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An unusual case of the syndrome of cervical rib with subclavian artery thrombosis and cerebellar and cerebral infarctions
- Mirza Jusufovic†1Email author,
- Else Charlotte Sandset†1,
- Trine Haug Popperud†1,
- Steinar Solberg†2,
- Geir Ringstad†3 and
- Emilia Kerty†1, 4
© Jusufovic et al.; licensee BioMed Central Ltd. 2012
Received: 21 February 2012
Accepted: 25 June 2012
Published: 28 June 2012
Cerebellar and cerebral infarctions caused by the syndrome of cervical rib with thrombosis of subclavian artery are very unusual.
We report the case of a 49-year-old male patient with a right cervical rib compression leading to subclavian arterial thrombosis and both cerebellar and cerebral infarctions secondary to retrograde thromboembolisation. Follow-up imaging revealed partial resolution of the thrombosis after combined anti-coagulant and anti-platelet therapy. The cervical rib and first costa were surgically removed to prevent additional events.
Cervical rib vascular compression should be promptly diagnosed and treated in order to avoid further complications, including cerebrovascular ischemic events.
The presence of a cervical rib was already mentioned in the works of Galen in the second century A.D, and in 16th century by Vesalius . Arteriothromboembolic events due to cervical rib compression of subclavian artery are rare. The commonest source of cerebral thromboembolism is artery-to-artery embolism from heart or proximal circulation.
Symonds reported in 1927 two cases with an initial history of symptoms of right upper extremity claudication due to a right cervical rib, followed later by acute left hemiplegia . He concluded that pressure of cervical rib upon the right subclavian artery led to subclavian thrombosis with right upper extremity embolisation and finally to embolic occlusion into the right middle cerebral artery .
In more recent literature, the term thoracic outlet syndrome (TOS) was introduced by Peet in 1956 to put together upper limb symptoms arising from neurovascular compression in the interscalene triangle . TOS is classified into three categories according to neurovascular anatomy: arterial (subclavian artery, <1%), venous (subclavian vein, 4%–6%), and neurogenic (brachial plexus, 94%–97%).
Cerebral infarction or TIA caused by cervical rib-associated arterial compression is unusual and very few cases have been described [2, 4–10]. In a study of 30 surgically decompressed instances of vascular TOS in 25 patients, only one patient suffered a transient ischemic attack (TIA) . Among these, 22 cases had subclavian artery involvement. Cervical ribs (73%) were found to be the commonest predisposing factor for subclavian artery thrombotic disease in this study . One of the most important arterial pathologic changes caused by cervical rib in arterial TOS are partial or complete subclavian artery thrombosis or aneurysm .
We present the history of a 49-year-old male with a complete subclavian arterial thrombosis and both cerebellar and cerebral infarctions secondary to a right cervical rib and retrograde thromboembolisation.
A 49-year-old man was referred to us with a 3-day history of headache, pain and fluctuating weakness in the right arm, and a one-day history of acute dizziness, unsteadiness, and transient loss of vision in the right hemifield. He had hypertension, dyslipidemia, and 27-pack-year history of smoking. Six months earlier he was admitted to a local hospital due to pain and weakness when elevating his right arm. MR angiography showed a right brachial artery occlusion. Conservative treatment with aspirin 75 mg was initiated and the arm symptoms diminished.
Upon arrival at our hospital, the patient stated that the pain in the right arm was exacerbated by elevation, such as sleeping with his arms overhead. There was no history of neck trauma. His additional medications included irbesartan in combination with hydrochlorothiazide 300/25 mg and simvastatin 20 mg.
Blood pressure was not measurable and there was no detectable pulse in the right upper limb. On the left side, the blood pressure was 147/83 mmHg with a regular radial pulse of 72 beats per minute. Apart from left-sided hyperreflexia without Babinski sign, general medical and neurological examinations were unremarkable. Biochemical and hematological blood samples were normal.
Based on the suspicion of cerebral thromboembolism originating from the occluded subclavian artery, low molecular weight heparin was initiated at 10000 units twice a day, followed by warfarin (target International Normalized Ratio 2,0-3,0).
