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  1. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controv...

    Authors: Petros Skapinakis, Eleni Bakola, Georgia Salanti, Glyn Lewis, Athanasios P Kyritsis and Venetsanos Mavreas
    Citation: BMC Neurology 2010 10:49
    Content type: Research article Published on:

  3. Data from different studies suggest a favourable association between pretreatment with statins or hypercholesterolemia and outcome after ischaemic stroke. We examined whether there were differences in in-hospi...

    Authors: Adrià Arboix, Luis García-Eroles, Montserrat Oliveres, Cecília Targa, Miquel Balcells and Joan Massons
    Citation: BMC Neurology 2010 10:47
    Content type: Research article Published on:

  5. Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that predominantly affects the optic nerves and the spinal cord, and is possibly mediated by an immune mechanism distinct from that of multip...

    Authors: Hideto Nakajima, Takafumi Hosokawa, Masakazu Sugino, Fumiharu Kimura, Jun Sugasawa, Toshiaki Hanafusa and Toshiyuki Takahashi
    Citation: BMC Neurology 2010 10:45
    Content type: Research article Published on:

  6. Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain....

    Authors: Kathy Lee, Pornpun Vivithanaporn, Reed A Siemieniuk, Hartmut B Krentz, Ferdinand Maingat, M John Gill and Christopher Power
    Citation: BMC Neurology 2010 10:44
    Content type: Research article Published on:

  7. Fatigue is one of the most commonly reported and debilitating symptoms of multiple sclerosis (MS); approximately two-thirds of people with MS consider it to be one of their three most troubling symptoms. It ma...

    Authors: Peter W Thomas, Sarah Thomas, Paula Kersten, Rosemary Jones, Alison Nock, Vicky Slingsby, Colin Green, Roger Baker, Kate Galvin and Charles Hillier
    Citation: BMC Neurology 2010 10:43
    Content type: Study protocol Published on:

  8. Despite worldwide recognition of the burden of dementia, no epidemiological data is yet available in Portugal. The objective of this study is to estimate the prevalence and describe the pattern of cognitive im...

    Authors: Belina Nunes, Ricardo D Silva, Vitor T Cruz, Jose M Roriz, Joana Pais and Maria C Silva
    Citation: BMC Neurology 2010 10:42
    Content type: Research article Published on:

  9. Genetic factors may play a role in susceptibility to spontaneous deep intracerebral hemorrhage (SDICH). Previous studies have shown that TNF-α gene variation was associated with risks of subarachnoid hemorrhage i...

    Authors: Yi-Chun Chen, Fen-Ju Hu, Phoebe Chen, Yih-Ru Wu, Hsiu-Chuan Wu, Sien-Tsong Chen, Guey-Jen Lee-Chen and Chiung-Mei Chen
    Citation: BMC Neurology 2010 10:41
    Content type: Research article Published on:

  10. Despite the cardiovascular etiology of stroke, exercise and risk factor modification programs akin to cardiac rehabilitation (CR) are not available. This study aimed to establish the feasibility of adapting a ...

    Authors: Ada Tang, Susan Marzolini, Paul Oh, William E McIlroy and Dina Brooks
    Citation: BMC Neurology 2010 10:40
    Content type: Research article Published on:

  11. PC plays an important role in early diagnosis of health disorders, particularly migraine, due to the financial impact of this disease for the society and its impact on patients' quality of life. The aim of the...

    Authors: Miguel J Láinez, Jesús Castillo, Manuel Domínguez, Gemma Palacios, Silvia Díaz and Javier Rejas
    Citation: BMC Neurology 2010 10:39
    Content type: Research article Published on:

  12. Fabry patients have symptoms and signs compatible with autonomic dysfunction. These symptoms and signs are considered to be due to impairment of the peripheral nervous system, but findings indicative of autono...

    Authors: Marieke Biegstraaten, Ivo N van Schaik, Wouter Wieling, Frits A Wijburg and Carla EM Hollak
    Citation: BMC Neurology 2010 10:38
    Content type: Research article Published on:

  13. Holmes tremor is a rare symptomatic movement disorder. Currently suggested pathophysiological mechanisms of the disease are mostly derived from stroke cases. Although rare, cerebral toxoplasmosis may strengthe...

    Authors: Alain Lekoubou, Rodrigue Njouoguep, Callixte Kuate and André Pascal Kengne
    Citation: BMC Neurology 2010 10:37
    Content type: Case report Published on:

  14. Animal models of focal cerebral ischemia are widely used in stroke research. The purpose of our study was to evaluate and compare the cerebral macro- and microvascular architecture of rats in two different mod...

