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  1. Insufficient amounts of physical activity is a risk factor for (recurrent) stroke. People with a stroke or transient ischemic attack (TIA) have a high risk of recurrent stroke and have lower levels of physical...

    Authors: Wendy Hendrickx, Lara Vlietstra, Karin Valkenet, Roderick Wondergem, Cindy Veenhof, Coralie English and Martijn Frits Pisters

    Citation: BMC Neurology 2020 20:168

    Content type: Research article

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  2. Short-chain enoyl-CoA hydratase (ECHS1) is a multifunctional mitochondrial matrix enzyme involved in the second step of mitochondrial fatty acid β-oxidation. Mitochondrial diseases resulting from ECHS1 mutations ...

    Authors: Miaojuan Wu, Wenqi Gao, Zhifang Deng, Zhisheng Liu, Jiehui Ma, Han Xiao, Yu Xu and Dan Sun

    Citation: BMC Neurology 2020 20:165

    Content type: Case report

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  3. Lithium is primarily used to treat bipolar disorder and is known to cause several acute neurological complications. Reversible splenial lesions (RSLs) may be evident in antiepileptic drug toxicity or withdrawa...

    Authors: Han Uk Ryu, Ji Yeon Chung, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2020 20:164

    Content type: Case report

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  4. Research is needed to examine differences in multiple sclerosis (MS) prevalence by race-ethnicity. The goal of this study was to quantify MS prevalence in a health care system in Northern California and examin...

    Authors: Robert J. Romanelli, Qiwen Huang, Joseph Lacy, Lobat Hashemi, Alana Wong and Alden Smith

    Citation: BMC Neurology 2020 20:163

    Content type: Research article

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  5. Spinal cerebrospinal fluid (CSF) leak can lead to intracranial hypotension and is an important differential diagnosis to consider in patients with sudden-onset chronic daily headaches. Pars interarticularis (P...

    Authors: Tommy Lik Hang Chan, Robert Cowan, Nada Hindiyeh, Syed Hashmi, Bryan Lanzman and Ian Carroll

    Citation: BMC Neurology 2020 20:162

    Content type: Research article

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  6. We investigated the gait characteristics of patients with Parkinson’s disease (PD), under free-living conditions, using a wearable device, and assessed their relationships with global cognitive function and mo...

    Authors: Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Yoshihiko Okubo, Hiroshi Mitoma and Hitoshi Aizawa

    Citation: BMC Neurology 2020 20:161

    Content type: Research article

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  8. Early neurological deterioration (END) is common in acute ischemic stroke (IS). However, the underlying mechanisms for END are unclear. The aim of this study was to evaluate the associations of 16 variants in ...

    Authors: Xingyang Yi, Qiang Zhou, Yongyin Zhang, Ju Zhou and Jing Lin

    Citation: BMC Neurology 2020 20:159

    Content type: Research article

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  9. Fingolimod (Gilenya®), a first-in-class sphingosine-1-phosphate receptor modulator is approved for the treatment of relapsing-remitting multiple sclerosis. Fingolimod-induced selective immunosuppression leads ...

    Authors: Tobias Wienemann, Ann-Kristin Müller, Colin MacKenzie, Carina Bielor, Vivien Weyers, Orhan Aktas, Hans-Peter Hartung and David Kremer

    Citation: BMC Neurology 2020 20:158

    Content type: Case report

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  10. The “hot cross bun” (HCB) sign, a cruciform hyperintensity in the pons on magnetic resonance imaging (MRI), has gradually been identified as a typical finding in multiple system atrophy, cerebellar-type (MSA-C...

    Authors: Atsuhiko Sugiyama, Hajime Yokota, Yoshitaka Yamanaka, Hiroki Mukai, Tatsuya Yamamoto, Shigeki Hirano, Kyosuke Koide, Shoichi Ito and Satoshi Kuwabara

    Citation: BMC Neurology 2020 20:157

    Content type: Research article

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  12. To investigate the genetic and environmental factors responsible for phenotype variability in a family carrying a novel CACNA1A missense mutation. Mutations in the CACNA1A gene were identified as responsible for ...

    Authors: Rosaria Nardello, Giorgia Plicato, Giuseppe Donato Mangano, Elena Gennaro, Salvatore Mangano, Filippo Brighina, Vincenzo Raieli and Antonina Fontana

    Citation: BMC Neurology 2020 20:155

    Content type: Case report

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  13. Dysphagia is common after stroke. Patients with dysphagia have a higher risk of stroke-associated pneumonia (SAP) and poor outcomes. Early detection of dysphagia is necessary to identify and manage patients at...