CT angiography performed twice over a period of 3 months following the initiation of anti-coagulation showed partial recanalisation in all affected arteries. Thrombus extension retrograde into the right carotid artery bifurcation was not present at the second CT angiography prior to surgery. Four months after the cerebral thromboembolism the patient underwent resection of the right cervical rib and first costa through a transaxillary approach. The cervical rib was attached to the upper surface of the first costa by a pseudoarticulation. Both the surgery and postoperative period were uneventful, and the combined anti-coagulant and anti-platelet therapies were continued postoperatively.
Our patient presented for six months with intermittent right upper extremity claudication due to pressure of cervical rib upon the right subclavian artery leading to thrombosis before cerebral thromboembolism. He was admitted to a local hospital six months before the recent cerebral infarction when thrombosis of the brachial artery was recognized. This is unusual in 49-year-old man. With a brachial artery thrombus, one should look proximally at the subclavian artery and regard the brachial artery thrombus as probably an embolus from the subclavian. At that time (six months ago) a cervical rib and subclavian artery occlusion should have been looked for and eventually repaired.
The first recognition that the syndrome of cervical rib with subclavian artery thrombosis could be complicated by combination of right upper extremity and cerebral thromboembolism was made by Gould in 1884  and again in 1887 . In Gould’s case, a 19-year-old male was described with “sickening pain” in his right hand , and an acute left arm paresis occurring three years later . The pathogenesis was assumed as a progressive obliteration of the brachial artery, although “there was noticed a great prominence of the right subclavian artery above the clavicle” and “a bony mass springing from each side of the lower two cervical vertebrae, larger on the right than the left side” [8, 9]. X-ray documentation of this compressive phenomenon was reported by Hoobler in 1942, who demonstrated bilateral cervical ribs in a patient with subclavian arterial thrombosis and cerebrovascular accident .
More recently, in a systematic review, Yamaguchi et al. reported ten patients with cerebral embolism from subclavian artery thrombotic pathology caused by a cervical rib or the first rib anomaly . In a study of 120 young stroke patients, retrograde embolism due to a right cervical rib-associated arterial lesion was the reported cause in only one patient . Retrograde propagation of subclavian thrombus can also involve the innominate artery .
Cervical rib represents an anomalous development of a rib, usually from the seventh cervical vertebrae , and may be associated with spinal anomalies elsewhere. The embryologic formation of cervical ribs is attributed to a conflict between forming ribs and plexuses . In the present case, the most likely predisposing factor of subclavian thrombosis was the presence of this anomaly.
It has been reported that a cervical rib is present in less than 1% of the population  . They are asymptomatic in 90% of the cases  and are found twice as frequently in females than in males (68% versus 32%, respectively) . Durham et al. found that 16 (73%) of 22 patients with subclavian artery compression had cervical ribs, and in five (31%) of these, bilateral cervical ribs were present . In addition, soft tissue anomalies, such as scar tissue after neck-shoulder trauma and clavicle trauma, may also predispose an individual to subclavian artery compression . Cervical ribs are recognised as complete or incomplete types . Only complete cervical ribs have been reported to produce vascular symptoms [17, 20].
Pain in the arm and hand is the prevailing symptom in subclavian artery compression, which typically presents in young, otherwise healthy patients with vigorous shoulder activity. The syndrome of occlusion is more common in athletes and baseball pitchers, golfers, and cricket bowlers in whom arm motions encourage contact with the artery and rib [6, 21].
Common findings on physical examination consist of a pulseless, pale and cold distal upper limb. In order not to delay the diagnosis and correct treatment of arterial compression, the clinician must differentiate such arm ischemia from Raynaud syndrome, vasospastic disorders, distal small-artery obstructive disease, or proximally large-artery occlusions which may result in this symptom complex.
The lumen of the subclavian artery becomes constricted owing to the compression of the base of interscalene triangle in which the subclavian artery pass [17, 22]. Chronic arterial spasm induced by the pressure of the cervical rib may increase flow velocity and shear stress at the affected arterial wall. These mechanical factors may damage the intima and trigger clotting, followed by thrombus formation, which in case of retrograde flow may break off to lodge in the cerebral region. Further arterial compression with increase in symptoms can occur during rotation and elevation of the arm [6, 21, 23].