    Authors: Alexander C Langheinrich, Mesut Yeniguen, Anne Ostendorf, Simone Marhoffer, Marian Kampschulte, Georg Bachmann, Erwin Stolz and Tibo Gerriets
    Citation: BMC Neurology 2010 10:36
    Content type: Research article Published on:

  15. Assessment of visual fixation is commonly used in the clinical examination of patients with disorders of consciousness. However, different international guidelines seem to disagree whether fixation is compatib...

    Authors: Marie-Aurélie Bruno, Audrey Vanhaudenhuyse, Caroline Schnakers, Mélanie Boly, Olivia Gosseries, Athena Demertzi, Steve Majerus, Gustave Moonen, Roland Hustinx and Steven Laureys
    Citation: BMC Neurology 2010 10:35
    Content type: Research article Published on:

  16. Spontaneous intracerebral hemorrhage (ICH) accounts for a high mortality and morbidity. Early prediction of outcome is crucial for optimized care and treatment decision. Copeptin, the C-terminal part of provas...

    Authors: Christian Zweifel, Mira Katan, Philipp Schuetz, Martin Siegemund, Nils G Morgenthaler, Adrian Merlo, Beat Mueller and Mirjam Christ-Crain
    Citation: BMC Neurology 2010 10:34
    Content type: Research article Published on:

  17. In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure. We evaluated the role of myocardial inflammation as a precipitati...

    Authors: Sophie Mavrogeni, Antigoni Papavasiliou, Kostas Spargias, Pantelis Constandoulakis, George Papadopoulos, Evangelos Karanasios, Dimitris Georgakopoulos, Genovefa Kolovou, Eftichia Demerouti, Spyridon Polymeros, Loukas Kaklamanis, Anastasios Magoutas, Evangelia Papadopoulou, Vyron Markussis and Dennis V Cokkinos
    Citation: BMC Neurology 2010 10:33
    Content type: Research article Published on:

  19. Lacunar syndrome not due to lacunar infarct is poorly characterised. This single centre, retrospective study was conducted to describe the clinical characteristics of patients with lacunar syndrome not due to ...

    Authors: Adrià Arboix, Joan Massons, Luis García-Eroles, Cecilia Targa, Emili Comes and Olga Parra
    Citation: BMC Neurology 2010 10:31
    Content type: Research article Published on:

  21. The c.2447G>A (p.R722H) mutation in the gene POLG1 of the catalytic subunit of human mitochondrial polymerase gamma has been previously found in a few occasions but its pathogenicity has remained uncertain. We se...

    Authors: Tuomas Komulainen, Reetta Hinttala, Mikko Kärppä, Leila Pajunen, Saara Finnilä, Hannu Tuominen, Heikki Rantala, Ilmo Hassinen, Kari Majamaa and Johanna Uusimaa
    Citation: BMC Neurology 2010 10:29
    Content type: Research article Published on:

  22. Multiple sclerosis (MS) currently requires long-term treatment with disease-modifying drugs, administered parenterally up to once daily. The need for regular self-injection can be a barrier to treatment for ma...

    Authors: Virginia Devonshire, Txomin Arbizu, Björn Borre, Michael Lang, Alessandra Lugaresi, Barry Singer, Elisabetta Verdun di Cantogno and Peter Cornelisse
    Citation: BMC Neurology 2010 10:28
    Content type: Research article Published on:

  23. The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concen...

    Authors: Gianluca Tamagno, Yahya Celik, Rafael Simó, Marcel Dihné, Kazumi Kimura, Giorgio Gelosa, Byung I Lee, Caroline Hommet and Giovanni Murialdo
    Citation: BMC Neurology 2010 10:27
    Content type: Research article Published on:

  24. Short and valid measures of the impact of a stroke on integration are required in health and social settings. The Subjective Index of Physical and Social Outcome (SIPSO) is one such measure. However, there are...

    Authors: Paula Kersten, Ann Ashburn, Steve George and Joseph Low
    Citation: BMC Neurology 2010 10:26
    Content type: Research article Published on:

  25. Conflicting data exists regarding the effect of hemispheric lateralization on acute ischemic stroke outcome. Some of this variability may be related to heterogeneous study populations, particularly with respec...

