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  1. The evidence on the efficacy of adipose derived stem cells (ADSCs) in the treatment of stroke is controversial. Therefore, the aim of present systematic review and meta-analysis is to evaluate the efficacy of ...

    Authors: Mahmoud Yousefifard, Jebreil Shamseddin, Asrin Babahajian and Arash Sarveazad

    Citation: BMC Neurology 2020 20:294

    Content type: Research article

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  2. Atherosclerosis of the internal carotid artery (ICA) is an important cause of ischemic stroke. Artery-to-artery embolism is the major stroke mechanism in patients with atherosclerotic carotid disease. This stu...

    Authors: Ho Geol Woo, Sung Hyuk Heo, Eui Jong Kim, Dae-il Chang, Tae Jin Song and Bum Joon Kim

    Citation: BMC Neurology 2020 20:288

    Content type: Research article

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  3. The blood-brain barrier has been a hindrance to developing blood-based diagnostic tests for dementias, as it limits the appearance of brain biomarkers in the blood. Our aim was to see if the natural opening of...

    Authors: Dennis W. Choi, Tae Song Kim, Young Soo Kim and Dong Jin Kim

    Citation: BMC Neurology 2020 20:293

    Content type: Research article

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  4. The diagnosis of Parkinson’s Disease (PD) remains a challenge and is currently based on the assessment of clinical symptoms. PD is also a heterogeneous disease with great variability in symptoms, disease cours...

    Authors: A. F. Wolters, M. Heijmans, S. Michielse, A. F. G. Leentjens, A. A. Postma, J. F. A. Jansen, D. Ivanov, A. A. Duits, Y. Temel and M. L. Kuijf

    Citation: BMC Neurology 2020 20:292

    Content type: Study protocol

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  5. Stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS) is an autosomal recessive disorder caused by defects in the ADP-Ribosylhydrolase Like 2 (ADPRHL2; OMIM: 618170) gene. ...

    Authors: Hajar Aryan, Ehsan Razmara, Dariush Farhud, Marjan Zarif-Yeganeh, Shaghayegh Zokaei, Seyed Abbas Hassani, Mahmoud Reza Ashrafi, Masoud Garshasbi and Ali Reza Tavasoli

    Citation: BMC Neurology 2020 20:291

    Content type: Case report

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  6. Spastic paraplegia type 30 (SPG30) caused by KIF1A mutations was first reported in 2011 and was initially considered a very rare autosomal recessive (AR) form. In the last years, thanks to the development of mass...

    Authors: G. E. Rudenskaya, V. A. Kadnikova, O. P. Ryzhkova, L. A. Bessonova, E. L. Dadali, D. S. Guseva, T. V. Markova, D. N. Khmelkova and A. V. Polyakov

    Citation: BMC Neurology 2020 20:290

    Content type: Research article

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  7. To evaluate the medium-and long-term effect of intravascular interventional therapy for symptomatic severe basilar artery stenosis supported by multimodal imaging.

    Authors: Yuanzhi Li, Zhenfa Li, Ligang Song, Weimin Xie, Xianghao Gong, Dongliang He and Xin Zhang

    Citation: BMC Neurology 2020 20:289

    Content type: Research article

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  8. Surgical treatment of anterior communicating artery (Acom) aneurysm is challenging due to anatomic complexity. We aimed to describe our experiences with endovascular treatment (EVT) of Acom aneurysms, and to ev.....

    Authors: Chang Ki Jang, Joonho Chung, Jae Whan Lee, Seung Kon Huh, Nak-Hoon Son and Keun Young Park

    Citation: BMC Neurology 2020 20:287

    Content type: Research article

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  9. Central sensitization is thought to be an important contributing factor in many chronic pain disorders. The Central Sensitization Inventory (CSI) is a patient-reported measure frequently used to assess symptom...

    Authors: Saurab Sharma, Jyoti Jha, Anupa Pathak and Randy Neblett

    Citation: BMC Neurology 2020 20:286

    Content type: Research article

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  10. Patients with vascular Ehlers-Danlos syndrome (EDS) occasionally suffer from arterial dissection. Eagle syndrome, which is caused by an elongated styloid process and also causes arterial dissection, is difficu...

    Authors: Hajime Ikenouchi, Masahito Takagi, Ayako Nishimura, Eriko Yamaguchi, Junpei Koge, Kozue Saito, Kazunori Toyoda and Masatoshi Koga

    Citation: BMC Neurology 2020 20:285

    Content type: Case report

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  11. Compared with embolic occlusions, intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusions (LVOs) often require rescue treatment following mechanical thrombectomy (MT). Herein, we hypothesi...