    Authors: Zhu-Yun Liu, Xiao-Pei Zhang, Miao-Miao Mo, Ri-Chun Ye, Cai-Xia Hu, Min-Qing Jiang and Man-Qiu Lin

    Citation: BMC Neurology 2020 20:154

    Content type: Research article

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  14. Parasellar meningioma is a common benign tumour in brain. Both surgery and radiosurgery are important treatment modalities for this tumour. The study was designed to investigate whether prior surgery would aff...

    Authors: Yan-jia Hu, Yue-bing Xie, Li-feng Zhang, Chang Ding and Jing Chen

    Citation: BMC Neurology 2020 20:153

    Content type: Research article

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  15. Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analys...

    Authors: V. Arnao, A. Cinturino, S. Mastrilli, C. Buttà, C. Maida, A. Tuttolomondo, P. Aridon and M. D’Amelio

    Citation: BMC Neurology 2020 20:152

    Content type: Research article

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  16. Intracranial hypotension is a disorder characterized by low cerebrospinal fluid (CSF) pressure typically caused by loss of CSF. Although some mechanisms account for the CSF leakage have been elucidated, spinal...

    Authors: Chihiro Akiba, Hideki Bandai, Yoshitaka Ito, Tsuyoshi Maeda, Keisuke Yamaguchi, Madoka Nakajima and Masakazu Miyajima

    Citation: BMC Neurology 2020 20:151

    Content type: Case report

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  17. Infratentorial craniotomy patients have a high incidence of postoperative nausea and vomiting (PONV). Enhanced Recovery After Surgery (ERAS) protocols have been shown in multiple surgical disciplines to improv...

    Authors: Dan Lu, Yuan Wang, Tianzhi Zhao, Bolin Liu, Lin Ye, Lanfu Zhao, Binfang Zhao, Mingjuan Li, Lin Ma, Zhengmin Li, Jiangtao Niu, Wenhai Lv, Yufu Zhang, Tao Zheng, Yafei Xue, Lei Chen…

    Citation: BMC Neurology 2020 20:150

    Content type: Research article

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  18. Cavernous hemangioma of the orbit is a benign tumor mostly located behind the eye globe, but it rarely spread into the brain, which is called cerebral cavernous malformation as well, the lesion in the brain is...

    Authors: Xingping Qin, Farhana Akter, Lingxia Qin, Qiurong Xie, Yanfei Li, Hongkuan Yang, Xin Li, Guo Zhang, Songlin Wu and Renzhong Liu

    Citation: BMC Neurology 2020 20:149

    Content type: Case report

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  19. Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia. Studies on MCI progression are important for Alzheimer’s disease (AD) prevention. 18F fluoro-deoxy-glucose positron e...

    Authors: Lirong Teng, Yongchao Li, Yu Zhao, Tao Hu, Zhe Zhang, Zhijun Yao and Bin Hu

    Citation: BMC Neurology 2020 20:148

    Content type: Research article

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  20. Cerebrovascular disease (CVD) survivors are at a high risk of recurrent stroke. Although it is thought that survivors with higher risk of stroke respond better to stroke onset, to date, no study has been able ...

    Authors: Shengde Li, Li-Ying Cui, Craig Anderson, Chunpeng Gao, Chengdong Yu, Guangliang Shan, Longde Wang and Bin Peng

    Citation: BMC Neurology 2020 20:147

    Content type: Research article

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  21. Parkinson disease (PD) is a debilitating and chronic neurodegenerative disease resulting in ambulation difficulties. Natural walking activity often declines early in disease progression despite the relative st...

    Authors: Kerri S. Rawson, James T. Cavanaugh, Cristina Colon-Semenza, Tami DeAngelis, Ryan P. Duncan, Daniel Fulford, Michael P. LaValley, Pietro Mazzoni, Timothy Nordahl, Lisa M. Quintiliani, Marie Saint-Hilaire, Cathi A. Thomas, Gammon M. Earhart and Terry D. Ellis

    Citation: BMC Neurology 2020 20:146

    Content type: Study protocol

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  22. Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a “premutation (PM)” in the fragile X mental retardation 1 (FMR1) gene. Here we report a...

    Authors: Cuiping Zhao, Yiming Liu, Yihua Wang, Hongyan Li, Bin Zhang, Yaoxian Yue and Jianyuan Zhang

    Citation: BMC Neurology 2020 20:145

    Content type: Case report

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  23. Vagal nerve stimulation (VNS) can be an effective therapy for patients with epilepsy refractory to anti-epileptic drugs or intracranial surgery. While generally well tolerated, it has been associated with lary...