    Authors: Albert J Yoo, Javier Romero, Reza Hakimelahi, Raul G Nogueira, James D Rabinov, Johnny C Pryor, R Gilberto González, Joshua A Hirsch and Pamela W Schaefer
    Citation: BMC Neurology 2010 10:25
    Content type: Research article Published on:

  26. The present investigation was designed to elucidate the use of dynamic contrast enhanced perfusion MR imaging (DCE pMRI) in characterizing hyperemia, including microvessel changes, and to examine whether DCE p...

    Authors: Haitao Lu, Jungong Zhao, Minghua Li, Yingsheng Cheng, Yongdong Li, Xiaofang You and Yuwu Zhao
    Citation: BMC Neurology 2010 10:24
    Content type: Research article Published on:

  27. Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast canc...

    Authors: Jeanne C Latourelle, Merete Dybdahl, Anita L Destefano, Richard H Myers and Timothy L Lash
    Citation: BMC Neurology 2010 10:23
    Content type: Research article Published on:

  28. In the setting of an acute stroke, anemia has the potential to worsen brain ischemia, however, the relationship between the entire range of hemoglobin to long-term outcome is not well understood.

    Authors: David Tanne, Noa Molshatzki, Oleg Merzeliak, Rakefet Tsabari, Maya Toashi and Yvonne Schwammenthal
    Citation: BMC Neurology 2010 10:22
    Content type: Research article Published on:

  29. Alexander disease (ALX) is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrilla...

    Authors: Michito Namekawa, Yoshihisa Takiyama, Junko Honda, Haruo Shimazaki, Kumi Sakoe and Imaharu Nakano
    Citation: BMC Neurology 2010 10:21
    Content type: Case report Published on:

  30. Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I.

    Authors: Roberto S Perez, Paul E Zollinger, Pieter U Dijkstra, Ilona L Thomassen-Hilgersom, Wouter W Zuurmond, Kitty CJ Rosenbrand and Jan H Geertzen
    Citation: BMC Neurology 2010 10:20
    Content type: Research article Published on:

  31. Patients suffering from intracerebral haemorrhage have a poor prognosis, especially if they are using antiplatelet therapy. Currently, no effective acute treatment option for intracerebral haemorrhage exists. ...

    Authors: Koen de Gans, Rob J de Haan, Charles B Majoie, Maria M Koopman, Anneke Brand, Marcel G Dijkgraaf, Marinus Vermeulen and Yvo B Roos
    Citation: BMC Neurology 2010 10:19
    Content type: Study protocol Published on:

  32. Endothelium-derived nitric oxide (NO) mediates the arterial dilation following a flow increase (i.e. flow-mediated dilation, FMD), easily assessed in the brachial artery. NO is also involved in cerebral hemody...

    Authors: Fabrizio Vernieri, Leo Moro, Claudia Altamura, Paola Palazzo, Raffaele Antonelli Incalzi, Paolo Maria Rossini and Claudio Pedone
    Citation: BMC Neurology 2010 10:18
    Content type: Research article Published on:

  33. Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder that can be an autosomal-dominant, autosomal-recessive, or X-linked disease. The most common autosomal-dominant form o...

    Authors: Mark Braschinsky, Riin Tamm, Christian Beetz, Elena Sachez-Ferrero, Elve Raukas, Siiri-Merike Lüüs, Katrin Gross-Paju, Catherine Boillot, Federico Canzian, Andres Metspalu and Sulev Haldre
    Citation: BMC Neurology 2010 10:17
    Content type: Research article Published on:

  34. Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the pare...

    Authors: Graciela Cárdenas, Roger Carrillo-Mezo, Helgi Jung, Edda Sciutto, Jose Luis Soto Hernandez and Agnès Fleury
    Citation: BMC Neurology 2010 10:16
    Content type: Case report Published on:

  35. Adherence to therapies is a primary determinant of treatment success, yet the World Health Organisation estimate that only 50% of patients who suffer from chronic diseases adhere to treatment recommendations. ...

    Authors: Ronan O'Carroll, Martin Dennis, Marie Johnston and Cathie Sudlow
    Citation: BMC Neurology 2010 10:15
    Content type: Study protocol Published on:

  36. Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that ...

    Authors: Teresa Liu-Ambrose, Janice J Eng, Lara A Boyd, Claudia Jacova, Jennifer C Davis, Stirling Bryan, Philip Lee, Penny Brasher and Ging-Yuek R Hsiung
    Citation: BMC Neurology 2010 10:14
    Content type: Study protocol Published on:

  37. The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients w...

    Authors: R Gilberto González, Reza Hakimelahi, Pamela W Schaefer, Luca Roccatagliata, A Gregory Sorensen and Aneesh B Singhal
    Citation: BMC Neurology 2010 10:13
    Content type: Research article Published on:

  38. Use of electronic media, i.e. mobile phones, computers, television, game consoles or listening to music, is very common, especially amongst adolescents. There is currently a debate about whether frequent use o...