    Authors: Yong-Won Kim, Sung-Il Sohn, Joonsang Yoo, Jeong-Ho Hong, Chang-Hyun Kim, Dong-Hun Kang, Yong-Sun Kim, Seong-Joon Lee, Ji Man Hong, Jin Wook Choi, Yang-Ha Hwang and Jin Soo Lee

    Citation: BMC Neurology 2020 20:284

    Content type: Research article

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  12. Although stent retriever (SR) is recommended as a frontline device of endovascular treatment (EVT) for embolic large artery occlusion causing acute ischemic stroke, contact aspiration (CA) device showed simila...

    Authors: Joonsang Yoo, Seong-Joon Lee, Jeong-Ho Hong, Yong-Won Kim, Ji Man Hong, Chang-Hyun Kim, Dong-Hun Kang, Jin Wook Choi, Yong-Sun Kim, Sung-Il Sohn, Yang-Ha Hwang and Jin Soo Lee

    Citation: BMC Neurology 2020 20:283

    Content type: Research article

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  13. Nonadherence to disease-modifying drugs (DMDs) for multiple sclerosis (MS) is associated with poorer clinical outcomes, including higher rates of relapse and disease progression, and higher medical resource us...

    Authors: Jacqueline A. Nicholas, Natalie C. Edwards, Roger A. Edwards, Anna Dellarole, Megan Grosso and Amy L. Phillips

    Citation: BMC Neurology 2020 20:281

    Content type: Research article

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  14. Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability and survival rates; however, to be effective, it must be given within 4.5 h of onset. Moreover, thromboly...

    Authors: Jun Ni, Huisheng Chen, Guofang Chen, Yong Ji, Fei Yi, Zhuobo Zhang, Yi Yang, Jin Wu, Xueli Cai, Bei Shao, Jianfeng Wang, Yafang Liu, Deqin Geng, Xinhui Qu, Xiaohong Li, Yan Wei…

    Citation: BMC Neurology 2020 20:282

    Content type: Research article

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  16. Balanced Steady State Free Precession (b-SSFP) sequences and the newly developed Fast-Spin-Echo (FSE)-sequences enable an optimized visualization of neurovascular compression (NVC) in patients with trigeminal ...

    Authors: Sebastian Müller, Eya Khadhraoui, Ali Khanafer, Marios Psychogios, Veit Rohde and Levent Tanrikulu

    Citation: BMC Neurology 2020 20:279

    Content type: Research article

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  17. Variants in the SLC25A1 gene are associated with a severe neurometabolic disease, D-2- and L-2-hydroxyglutaric aciduria (D/L-2-HGA). A report in 2014 presented the first account of congenital myasthenic syndrome ...

    Authors: Wenhui Li, Min Zhang, Linmei Zhang, Yiyun Shi, Lei Zhao, Bingbing Wu, Xihua Li and Shuizhen Zhou

    Citation: BMC Neurology 2020 20:278

    Content type: Case report

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  18. Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in D...

    Authors: Jeong-Yoon Lee, Soo Bin Park, Mina Lee, Hyunjin Ju, Kayeong Im and Kyum-Yil Kwon

    Citation: BMC Neurology 2020 20:277

    Content type: Research article

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  19. There is growing evidence for proprioceptive dysfunction in patients with Parkinson’s disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase o...

    Authors: Manuel Peterka, Thorsten Odorfer, Michael Schwab, Jens Volkmann and Daniel Zeller

    Citation: BMC Neurology 2020 20:276

    Content type: Research article

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  20. Headache and Attention Deficit Hyperactivity Disorder (ADHD) are two relatively common, neuropsychiatric conditions seen in children. Recent studies have shown an association between these two disorders, which...

    Authors: Udena Ruwindu Attygalle, Gemunu Hewawitharana and Champa Jayalakshmie Wijesinghe

    Citation: BMC Neurology 2020 20:275

    Content type: Research article

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  21. Real-world data on sufficient/insufficient response, and predictors of insufficient response, to acute treatments for migraine are limited in Japan. This study aimed to identify factors associated with insuffi...

    Authors: Koichi Hirata, Kaname Ueda, Wenyu Ye, Yongin Kim, Mika Komori, James Jackson, Sarah Cotton, Narayan Rajan and Tamas Treuer

    Citation: BMC Neurology 2020 20:274

    Content type: Research article

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  22. Restoring community walking remains a highly valued goal for persons recovering from traumatic incomplete spinal cord injury (SCI). Recently, studies report that brief episodes of low-oxygen breathing (acute i...

    Authors: Avantika Naidu, Denise M. Peters, Andrew Q. Tan, Stella Barth, Andrea Crane, Angela Link, Swapna Balakrishnan, Heather B. Hayes, Chloe Slocum, Ross D. Zafonte and Randy D. Trumbower

    Citation: BMC Neurology 2020 20:273

    Content type: Study protocol

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  23. Cerebral-cardiac syndrome, newly developed cardiac damage manifestations subsequent to cerebral injuries, is a common complication of stroke and leads to increased morbidity and mortality. The current study is...