    Authors: James B. Nichols, Abigail P. McCallum, Nicolas K. Khattar, George Z. Wei, Rakesh Gopinathannair, Haring J. W. Nauta and Joseph S. Neimat

    Citation: BMC Neurology 2020 20:144

    Content type: Case report

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  24. This meta-analysis was designed to investigate the long-term efficacy and safety between cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF) in treating cervical disc degenerati...

    Authors: Yijian Zhang, Nanning Lv, Fan He, Bin Pi, Hao Liu, Angela Carley Chen, Huilin Yang, Mingming Liu and Xuesong Zhu

    Citation: BMC Neurology 2020 20:143

    Content type: Research article

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  26. Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal...

    Authors: James J. M. Loan, Michael T. C. Poon, Steven Tominey, Ncedile Mankahla, Graeme Meintjes and A. Graham Fieggen

    Citation: BMC Neurology 2020 20:141

    Content type: Research article

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  27. Presently, for patients presenting with suspected Normal Pressure Hydrocephalus (NPH) who undergo temporary drainage of cerebrospinal fluid (CSF) there is no defined model to differentiate chance improvement f...

    Authors: Alexander Davis, Sevil Yasar, Iris Emerman, Seema Gulyani, Kristina Khingelova, Aruna Rao, Lacie Manthripragada, Mark Luciano and Abhay Moghekar

    Citation: BMC Neurology 2020 20:140

    Content type: Research article

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  28. Endovascular therapy is widely used in acute large vessel occlusion. This study investigated whether imaging of lateral lenticulostriate arteries (LSAs) before thrombectomy would potentially be helpful for pre...

    Authors: Feifeng Liu, Chen Chen, Lan Hong, Hao Shen, Wenjie Cao, Qiang Dong, Xinyi Yang, Mengruo Guo, Ying Li, Yaping Xiao, Xin Cheng and Gang Li

    Citation: BMC Neurology 2020 20:139

    Content type: Research article

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  29. Fragile X syndrome (FXS) is the most frequent cause of inherited intellectual disability and the most commonly identified monogenic cause of autism. Recent studies have shown that long-term pathological conseq...

    Authors: Anke Van Dijck, Susana Barbosa, Patricia Bermudez-Martin, Olfa Khalfallah, Cyprien Gilet, Emanuela Martinuzzi, Ellen Elinck, R. Frank Kooy, Nicolas Glaichenhaus and Laetitia Davidovic

    Citation: BMC Neurology 2020 20:138

    Content type: Research article

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  30. Executive control dysfunction is observed in a sizable number of patients with temporal lobe epilepsy (TLE). Neural oscillations in the theta band are increasingly recognized as having a crucial role in execut...

    Authors: Yanping Ren, Liping Pan, Xueyun Du, Yuying Hou, Xun Li and Yijun Song

    Citation: BMC Neurology 2020 20:137

    Content type: Research article

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  32. Following acute ischemic stroke (AIS), approximately half of patients do not achieve recanalization after intravenous administration of tissue plasminogen activator (rt-PA). Thrombolysis resistance is a possib...

    Authors: Ye Li, Heying Wang, Lili Zhao, Yating Jian, Meijuan Dang, Yu Jiang, Yiheng Zhang, Lei Zhang, Huqing Wang, Ru Zhang, Mingxia Chen and Guilian Zhang

    Citation: BMC Neurology 2020 20:135

    Content type: Case report

    Published on:

  33. For acute ischemic stroke (AIS) patient receiving mechanical thrombectomy (MT), renal dysfunction was an independent risk factor of contrast-induced nephropathy which may affect clinical outcomes. However, the...

    Authors: Xiding Pan, Feng Zhou, Rui Shen, Yubing Zhu, Hisatomi Arima, Jie Yang and Junshan Zhou

    Citation: BMC Neurology 2020 20:134

    Content type: Research article

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  34. Cerebral palsy (CP) causes motor, cognitive and sensory impairment at different extents. Many recent rehabilitation developments (therapies) have focused solely on the upper extremities (UE), although the lowe...

    Authors: R. Araneda, S. V. Sizonenko, C. J. Newman, M. Dinomais, G. Le Gal, E. Nowak, A. Guzzetta, I. Riquelme, S. Brochard and Y. Bleyenheuft

    Citation: BMC Neurology 2020 20:133

    Content type: Study protocol

    Published on:

  35. RLS is known as one of the most common movement disorders during pregnancy, which is most aggravated in the third trimester of pregnancy and can affect up to one-third of pregnant women. This study intends to ...

