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  1. Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI)...

    Authors: Kevin Akeret, Raphael M. Buzzi, Moritz Saxenhofer, Kathrin Bieri, Deborah Chiavi, Bart R. Thomson, Manuela Grüttner-Durmaz, Nina Schwendinger, Rok Humar, Luca Regli, Tristan P. C. van Doormaal, Ulrike Held, Emanuela Keller, Michael Hugelshofer and Dominik J. Schaer
    Citation: BMC Neurology 2022 22:267
    Content type: Study protocol Published on:

  2. The worldwide prevalence of dementia is rapidly rising. Alzheimer’s disease (AD), accounts for 70% of cases and has a 10–20-year preclinical period, when brain pathology covertly progresses before cognitive sy...

    Authors: Jane Alty, Quan Bai, Renjie Li, Katherine Lawler, Rebecca J. St George, Edward Hill, Aidan Bindoff, Saurabh Garg, Xinyi Wang, Guan Huang, Kaining Zhang, Kaylee D. Rudd, Larissa Bartlett, Lynette R. Goldberg, Jessica M. Collins, Mark R. Hinder…
    Citation: BMC Neurology 2022 22:266
    Content type: Study protocol Published on:

  3. Primary familial brain calcification (PFBC) is a rare inherited neurological disorder characterized by bilateral basal ganglia calcification with a series of motor and nonmotor symptoms. Mutations in the SLC20A2 ...

    Authors: Weiting Bu, Lijing Hou, Meijia Zhu, Renyun Zhang, Xiaoyu Zhang, Xiao Zhang, Jiyou Tang and Xiaomin Liu
    Citation: BMC Neurology 2022 22:265
    Content type: Case report Published on:

  4. Stent-assisted coiling (SAC) has been reported as a feasible and effective treatment of wide-neck cerebral aneurysms. However, the evidence of SAC of ruptured cerebral aneurysm is lacking. There are no prospec...

    Authors: Gaozhi Li, Yongquan Han, Shenghao Ding, Yaohua Pan, Xiaohua Zhang and Bing Zhao
    Citation: BMC Neurology 2022 22:264
    Content type: Study protocol Published on:

  5. Evidence regarding the relationship between serum triglyceride-to-high density lipoprotein cholesterol (TG/HDL-c) ratio and outcomes in acute ischemic stroke (AIS) patients is still mixed. Therefore, the prese...

    Authors: Yong Han, Zhiqiang Huang, Jinsong Zhou, Zhibin Wang, Qiming Li, Haofei Hu and Dehong Liu
    Citation: BMC Neurology 2022 22:263
    Content type: Research Published on:

  6. Parkinson’s disease (PD) is a neurodegenerative disease, for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based therapy might have short- and long-term ben...

    Authors: Jules M. Janssen Daalen, Marjan J. Meinders, Federica Giardina, Kit C. B. Roes, Bas C. Stunnenberg, Soania Mathur, Philip N. Ainslie, Dick H. J. Thijssen and Bastiaan R. Bloem
    Citation: BMC Neurology 2022 22:262
    Content type: Study protocol Published on:

  7. Lumbar puncture (LP) is a common and relatively safe neurological procedure. It can be complicated by post-dural puncture headache (PDPH) after both diagnostic and therapeutic procedures. The aim of this study...

    Authors: Jasem Al-Hashel, Azza Rady, Fathi Massoud and Ismail Ibrahim Ismail
    Citation: BMC Neurology 2022 22:261
    Content type: Research article Published on:

  8. Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the gradual loss of upper and lower motor neurons that leads to progressive muscle atrophy and weakness. Edaravone, a ...

    Authors: Jin-Mo Park, Donghwi Park, Hyung-Jun Kim and Jin-Sung Park
    Citation: BMC Neurology 2022 22:260
    Content type: Research article Published on:

  9. Cerebral venous infarction (CVI) is a serious complication after meningioma resection. The risk factors of postoperative cerebral venous infarction after surgical resection of meningioma can be determined thro...

    Authors: Qing Cai, Shoujie Wang, Min Zheng, Xuejiao Wang, Rong Liu, Liqin Liu, Huaizhou Qin and Dayun Feng
    Citation: BMC Neurology 2022 22:259
    Content type: Research article Published on:

  10. To describe technical features and initial results of a novel large-bore reperfusion catheter as first thromboaspiration approach for endovascular stroke treatment in terminal internal carotid artery (T-ICA) o...

