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  1. Content type: Research article

    Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed...

    Authors: Shaheen Ahmed, Mark Plazier, Jan Ost, Gaetane Stassijns, Steven Deleye, Sarah Ceyssens, Patrick Dupont, Sigrid Stroobants, Steven Staelens, Dirk De Ridder and Sven Vanneste

    Citation: BMC Neurology 2018 18:191

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  2. Content type: Case report

    Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic an...

    Authors: Tatsuya Ueno, Yukihiro Hasegawa, Rie Hagiwara, Tomoya Kon, Jin-ichi Nunomura and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:189

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  3. Content type: Research article

    Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

    Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

    Citation: BMC Neurology 2018 18:188

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  4. Content type: Study protocol

    Patients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of future cardiovascular events. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap ex...

    Authors: Thomas Toell, Christian Boehme, Lukas Mayer, Stefan Krebs, Clemens Lang, Karin Willeit, Barbara Prantl, Michael Knoflach, Gerhard Rumpold, Gudrun Schoenherr, Andrea Griesmacher, Peter Willeit, Julia Ferrari, Wilfried Lang, Stefan Kiechl and Johann Willeit

    Citation: BMC Neurology 2018 18:187

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  5. Content type: Research article

    Little is known about whether tolerability and adherence to treatment can be influenced by weather and temperature conditions. The objective of this study was to assess monthly and seasonal adherence to and sa...

    Authors: Spyros N. Deftereos, Evangelos Koutlas, Efrosini Koutsouraki, Athanassios Kyritsis, Panagiotis Papathanassopoulos, Nikolaos Fakas, Vaia Tsimourtou, Nikolaos Vlaikidis, Antonios Tavernarakis, Konstantinos Voumvourakis, Michalis Arvanitis, Dimitrios Sakellariou and Filippo DeLorenzo

    Citation: BMC Neurology 2018 18:186

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  6. Content type: Study protocol

    Parkinson’s disease (PD) is a chronic progressive disorder leading to increasing disability. While the symptoms and needs of patients in the early stages of their disease are well characterized, little informa...

    Authors: Monika Balzer-Geldsetzer, Joaquim Ferreira, Per Odin, Bastiaan R. Bloem, Wassilios G. Meissner, Stefan Lorenzl, Michael Wittenberg, Richard Dodel and Anette Schrag

    Citation: BMC Neurology 2018 18:185

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  7. Content type: Research article

    To determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

    Authors: Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun and Hao-kuang Wang

    Citation: BMC Neurology 2018 18:184

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  8. Content type: Research article

    Respiratory mechanics affects the effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP). Respiratory mechanics of the lung and the chest wall was not differentiated in previous studi...

    Authors: Han Chen, Jing Zhou, Yi-Qin Lin, Jian-Xin Zhou and Rong-Guo Yu

    Citation: BMC Neurology 2018 18:183

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  9. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition which comprises various neurological symptoms. This syndrome could be complicated by intracranial hemorrhage including subarachnoid...

    Authors: Dan Hu, Jing Xiong, Yunfei Zha and Zhaohui Zhang

    Citation: BMC Neurology 2018 18:182

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  10. Content type: Research article

    Physical activity (PA) is associated with lower risk of stroke. We tested the hypothesis that lack of pre-stroke PA is an independent predictor of poor outcome after first-ever ischemic stroke.

    Authors: Christian Urbanek, Viola Gokel, Anton Safer, Heiko Becher, Armin J. Grau, Florian Buggle and Frederick Palm

    Citation: BMC Neurology 2018 18:181

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  11. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical and neurological entity. There are varieties of comorbid conditions which are associated with PRES. Chronic obstructive pulmonary di...

    Authors: Sushil Khanal and Subhash Prasad Acharya

    Citation: BMC Neurology 2018 18:180

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  12. Content type: Research article

    Deep venous thrombosis (DVT) is a severe complication in longitudinally extensive transverse myelitis (LETM) patients. It may interfere with LETM treatment and delay the recovery of the spinal dysfunction. How...

