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a...

    Authors: Estelle E. Seyman, Natan Bornstein, Eitan Auriel, Oren Cohen, Tania Nissel and Hen Hallevi

    Citation: BMC Neurology 2019 19:178

    Content type: Research article

    Published on:

  37. Insulin resistance (IR) in relation to diabetes is a risk factor for ischemic stroke (IS), whereas less is known about non-diabetic IR and outcome after IS.

    Authors: Daniel Åberg, N. David Åberg, Katarina Jood, Lukas Holmegaard, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern and Johan Svensson

    Citation: BMC Neurology 2019 19:177

    Content type: Research article

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  39. Elevated levels of plasma D-dimer increase the risk of ischemic stroke, stroke severity, and the progression of stroke status, but the association between plasma D-dimer level and functional outcome is unclear...

    Authors: Tao Yao, Bo-Lin Tian, Gang Li, Qin Cui, Cui-fang Wang, Qi Zhang, Bo Peng, Yan Gao, Yan-Qiang Zhan, Dan Hu, Lu Xu and Gao-Hua Wang

    Citation: BMC Neurology 2019 19:175

    Content type: Research article

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  40. Tardive dyskinesia (TD) is a serious, often irreversible movement disorder caused by prolonged exposure to antipsychotics; identifying patients at risk for TD is critical to preventing it. Predictive models fo...

    Authors: Oscar Patterson-Lomba, Rajeev Ayyagari and Benjamin Carroll

    Citation: BMC Neurology 2019 19:174

    Content type: Research article

    Published on:

  41. Multiple sclerosis (MS) patients often struggle with treatment decisions, in part due to the increasing number of approved disease modifying therapies, each with different characteristics, and also since physi...

    Authors: Nick Bansback, Judy A. Chiu, Robert Carruthers, Rebecca Metcalfe, Emmanuelle Lapointe, Alice Schabas, Marilyn Lenzen, Larry D. Lynd and Anthony Traboulsee

    Citation: BMC Neurology 2019 19:173

    Content type: Research article

    Published on:

  43. Spinal cord injury (SCI) is a life-changing experience for the individuals with SCI and their families. This study aimed to investigate physical strategies used for overcoming physical disability in individual...

    Authors: Alireza Nikbakht-Nasrabadi, Nooredin Mohammadi, Manijeh Yazdanshenas and Maryam Shabany

    Citation: BMC Neurology 2019 19:171

    Content type: Research article

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  44. Myasthenia gravis is the most common disease affecting the neuromuscular junction. The most common etiology among patients with juvenile myasthenia gravis is the production of antibodies against the acetylchol...

    Authors: Cheng-Che Chou, I-Chen Su, I-Jun Chou, Jainn-Jim Lin, Shih-Yun Lan, Yi-Shan Wang, Shu-Sing Kong, Yun-Ju Chen, Meng-Ying Hsieh, Po-Cheng Hung, Huei-Shyong Wang, Min-Liang Chou and Kuang-Lin Lin

    Citation: BMC Neurology 2019 19:170

    Content type: Research article

    Published on:

  46. The coexistence of distinct neurodegenerative diseases in single cases has recently attracted greater attention. The phenotypic co-occurrence of progressive supranuclear palsy (PSP) and amyotrophic lateral scl...

    Authors: Koji Fujita, Tomoyasu Matsubara, Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Keiko Maruyama Saladini, Toshitaka Kawarai, Hiroyuki Nodera, Fukashi Udaka, Kodai Kume, Hiroyuki Morino, Hideshi Kawakami, Masato Hasegawa, Ryuji Kaji, Shigeo Murayama and Yuishin Izumi

    Citation: BMC Neurology 2019 19:168

    Content type: Case report

    Published on:

  47. Higher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 early after ischemic stroke have been associated with lower survival. The objectives of this study were to determine serum TI...

    Authors: Leonardo Lorente, María M. Martín, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Alejandro Jiménez, Juan M. Borreguero-León, Agustín F. González-Rivero, Josune Orbe, José A. Rodríguez and José A. Páramo

    Citation: BMC Neurology 2019 19:167

    Content type: Research article

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  48. Acquired epileptiform opercular syndrome (AEOS) with electrical status epilepticus during sleep (ESES) may be recurrent and intractable. The real-time transcranial Doppler ultrasound–sleep-deprived video elect...

    Authors: Bing-Wei Peng, Hui-Ci Liang, Jia-Ling Li, Si-Yuan Yang, Wei Liang, Feng-Qiong Zhang and Wen-Xiong Chen

    Citation: BMC Neurology 2019 19:166

    Content type: Case report

    Published on:

  49. The exact relationship between 25-hydroxyvitamin D [25(OH) D] levels and small vessel disease (SVD) are not clear in China. The aim of this study was to determine such the association between 25(OH) D and SVD ...

    Authors: Junzeng Si, Kuibao Li, Peiyan Shan and Junliang Yuan

    Citation: BMC Neurology 2019 19:164

    Content type: Research article

    Published on:

  50. Patients with vertebrobasilar dolichoectasia usually have persistent hemodynamic abnormalities, and therefore, may bear an increased risk of stroke. This study aimed to identify risk factors for stroke recurre...

    Authors: Zhaoyao Chen, Shuai Zhang, Zhengze Dai, Xi Cheng, Minghua Wu, Qiliang Dai, Xinfeng Liu and Gelin Xu

    Citation: BMC Neurology 2019 19:163

    Content type: Research article

    Published on:

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