    Authors: Daniele Giuseppe Romano, Giulia Frauenfelder, Francesco Diana and Renato Saponiero
    Citation: BMC Neurology 2022 22:258
    Content type: Research article Published on:

  11. Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally-inherited mitochondrial disease that primarily affects retinal ganglion cells (RGCs) and their axons in the optic nerve, leading to irreversible, ...

    Authors: Nancy J. Newman, Matthew Schniederjan, Pia R. Mendoza, David J. Calkins, Patrick Yu-Wai-Man, Valérie Biousse, Valerio Carelli, Magali Taiel, Francois Rugiero, Pramila Singh, Alexandra Rogue, José-Alain Sahel and Philippe Ancian
    Citation: BMC Neurology 2022 22:257
    Content type: Case report Published on:

  12. Risk-stratification tools that have been developed to identify transient ischemic attack (TIA) patients at risk of recurrent vascular events typically include factors which are not readily available in electro...

    Authors: Laura J. Myers, Anthony J. Perkins, Ying Zhang and Dawn M. Bravata
    Citation: BMC Neurology 2022 22:256
    Content type: Research Published on:

  13. Although the characteristics of intracranial aneurysms (IAs) in different age groups have been well documented, they remain relatively unclear in elderly patients due to a lack of large sample studies.

    Authors: Ruiqi Chen, Dingke Wen, Anqi Xiao, Rui Guo, Chao You and Yi Liu
    Citation: BMC Neurology 2022 22:255
    Content type: Research article Published on:

  14. The dopaminergic system modulates growth hormone secretion and previous results have suggested a link between short stature and an increased risk of Parkinson’s disease (PD).

    Authors: Laura Saari, Emmilotta A. Backman, Pia Wahlsten, Maria Gardberg and Valtteri Kaasinen
    Citation: BMC Neurology 2022 22:254
    Content type: Research Published on:

  15. Neurological manifestations of COVID-19 are thought to be associated with the disease severity of COVID-19 and poor clinical outcomes. Dysregulated immune responses are considered to be mediating such complica...

    Authors: Seungyon Koh, Yoon Seob Kim, Min Hye Kim, Young Hwa Choi, Jun Young Choi and Tae-Joon Kim
    Citation: BMC Neurology 2022 22:253
    Content type: Case report Published on:

  16. To compare the effectiveness of dimethyl fumarate (DMF) with subcutaneous interferon beta-1a (IFNβ-1a) in controlling disease activity in patients with relapsing–remitting Multiple Sclerosis (MS).

    Authors: Neda Sattarnezhad, Brian C. Healy, Moogeh Baharnoori, Camilo Diaz-Cruz, James Stankiewicz, Howard L. Weiner and Tanuja Chitnis
    Citation: BMC Neurology 2022 22:252
    Content type: Research Published on:

  17. Eptinezumab is an anti-calcitonin gene-related peptide humanized monoclonal antibody approved for the preventive treatment of migraine in adults. The PREVAIL study demonstrated a favorable safety profile with ...

    Authors: Andrew Blumenfeld, Anders Ettrup, Joe Hirman, Bjarke Ebert and Roger Cady
    Citation: BMC Neurology 2022 22:251
    Content type: Research Published on:

  18. In seizure-naive brain tumor patients, the efficacy of perioperative prophylactic antiepileptic drug treatment remains controversial. In case of administration, the common preferred drug is levetiracetam (LEV)...

    Authors: Elias Konrath, Franz Marhold, Wolfgang Kindler, Florian Scheichel, Branko Popadic, Katrin Blauensteiner, Bernadette Calabek, Elisabeth Freydl, Michael Weber, Robin Ristl, Katharina Hainz, Camillo Sherif and Stefan Oberndorfer
    Citation: BMC Neurology 2022 22:250
    Content type: Research Published on:

  19. In recent years, alkaline phosphatase (ALP) has been considered as one of the independent risk factors of acute ischemic stroke (AIS) and leads to worse clinical outcomes in patients with renal failure. In thi...