    Authors: Niloofar Darvishi, Alireza Daneshkhah, Behnam Khaledi-Paveh, Aliakbar Vaisi-Raygani, Masoud Mohammadi, Nader Salari, Fateme Darvishi, Alireza Abdi and Rostam Jalali

    Citation: BMC Neurology 2020 20:132

    Content type: Research article

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  36. Cavernous malformations are rare cerebral pseudo-vascular lesions with annualized bleeding rates of 0.5–3% in most studies. Of the various explored risk factors for bleeding to date, only prior hemorrhage has ...

    Authors: Benjamin R. Hartley, Corinne Birnbaum and Caitlin E. Hoffman

    Citation: BMC Neurology 2020 20:131

    Content type: Case report

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  37. We imaged the corticospinal tract (CST) and corticoreticular pathway (CRP) using diffusion tensor tractography (DTT) to evaluate the cause of muscle weakness in a patient who was exposed to high-voltage electr...

    Authors: Mathieu Boudier-Revéret, Ming-Yen Hsiao, Shaw-Gang Shyu and Min Cheol Chang

    Citation: BMC Neurology 2020 20:130

    Content type: Case report

    Published on:

  39. Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular and cerebrovascular diseases. The C677T 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism increases homocysteine (HCY) levels. ...

    Authors: Xiaoxia Du, Lin Xiao, Rong Sun, Kunpeng Li, Lin Liang, Luping Song and Zhizhong Liu

    Citation: BMC Neurology 2020 20:128

    Content type: Research article

    Published on:

  40. The modified Rankin Scale (mRS) is a key global outcome measure after stroke internationally. The latest English version of the simplified modified Rankin scale questionnaire (smRSq)(2011) is a reliable and va...

    Authors: Junliang Yuan, Yunxiao Wang, Wenli Hu and Askiel Bruno

    Citation: BMC Neurology 2020 20:127

    Content type: Research article

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  41. IncobotulinumtoxinA (Xeomin®) is a botulinum neurotoxin type A with established efficacy in the treatment of upper-limb spasticity in adults. This retrospective case series in a university hospital setting aim...

    Authors: Angel León-Valenzuela, Juan Sánchez Palacios and Rogelio del Pino Algarrada

    Citation: BMC Neurology 2020 20:126

    Content type: Research article

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  42. Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative condition characterized by the loss of neurons and the presence of eosinophilic nuclear inclusions in the central and peripheral nervo...

    Authors: Mingming Li, Kai Li, Xin Li, Yun Tian, Lu Shen, Guode Wu, Zaiqiang Zhang and Weian Chen

    Citation: BMC Neurology 2020 20:125

    Content type: Case report

    Published on:

  44. A new type of epileptogenic tumor, the polymorphous low-grade neuroepithelial tumor of the young (PLNTY) was firstly reported by Jason T. Huse et al. at 2016. After that, only 1 case of PLNTY was reported by a...

    Authors: Yingqian Chen, Tian Tian, Xinwen Guo, Fenfen Zhang, Miao Fan, Huawei Jin and Dawei Liu

    Citation: BMC Neurology 2020 20:123

    Content type: Case report

    Published on:

  45. Reversible splenial lesion syndrome (RESLES) is known to cause severe psychiatric symptoms but is also a very rare clinical disease in which the specific aetiology is unknown. According to current reports, the...

    Authors: Song Hu, Xinyue Hou, Shuhao Liu, Chunxiao Fei, Lingyan Zhou, Ang Xing, Junqing Zhang, Chunming Yong and Xiaomeng Wang

    Citation: BMC Neurology 2020 20:122

    Content type: Case report

    Published on:

  46. Spinal dysraphism with a hamartomatous growth (appendix) of the spinal cord is better known as herniated spinal cord. There are many arguments in favour of considering it a developmental defect. From this poin...

    Authors: Ronald H. M. A. Bartels, J. Andre Grotenhuis, Alexander P. A. Stegmann and Han Brunner

    Citation: BMC Neurology 2020 20:121

    Content type: Case report

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  48. This systematic review and meta-analysis aimed to synthesize the latest evidence on the efficacy and safety of tranexamic acid (TXA) on traumatic brain injury (TBI).

    Authors: Julius July and Raymond Pranata

    Citation: BMC Neurology 2020 20:119

    Content type: Research article

    Published on:

  49. Acute hyperammonemia without signs of common causes in the elderly might be challenging to identify. We report the oldest case known to date of a female patient with late onset ornithine carbamyltransferase de...

    Authors: Justus Marquetand, Peter Freisinger, Tobias Lindig, Sebastian Euler, Michael Gasser and Dietrich Overkamp

    Citation: BMC Neurology 2020 20:118

    Content type: Case report

    Published on:

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