    Authors: Haijuan Lian, Xiaomeng Xu, Xuhui Shen, Jinhua Chen, Dandan Mao, Yan Zhao and Meiqi Yao

    Citation: BMC Neurology 2020 20:272

    Content type: Research article

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  24. Cerebral vasospasm still results in high morbidity and mortality rates in patients after aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to establish a protocol for the management of vasosp...

    Authors: Chun-Ting Chen, Ching-Chang Chen, Alvin Yi-Chou Wang, Yi-Ming Wu, Shy-Chyi Chin, Po-Chuan Hsieh, Mun-Chun Yeap, Shih-Yuan Hsu and Ya-Jui Lin

    Citation: BMC Neurology 2020 20:271

    Content type: Research article

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  25. Stroke mimics account for up to one-third of acute stroke admissions and are a heterogeneous entity which pose diagnostic challenges. Diagnosing such patients is however crucial to avoid delays in treatment an...

    Authors: Sarah Shali Matuja, Khuzeima Khanbhai, Karim M. Mahawish and Patricia Munseri

    Citation: BMC Neurology 2020 20:270

    Content type: Research article

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  26. Acute ischemic stroke is a time-sensitive emergency where accurate diagnosis is required promptly. Due to time pressures, stroke mimics who present with similar signs and symptoms as acute ischemic stroke, pos...

    Authors: Tian Ming Tu, Guan Zhong Tan, Seyed Ehsan Saffari, Chee Keong Wee, David Jeremiah Ming Siang Chee, Camlyn Tan and Hoon Chin Lim

    Citation: BMC Neurology 2020 20:269

    Content type: Research article

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  27. The ultrasound based non-invasive ICP measurement method has been recently validated. Correlation of symptoms and signs of intracranial hypertension with actual ICP measurements in patients with large intracra...

    Authors: Jenny C. Kienzler, Rolandas Zakelis, Serge Marbacher, Sabrina Bäbler, Lucia Schwyzer, Elke Remonda and Javier Fandino

    Citation: BMC Neurology 2020 20:268

    Content type: Research article

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  29. Remote ischemic conditioning during cerebral ischemia (remote ischemic perconditioning, RIPerC) refers to the application of several cycles of brief ischemia and reperfusion (I/R) commonly to a limb, and it re...

    Authors: Francisco Purroy, Cristina García, Gerard Mauri, Cristina Pereira, Coral Torres, Daniel Vazquez-Justes, Mikel Vicente-Pascual, Ana Vena and Gloria Arque

    Citation: BMC Neurology 2020 20:266

    Content type: Research article

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  31. The level of function of instrumental activities of daily living (IADL) is crucial for a person’s autonomy. A clear understanding of the nature of IADL and its limitations in people with mild cognitive impairm...

    Authors: Marina Bruderer-Hofstetter, Sietske A. M. Sikkes, Thomas Münzer and Karin Niedermann

    Citation: BMC Neurology 2020 20:264

    Content type: Research article

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  32. Level of dependency after a stroke is important for long-term outcome in several aspects, but less is known about important predictors for outcome depending on functional dependency. The aim of the current stu...

    Authors: Emma Westerlind, Daniel Hörsell and Hanna C. Persson

    Citation: BMC Neurology 2020 20:263

    Content type: Research article

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  33. In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...

    Authors: Xue Ling Liu, Li Qin Yang, Feng Tao Liu, Pu-Yeh Wu, Yong Zhang, Han Zhuang, Yong Hong Shi, Jian Wang, Dao Ying Geng and Yu Xin Li

    Citation: BMC Neurology 2020 20:262

    Content type: Research article

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  34. Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs.

    Authors: Marianna Delussi, Eleonora Vecchio, Giuseppe Libro, Silvia Quitadamo and Marina de Tommaso

    Citation: BMC Neurology 2020 20:256

    Content type: Research article

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  35. Psychopathology and personality traits may influence the course of autoimmune disorders. With this prospective longitudinal cohort study, we aimed to assess personality, stress and depression in myasthenia pat...

    Authors: Anca Bogdan, Carolina Barnett, Abdulrahman Ali, Mohammed AlQwaifly, Alon Abraham, Shabber Mannan, Eduardo Ng and Vera Bril

    Citation: BMC Neurology 2020 20:261

    Content type: Research article

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  36. Delayed cerebral ischemia is one of the leading causes of death and disability in patients with subarachnoid hemorrhage (SAH). Transluminal balloon angioplasty (TBA) is a therapeutic option for vasospasms affe...