    Authors: Zhongzhong Liu, Xuemei Lin, Lingxia Zeng, Qingli Lu, Pei Liu, Jing Wang, Yan Liu, Qiaoqiao Chang, Yan Wang, Chensheng Song, Fang Wang, Yaling Shi, Guozheng Liu, Qing Wang and Songdi Wu
    Citation: BMC Neurology 2022 22:249
    Content type: Research Published on:

  20. Cerebral venous sinus thrombosis (CVST) is an uncommon cerebrovascular disease with diverse predisposing factors. We report a case of CVST caused by a thyroid storm induced by traumatic brain injury.

    Authors: Shurong Gong, Wenyao Hong, Jiafang Wu, Jinqing Xu, Jianxiang Zhao, Xiaoguang Zhang, Yuqing Liu and Rong-Guo Yu
    Citation: BMC Neurology 2022 22:248
    Content type: Case report Published on:

  21. Cryptococcal meningoencephalitis (CM) is a severe infection of central nervous system with high mortality and morbidity. Infection-related inflammatory syndrome is a rare complication of CM. Herein, we report ...

    Authors: Xiao-Hong Su, Wei-Peng Li, Qi Lin, Xiu-Jun Zheng, Ting Fang, Ying Jiang and Fu-Hua Peng
    Citation: BMC Neurology 2022 22:247
    Content type: Case report Published on:

  22. Children with cerebral palsy (CP) often have communication impairments, including speech altered intelligibility. Multiple levels of disrupted speech have been reported in CP, which negatively impact on partic...

    Authors: S. Fiori, C. Ragoni, I. Podda, A. Chilosi, C. Amador, P. Cipriani, A. Guzzetta and G. Sgandurra
    Citation: BMC Neurology 2022 22:246
    Content type: Study protocol Published on:

  23. Patient involvement in discharge planning of patients with stroke can be accomplished by providing personalized outcome information and promoting shared decision-making. The aim of this study was to develop a ...

    Authors: J. C. M. Prick, S. M. van Schaik, I. A. Deijle, R. Dahmen, P. J. A. M. Brouwers, P. H. E. Hilkens, M. M. Garvelink, N. Engels, J. W. Ankersmid, S. H. J. Keus, R. The, A. Takahashi, C. F. van Uden-Kraan, P. J. van der Wees and R. M. Van den Berg-Vos
    Citation: BMC Neurology 2022 22:245
    Content type: Research Published on:

  25. Oculopharyngodistal myopathy (OPDM) is an adult-onset neuromuscular disease characterized by progressive ocular, facial, pharyngeal, and distal limb muscle involvement. Recent research showed that GGC repeat e...

    Authors: Guang Ji, Yuan Zhao, Jian Zhang, Hui Dong, Hongran Wu, Xian Chen, Xiaoming Qi, Yun Tian, Lu Shen, Guofeng Yang and Xueqin Song
    Citation: BMC Neurology 2022 22:243
    Content type: Case report Published on:

    The Correction to this article has been published in BMC Neurology 2022 22:295

  26. Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central ner...

    Authors: Jing Lin, Min Zhu, Xiaocheng Mao, Zeqing Jin, Meihong Zhou and Daojun Hong
    Citation: BMC Neurology 2022 22:242
    Content type: Case report Published on:

  27. Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment for acute myeloid leukemia. However, extramedullary relapse of acute myeloid leukemia can occur after hematopoietic stem c...

    Authors: Shogo Shirota, Daisuke Katoh, Yoshimitsu Shimomura, Yukihiro Imai and Takayuki Ishikawa
    Citation: BMC Neurology 2022 22:241
    Content type: Case report Published on:

  28. Gait disturbances may appear prior to cognitive dysfunction in the early stage of silent cerebrovascular disease (SCD). Subtle changes in gait characteristics may provide an early warning of later cognitive de...

    Authors: Yan-min Tang, Bei-ni Fei, Xin Li, Jin Zhao, Wei Zhang, Guo-you Qin, Min Hu, Jing Ding and Xin Wang
    Citation: BMC Neurology 2022 22:240
    Content type: Study protocol Published on:

  29. Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) often receive delayed or no aneurysm treatment, although recent studies suggest that functional outcome following early aneurysm treatment has...