    Authors: Tian Song, Xindi Li, Yonghong Liu and Xinghu Zhang

    Citation: BMC Neurology 2018 18:179

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  13. Content type: Case report

    Alemtuzumab has been demonstrated to reduce the risks of relapse and accumulation of sustained disability in Multiple Sclerosis (MS) patients compared to β-interferon. It acts against CD52, leading primarily t...

    Authors: A. G. Vakrakou, D. Tzanetakos, S. Valsami, E. Grigoriou, K. Psarra, J. Tzartos, M. Anagnostouli, E. Andreadou, M. E. Evangelopoulos, G. Koutsis, C. Chrysovitsanou, E. Gialafos, A. Dimitrakopoulos, L. Stefanis and C. Kilidireas

    Citation: BMC Neurology 2018 18:178

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  14. Content type: Research article

    Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.

    Authors: Chun-Sheng Yang, Qiu Xia Zhang, Sheng Hui Chang, Lin Jie Zhang, Li Min Li, Yuan Qi, Jing Wang, Zhi Hua Sun, Nannan Zhangning, Li Yang and Fu-Dong Shi

    Citation: BMC Neurology 2018 18:177

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  15. Content type: Case report

    Herpes simplex encephalitis is the most common type of sporadic encephalitis worldwide. Frank intracerebral hemorrhage complicating the disease course in herpes simplex encephalitis patients is rare, especiall...

    Authors: Yoon Hwan Byun, Eun Jin Ha, Sang-Bae Ko and Kyung Hyun Kim

    Citation: BMC Neurology 2018 18:176

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  16. Content type: Case report

    Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL, OMIM #611105) is a genetic disease of the central nervous system characterized by lower limb spasticity, cerebellar a...

    Authors: Ashraf Yahia, Liena Elsayed, Arwa Babai, Mustafa A. Salih, Sarah Misbah El-Sadig, Mutaz Amin, Mahmoud Koko, Rayan Abubakr, Razaz Idris, Shaimaa Omer M.A. Taha, Salah A. Elmalik, Alexis Brice, Ammar Eltahir Ahmed and Giovanni Stevanin

    Citation: BMC Neurology 2018 18:175

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  17. Content type: Case report

    DNA methyltransferase 1 (EC, encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and...

    Authors: Wenxia Zheng, Zhenxing Yan, Rongni He, Yaowei Huang, Aiqun Lin, Wei Huang, Yuying Su, Shaoyuan Li, Victor Wei Zhang and Huifang Xie

    Citation: BMC Neurology 2018 18:174

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  18. Content type: Case report

    Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome is a rare neurological condition. Its clinical characteristics include axial and limb muscle rigidity, myoclonus, painful spasms and hy...

    Authors: Aurélie Degeneffe, Marie Dagonnier, Alain D’hondt and Jose Antonio Elosegi

    Citation: BMC Neurology 2018 18:173

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  19. Content type: Research article

    The validation of international cognitive batteries in different multiple sclerosis (MS) populations is essential. Our objective was to obtain normative data for the Portuguese population of the Brief Internat...

    Authors: Cláudia Sousa, Mariana Rigueiro-Neves, Telma Miranda, Paulo Alegria, José Vale, Ana Margarida Passos, Dawn Langdon and Maria José Sá

    Citation: BMC Neurology 2018 18:172

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  20. Content type: Research article

    Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

    Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

    Citation: BMC Neurology 2018 18:171

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  21. Content type: Research article

    Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

    Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

    Citation: BMC Neurology 2018 18:147

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  22. Content type: Research article

    About 30% of stroke patients suffer from aphasia. As aphasia strongly affects daily life, most patients request a prediction of outcome of their language function. Prognostic models provide predictions of outc...

    Authors: Femke Nouwens, Evy G. Visch-Brink, Hanane El Hachioui, Hester F. Lingsma, Mieke W. M. E. van de Sandt-Koenderman, Diederik W. J. Dippel, Peter J. Koudstaal and Lonneke M. L. de Lau

    Citation: BMC Neurology 2018 18:170

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  23. Content type: Case report

    Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary...