    Authors: Ioannis Tsogkas, Vesna Malinova, Katharina Schregel, Dorothee Mielke, Daniel Behme, Veit Rohde, Michael Knauth and Marios-Nikos Psychogios

    Citation: BMC Neurology 2020 20:260

    Content type: Research article

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  38. Leukodystrophies are familial heterogeneous disorders primarily affecting the white matter, which are defined as hypomyelinating or demyelinating based on disease severity as assessed at MRI. Recently, a group...

    Authors: Rosa Campopiano, Rosangela Ferese, Stefania Zampatti, Emiliano Giardina, Francesca Biagioni, Claudio Colonnese, Diego Centonze, Marianna Storto, Fabio Buttari, Edoardo Fraviga, Vania Broccoli, Mirco Fanelli, Francesco Fornai and Stefano Gambardella

    Citation: BMC Neurology 2020 20:258

    Content type: Case report

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  39. Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and...

    Authors: Sang Hee Ha, Yeon-Jung Kim, Sung Hyuk Heo, Dae-il Chang and Bum Joon Kim

    Citation: BMC Neurology 2020 20:257

    Content type: Research article

    Published on:

  40. Even though recent research has achieved significant advancement in the development of therapeutic approaches for Wilson’s diseases (WD), the current treatment options available for WD are still limited, espec...

    Authors: Jing Zhang, Lulu Xiao and Wenming Yang

    Citation: BMC Neurology 2020 20:255

    Content type: Research article

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  41. Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs for upper limb are critically needed. Brain-Computer Interfaces (BCIs) which enable the modulation of Elect...

    Authors: Donatella Mattia, Floriana Pichiorri, Emma Colamarino, Marcella Masciullo, Giovanni Morone, Jlenia Toppi, Iolanda Pisotta, Federica Tamburella, Matteo Lorusso, Stefano Paolucci, Maria Puopolo, Febo Cincotti and Marco Molinari

    Citation: BMC Neurology 2020 20:254

    Content type: Study protocol

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  43. High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association...

    Authors: Pablo M. Lavados, Enrico Mazzon, Alexis Rojo, Alejandro M. Brunser and Verónica V. Olavarría

    Citation: BMC Neurology 2020 20:252

    Content type: Research article

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  44. The purpose of this study was to clarify the effect of asymmetric COW variants on carotid flow changes, and proposed an easy estimate of the representative carotid flow volume for accurate numerical simulation.

    Authors: Te-Chang Wu, Tai-Yuan Chen, Ching-Chung Ko, Jeon-Hor Chen and Ching-Po Lin

    Citation: BMC Neurology 2020 20:251

    Content type: Research article

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  45. Post-stroke depression (PSD) is a mood disorder characterized by depression and anhedonia caused by stroke. Metabolomics identified metabolites associated with PSD, but previous studies are based on gas chroma...

    Authors: Man Wang, Xianwei Gui, Lanxiang Wu, Sheng Tian, Hansen Wang, Liang Xie and Wei Wu

    Citation: BMC Neurology 2020 20:250

    Content type: Research article

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  46. Cerebral venous sinus thrombosis (CVST), a rare cause of cerebral infarction, is often unrecognized at initial presentation. We report the case of a patient with bilateral corpus callosum and corona radiata in...

    Authors: Rui Lan, Yun-zhi Ma, Xiao-ming Shen, Ji-tao Wu, Chun-qing Gu and Yong Zhang

    Citation: BMC Neurology 2020 20:249

    Content type: Case report

    Published on:

  47. COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of ...

    Authors: Shelli Farhadian, Laura R. Glick, Chantal B. F. Vogels, Jared Thomas, Jennifer Chiarella, Arnau Casanovas-Massana, Jing Zhou, Camila Odio, Pavithra Vijayakumar, Bertie Geng, John Fournier, Santos Bermejo, Joseph R. Fauver, Tara Alpert, Anne L. Wyllie, Cynthia Turcotte…

    Citation: BMC Neurology 2020 20:248

    Content type: Case report

    Published on:

  48. A unique patient with MELAS syndrome, who initially masqueraded as having acute encephalitis and was eventually diagnosed with MELAS syndrome harboring a mtDNA 14453G → A mutation, is described.

    Authors: Yuki Yokota, Makoto Hara, Takayoshi Akimoto, Tomotaka Mizoguchi, Yu-ichi Goto, Ichizo Nishino, Satoshi Kamei and Hideto Nakajima

    Citation: BMC Neurology 2020 20:247

    Content type: Case report

    Published on:

  49. KMT2B-related dystonia is a recently described form of childhood onset dystonia that may improve with deep brain stimulation. Prior reports have focused on neurologic features including prominent bulbar involveme...

    Authors: Andrew Ng, Serena Galosi, Lisa Salz, Terence Wong, Caitlin Schwager, Shivarajan Amudhavalli, Rose Gelineau-Morel, Shimul Chowdhury and Jennifer Friedman

    Citation: BMC Neurology 2020 20:246

    Content type: Case report

    Published on:

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