    Authors: Jordi de Winkel, Tim Y. Cras, Ruben Dammers, Pieter-Jan van Doormaal, Mathieu van der Jagt, Diederik W. J. Dippel, Hester F. Lingsma and Bob Roozenbeek
    Citation: BMC Neurology 2022 22:239
    Content type: Research Published on:

  30. Stroke is one of the most frequent diseases, and half of the stroke survivors are left with permanent impairment. Prediction of individual outcome is still difficult. Many but not all patients with stroke impr...

    Authors: Corinna Blum, David Baur, Lars-Christian Achauer, Philipp Berens, Stephanie Biergans, Michael Erb, Volker Hömberg, Ziwei Huang, Oliver Kohlbacher, Joachim Liepert, Tobias Lindig, Gabriele Lohmann, Jakob H. Macke, Jörg Römhild, Christine Rösinger-Hein, Brigitte Zrenner…
    Citation: BMC Neurology 2022 22:238
    Content type: Study protocol Published on:

  31. Intraplaque hemorrhage (IPH) is a hallmark of carotid plaque vulnerability. We aim to investigate the association between IPH and recurrent ipsilateral ischemic stroke.

    Authors: Fengli Che, Donghua Mi, Anxin Wang, Yi Ju, Binbin Sui, Xiaokun Geng, Xihai Zhao and Xingquan Zhao
    Citation: BMC Neurology 2022 22:237
    Content type: Research Published on:

  32. Stress hyperglycemia is a common condition in patients suffering from critical illness such as spontaneous intracerebral hemorrhage (ICH). Our study aimed to use glucose-to-glycated hemoglobin (HbA1c) ratio to...

    Authors: Sijia Li, Yu Wang, Wenjuan Wang, Qian Zhang, Anxin Wang and Xingquan Zhao
    Citation: BMC Neurology 2022 22:236
    Content type: Research Published on:

  33. Many patients with neurological disorders experience chronic fatigue, but the neural mechanisms involved are unclear.

    Authors: Ying Zhang, Hong-xi Chen, Zi-yan Shi, Qin Du, Jian-cheng Wang, Xiao-fei Wang, Yu-han Qiu, Yan-lin Lang, Ling-yao Kong, Lin-jun Cai, Xue Lin, Zi-chao Mou, Wen-qin Luo, Shuang-jie Li and Hong-yu Zhou
    Citation: BMC Neurology 2022 22:235
    Content type: Research Published on:

  34. Delirium, a common complication after stroke, is often overlooked, and long-term consequences are poorly understood. This study aims to explore whether delirium in the acute phase of stroke predicts cognitive ...

    Authors: Vilde Nerdal, Elise Gjestad, Ingvild Saltvedt, Ragnhild Munthe-Kaas, Hege Ihle-Hansen, Truls Ryum, Stian Lydersen and Ramune Grambaite
    Citation: BMC Neurology 2022 22:234
    Content type: Research Published on:

  35. The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN). 

    Authors: Anna Maria Florescu, Anne Louise Tølbøll Sørensen, Henrik Vedel Nielsen, Daniel Tolnai, Lene Dissing Sjö, Katja Lohmann Larsen and Mohammad Al-Mahdi Al-Karagholi
    Citation: BMC Neurology 2022 22:233
    Content type: Case report Published on:

  36. Insulin has been demonstrated to play an important role in the occurrence and development of Alzheimer’s disease, especially in those with diabetes. β cells are important insulin-producing cells in human pancr...

    Authors: Mengyi Guo, Jiaokun Jia, Jia Zhang, Mingyue Zhou, Anxin Wang, Shengyun Chen and Xingquan Zhao
    Citation: BMC Neurology 2022 22:232
    Content type: Research Published on:

  37. Stroke is the main cause of oropharyngeal neurogenic dysphagia. Electrostimulation has been used as a therapeutic tool in these cases. However, there are few studies that prove its effectiveness. We evaluated ...

    Authors: Klayne Cunha Matos, Vanessa Fernandes de Oliveira, Paula Luanna Carvalho de Oliveira, Fabíola Aureliano Carvalho, Maria Renata Matos de Mesquita, Camila Gabriella da Silva Queiroz, Levi Mota Marques, Débora Lilian Nascimento Lima, Fernanda Martins Maia Carvalho and Pedro Braga-Neto
    Citation: BMC Neurology 2022 22:231
    Content type: Research Published on:

  38. Psychological interventions are shown to be effective in migraine, but not utilized routinely yet. We aimed to evaluate the efficacy of transdiagnostic cognitive behavioral therapy (TCBT) on people with migrai...