    Authors: Xiangling Li, Zhengqi Lu and Yanqiang Wang

    Citation: BMC Neurology 2018 18:168

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  24. Content type: Research article

    Currently, it is challenging to detect the awareness of patients who suffer disorders of consciousness (DOC). Brain-computer interfaces (BCIs), which do not depend on the behavioral response of patients, may s...

    Authors: Qiuyou Xie, Jiahui Pan, Yan Chen, Yanbin He, Xiaoxiao Ni, Jiechun Zhang, Fei Wang, Yuanqing Li and Ronghao Yu

    Citation: BMC Neurology 2018 18:144

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  25. Content type: Research article

    Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hy...

    Authors: Tao Xue, Zhouqing Chen, Weiwei Lin, Jiayi Xu, Xuming Shen and Zhong Wang

    Citation: BMC Neurology 2018 18:167

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  26. Content type: Case report

    Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocul...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen, Patchalin Patputtipong and Tanyatuth Padungkiatsagul

    Citation: BMC Neurology 2018 18:165

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  27. Content type: Research article

    Studying the impact of demographic changes and progress in the management of stroke patients is necessary in order to organize care structures for the coming years. Consequently, we analyzed the prognostic tre...

    Authors: Emilio Rodríguez-Castro, Iria López-Dequit, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, José Manuel Pumar, Pablo Hervella, Esteban López-Arias, Andrés da Silva-Candal, Ana Estany, María Piñeiro-Lamas, Tomás Sobrino, Francisco Campos, Manuel Portela, Manuel Vázquez-Lima, José Castillo…

    Citation: BMC Neurology 2018 18:164

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  28. Content type: Research article

    Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely ...

    Authors: Lorenzo Pasquini, Jorge Llibre Guerra, Martin Prince, Kia-Chong Chua and A. Matthew Prina

    Citation: BMC Neurology 2018 18:163

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  29. Content type: Research article

    We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse even...

    Authors: G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli and Aileen Clarke

    Citation: BMC Neurology 2018 18:162

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  30. Content type: Case report

    Crohn’s disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been re...

    Authors: Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer and Brita Fritsch

    Citation: BMC Neurology 2018 18:161

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  31. Content type: Research article

    To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.

    Authors: Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö and Björn Hammar

    Citation: BMC Neurology 2018 18:160

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  32. Content type: Case report

    Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurologic...

    Authors: Tongtao Zhao, Gang Wang, Jiaman Dai, Yong Liu, Yi Wang and Shiying Li

    Citation: BMC Neurology 2018 18:159

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  33. Content type: Case report

    Catheter-related blood stream infection (CRBSI) is one of the most common intractable healthcare-associated infections because catheters can be easily contaminated by resistant bacteria, and is associated with...

    Authors: Nobuhiko Arai, Yutaka Mine, Hiroshi Kagami and Makoto Inaba

    Citation: BMC Neurology 2018 18:158

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  34. Content type: Case report

    The computed tomography (CT) finding of a pseudo-subarachnoid hemorrhage (SAH) may lead the treating physician into a diagnostic dilemma. We present a case of a pseudo-SAH in a patient with post-resuscitative ...

    Authors: Mohamad Syafeeq Faeez Md Noh and Anna Misyail Abdul Rashid

    Citation: BMC Neurology 2018 18:157

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  35. Content type: Research article

    Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical ...

    Authors: Angela S. M. Salinet, Ronney B. Panerai, Juliana Caldas, Ricardo C. Nogueira, Adriana B. Conforto, Manoel J. Texeira, Edson Bor-Seng-Shu and Thompson G. Robinson

    Citation: BMC Neurology 2018 18:156

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  36. Content type: Research article

    Peripheral diagnostics for Alzheimer’s disease (AD) continue to be developed. Diagnostics capable of detecting AD before the onset of symptoms are particularly desirable, and, given the fact that early detecti...

    Authors: Marwan N Sabbagh, Jiong Shi, Moonhee Lee, Lisa Arnold, Yazan Al-Hasan, Jennifer Heim and Patrick McGeer

    Citation: BMC Neurology 2018 18:155

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  37. Content type: Case report

    Autosomal recessive Myotonia congenita (Becker’s disease) is caused by mutations in the CLCN1 gene. The condition is characterized by muscle stiffness during sustained muscle contraction and variable degree of mu...