    Authors: Astrid Milde-Busch, Rüdiger von Kries, Silke Thomas, Sabine Heinrich, Andreas Straube and Katja Radon
    Citation: BMC Neurology 2010 10:12
    Content type: Research article Published on:

  39. In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept - best left to philosophers. However, times are changing and the need to clinically assess conscio...

    Authors: Jodie R Gawryluk, Ryan CN D'Arcy, John F Connolly and Donald F Weaver
    Citation: BMC Neurology 2010 10:11
    Content type: Review Published on:

  40. Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondri...

    Authors: Richard G Boles, Mary R Lovett-Barr, Amy Preston, B UK Li and Kathleen Adams
    Citation: BMC Neurology 2010 10:10
    Content type: Research article Published on:

  41. In idiopathic Parkinson's disease (IPD) transcranial sonography (TCS) represents an alternative diagnostic method to verify clinical diagnosis. Although the phenomenon of an increased echogenicity of the Subst...

    Authors: Sabine Mehnert, Iris Reuter, Karsten Schepp, Peter Maaser, Erwin Stolz and Manfred Kaps
    Citation: BMC Neurology 2010 10:9
    Content type: Research article Published on:

  42. Postpoliomyelitis Syndrome (PPS) is a complex of late onset neuromuscular symptoms with new or increased muscle weakness and muscle fatigability as key symptoms. Main clinical complaints are severe fatigue, de...

    Authors: Fieke S Koopman, Anita Beelen, Karin H Gerrits, Gijs Bleijenberg, Tineke A Abma, Marianne de Visser and Frans Nollet
    Citation: BMC Neurology 2010 10:8
    Content type: Study protocol Published on:

  43. Migraine is a common disorder that is highly co-morbid with psychopathological conditions such as depression and anxiety. Despite the extensive research and availability of treatment, migraine remains under-re...

    Authors: Zainab Samaan, E Anne MacGregor, Dowson Andrew, Peter McGuffin and Anne Farmer
    Citation: BMC Neurology 2010 10:7
    Content type: Research article Published on:

  44. Previous epidemiologic studies have examined the association of smoking with amyotrophic lateral sclerosis (ALS) incidence, but their results have been inconsistent. Moreover, limited information exists on the...

    Authors: Alvaro Alonso, Giancarlo Logroscino, Susan S Jick and Miguel A Hernán
    Citation: BMC Neurology 2010 10:6
    Content type: Research article Published on:

  45. Surrogate pain models have been extensively tested in Normal Human Volunteers (NHV). There are few studies that examined pain models in chronic pain patients. Patients are likely to have altered pain mechanism...

    Authors: Remigiusz Lecybyl, Juan Acosta, Joydeep Ghoshdastidar, Kinga Stringfellow and Magdi Hanna
    Citation: BMC Neurology 2010 10:5
    Content type: Research article Published on:

  46. Congenital hemiplegia is the most common form of cerebral palsy (CP) accounting for 1 in 1300 live births. These children have limitations in capacity to use the impaired upper limb and bimanual coordination d...

    Authors: Roslyn Boyd, Leanne Sakzewski, Jenny Ziviani, David F Abbott, Radwa Badawy, Rose Gilmore, Kerry Provan, Jacques-Donald Tournier, Richard AL Macdonell and Graeme D Jackson
    Citation: BMC Neurology 2010 10:4
    Content type: Study protocol Published on:

  47. More than 60% of new strokes each year are "mild" in severity and this proportion is expected to rise in the years to come. Within our current health care system those with "mild" stroke are typically discharg...

    Authors: Annie Rochette, Nicol Korner-Bitensky, Duane Bishop, Robert Teasell, Carole White, Gina Bravo, Robert Côté, Jean Lachaine, Teri Green, Louise-Hélène Lebrun, Sylvain Lanthier, Moira Kapral and Sharon Wood-Dauphinee
    Citation: BMC Neurology 2010 10:3
    Content type: Study protocol Published on:

  50. Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.

    Authors: Magnus Gisslén, Jan Krut, Ulf Andreasson, Kaj Blennow, Paola Cinque, Bruce J Brew, Serena Spudich, Lars Hagberg, Lars Rosengren, Richard W Price and Henrik Zetterberg
    Citation: BMC Neurology 2009 9:63
    Content type: Research article Published on:
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