    Authors: Forouzandeh Soleimanian-Boroujeni, Negin Badihian, Shervin Badihian, Vahid Shaygannejad and Yousef Gorji
    Citation: BMC Neurology 2022 22:230
    Content type: Research Published on:

  40. As endovascular thrombectomy (EVT) is time-dependent, it is crucial to refer patients promptly. Current referral modes include Mothership (MS), Drip and Ship (DS) and Drive the Doctor (DD). The purpose of this...

    Authors: Jie Hou, Zhi-liang Guo, Zhi-chao Huang, Huai-shun Wang, Shou-jiang You and Guo-dong Xiao
    Citation: BMC Neurology 2022 22:228
    Content type: Research Published on:

  41. Ischemic stroke is the most common presentation of cervical artery dissection (CAD). Information regarding CAD-induced stroke is scarce, especially in the Middle East. Here we investigated the incidence of CAD...

    Authors: Mahta Ranjbar, Negin Badihian, Maryam Yazdi, Shahaboddin Milani, Marzieh Taheri, Fariborz Khorvash and Mohammad Saadatnia
    Citation: BMC Neurology 2022 22:227
    Content type: Research Published on:

  42. Patients with bone metastasis often experience severe pain that is difficult to control and seriously affects quality of life. Radiotherapy is an effective way to relieve pain in these patients. Currently, the...

    Authors: Li Yuan, Lidan Geng, Danfeng Wu, Tangzhi Dai, Gang Feng and Xiaobo Du
    Citation: BMC Neurology 2022 22:226
    Content type: Study protocol Published on:

  43. Posterior reversible encephalopathy syndrome (PRES) is a disorder of reversible vasogenic brain oedema with acute neurologic symptoms. It is a rare but serious disease that affects the central nervous system. ...

    Authors: Bazhu, Yanhui Shi, Shuang Ren, Liang Shu and Qiang Li
    Citation: BMC Neurology 2022 22:225
    Content type: Case report Published on:

  44. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common type of autoimmune encephalitis. Patients with this condition are frequently very ill but are often misdiagnosed in the Emergency Depart...

    Authors: Jin Xu, Na Zhao, Hongzhi Guan, Joseph Harold Walline, Huadong Zhu and Xuezhong Yu
    Citation: BMC Neurology 2022 22:224
    Content type: Research Published on:

  45. Eccrine spiradenocarcinoma (SC), also known as malignant eccrine spiradenoma, is a rare malignant cutaneous adnexal neoplasm arising from long-standing benign eccrine spiradenoma. Malignant skin tumors rarely ...

    Authors: Yuji Kibe, Kuniaki Tanahashi, Kazuhiro Ohtakara, Yuka Okumura, Fumiharu Ohka, Kazuhito Takeuchi, Yuichi Nagata, Kazuya Motomura, Sho Akahori, Akihiro Mizuno, Hiroo Sasaki, Hiroyuki Shimizu, Junya Yamaguchi, Tomohide Nishikawa, Kenji Yokota and Ryuta Saito
    Citation: BMC Neurology 2022 22:223
    Content type: Case report Published on:

  46. Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disease predominantly found in women of child-bearing age. Neurogenic pulmonary edema (NPE) is a recalcitrant complication th...

    Authors: Rongqi Li, Yingai Wang, Xiuhua Wu, Junping Wang, Wei Wei and Xin Li
    Citation: BMC Neurology 2022 22:222
    Content type: Case report Published on:

  47. Erenumab is a fully human monoclonal antibody and a highly potent, first-in-class calcitonin gene-related peptide receptor inhibitor approved for migraine prevention in adults. Randomised, placebo-controlled t...

    Authors: Taoufik Alsaadi, Suzan Noori, Razmig Varakian, Saly Youssef and AbuBaker Almadani
    Citation: BMC Neurology 2022 22:221
    Content type: Research Published on:

  48. Upper limb (UL) paresis is one of the most common stroke consequences and significantly restricts patients in everyday life. Instruments objectively measuring direct arm use in stroke patients are lacking, but...

    Authors: Anne-Lisa Heye, Christine Kersting, Malte Kneer and Anne Barzel
    Citation: BMC Neurology 2022 22:220
    Content type: Research article Published on:
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