    Authors: Jing Miao, Xiao-jing Wei, Xue-mei Liu, Zhi-xia Kang, Yan-lu Gao and Xue-fan Yu

    Citation: BMC Neurology 2018 18:154

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  38. Content type: Research article

    Strategies are needed to improve adherence to the blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) level recommendations after stroke and transient ischemic attack (TIA). We investigated whe...

    Authors: Joachim Ögren, Anna-Lotta Irewall, Lars Söderström and Thomas Mooe

    Citation: BMC Neurology 2018 18:153

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  39. Content type: Research article

    The evaluation of children with cerebral palsy (CP) focuses on activity level measurement to examine the effect of health-care interventions on their physical functioning in the home, school, and community set...

    Authors: Soojung Chae, Eun-Young Park and Yoo-Im Choi

    Citation: BMC Neurology 2018 18:151

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  40. Content type: Case report

    Noonan syndrome-like disorder with loose anagen hair-2 (NSLH2) is an extremely rare disease caused by a heterozygous mutation in the PPP1CB gene on chromosome 2p23. The syndrome causes not only numerous dysmor...

    Authors: Chien-Heng Lin, Wei-De Lin, I-Ching Chou, Inn-Chi Lee, Hueng-Chuen Fan and Syuan-Yu Hong

    Citation: BMC Neurology 2018 18:150

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  41. Content type: Case report

    Only five patients have previously been reported to harbor mutations in the MT-TT gene encoding mitochondrial tRNA threonine. The m.15923A > G mutation has been found in three severely affected children. One of t...

    Authors: Mikko Kärppä, Laura Kytövuori, Markku Saari and Kari Majamaa

    Citation: BMC Neurology 2018 18:149

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  42. Content type: Research article

    Autonomic nervous system dysfunction, common in patients with Parkinson’s disease (PD), causes significant morbidity and it is correlated with poor quality of life. To assess frequency of urinary symptoms in p...

    Authors: Francesca Valentino, Tommaso Vincenzo Bartolotta, Giuseppe Cosentino, Sergio Mastrilli, Valentina Arnao, Paolo Aridon, Salvatore Scurria, Alice Pavone, Carlo Pavone and Marco D’Amelio

    Citation: BMC Neurology 2018 18:148

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  43. Content type: Research article

    Due to brain plasticity a transection of a median or ulnar nerve results in profound changes in the somatosensory areas in the brain. The permanent sensory deprivation after a peripheral nerve injury might inf...

    Authors: Pernilla Vikström, Anders Björkman, Ingela K. Carlsson, Anna-Karin Olsson and Birgitta Rosén

    Citation: BMC Neurology 2018 18:146

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  44. Content type: Case report

    The cardinal symptoms of auto-immune myasthenia gravis are fatigue and weakness. Endurance events such as marathon running would seem incompatible with this chronic disease. Many patients stop sport altogether...

    Authors: Simone Birnbaum, Tarek Sharshar, Bruno Eymard, Marie Theaudin, Pierre Portero and Jean-Yves Hogrel

    Citation: BMC Neurology 2018 18:145

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  45. Content type: Research article

    In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to char...

    Authors: Anthony Traboulsee, David K. B. Li, Mark Cascione, Juanzhi Fang, Fernando Dangond and Aaron Miller

    Citation: BMC Neurology 2018 18:143

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  46. Content type: Research article

    Patients with ischemic cerebrovascular diseases are more likely to suffer from intracranial aneurysms, and their surgical treatment has a growing controversy in this condition. The current case series was aime...

    Authors: Yangrui Zheng and Chen Wu

    Citation: BMC Neurology 2018 18:142

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  47. Content type: Research article

    Various outcome measures are used for the assessment of balance and mobility in patients with stroke. The purpose of the present study was to examine test-retest reliability, construct validity, and responsive...

    Authors: Ahmad H. Alghadir, Einas S. Al-Eisa, Shahnawaz Anwer and Bibhuti Sarkar

    Citation: BMC Neurology 2018 18:141

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