In the present case, ischemia in both vertebrobasilar and carotid distribution were consequences of a thromboembolic migration from a bidirectional subclavian thrombus. In most reported cases of this unusual syndrome, the thrombosis occurred in the right subclavian artery and cerebral infarctions were caused by propagation of a thrombus through the carotid artery. Predilection of thromboembolism in the right cerebral and not cerebellar hemisphere is explained by the fact that only on that side the common carotid arises with the subclavian from the innominate . This route of embolisation is also explained due to the larger caliber of and less vascular resistance in the common carotid than vertebral artery . However, cerebellar infarction has been reported to occur if there is an extension of subclavian thrombus into the vertebral artery .
The syndrome of cervical rib with subclavian artery thrombosis is difficult-to-treat disorder. Decompression and vascular procedure is indicated when there is a failure to improve on conservative therapy  or where disability is manifested . In our case, removal of the right cervical rib was deferred in order to prevent collapse of the subclavian thrombus and additional embolisation to the brain. The patient did not have any vascular sequelae and was initially treated with combined anti-coagulant and anti-platelet therapy and followed at regular intervals. He underwent resection of the right cervical rib and first costa through a transaxillary approach four months after the cerebral thromboembolism. CT angiography showed partial recanalisation in all affected arteries prior to rib resection, and it was therefore not considered necessary with reconstructive vascular procedure.
In conclusion, cerebellar and cerebral infarctions due to the syndrome of cervical rib with subclavian artery thrombosis are unusual, however, when present, the consequences for the brain tissue involved are serious. Surgical removal, instead of conservative treatment, should be considered in a patient with subclavian artery compression due to a cervical rib to prevent additional embolic events.
Written informed consent was obtained from the patient for publication of this case report.
- Adson AW, Coffey JR: Cervical rib: a method of anterior approach for relief of symptoms by division of the scalenus anticus. Ann Surg. 1927, 85 (6): 839-57.View ArticlePubMedPubMed CentralGoogle Scholar
- Symonds CP: Two cases of thrombosis of subclavian artery with contralateral hemiplegia of sudden onset, probably embolic. Brain. 1927, 50: 259-260. 10.1093/brain/50.2.259.View ArticleGoogle Scholar
- Peet RM, Hendricksen JD, Anderson TP, Martin GM: Thoracic-outlet syndrome: evaluation of a therapeutic exercise program. Proc Staff Meet Mayo Clin. 1956, 31 (9): 281-7.PubMedGoogle Scholar
- Lee TS, Hines GL: Cerebral embolic stroke and arm ischemia in a teenager with arterial thoracic outlet syndrome: a case report. Vasc Endovascular Surg. 2007, 41 (3): 254-7. 10.1177/1538574407299780.View ArticlePubMedGoogle Scholar
- Naz I, Sophie Z: Cerebral embolism: distal subclavian disease as a rare etiology. J Pak Med Assoc. 2006, 56 (4): 186-8.PubMedGoogle Scholar
- Fields WS, Lemak NA, Ben-Menachem Y: Thoracic outlet syndrome: review and reference to stroke in a major league pitcher. AJR Am J Roentgenol. 1986, 146 (4): 809-14.View ArticlePubMedGoogle Scholar
- Al-Hassan HK, Abdul Sattar M, Eklof B: Embolic brain infarction: a rare complication of thoracic outlet syndrome. A report of two cases. J Cardiovasc Surg (Torino). 1988, 29 (3): 322-5.Google Scholar
- Gould AP: A case of spreading obliterative arteritis. Trans Clin Soc London. 1884, 17: 95-Google Scholar
- Gould AP: Further notes of a case of obliterative arteritis. Trans Clin Soc London. 1887, 20: 252-Google Scholar
- Hoobler SW: The syndrome of cervical rib with subclavian arterial thrombosis and hemiplegia due to cerebral embolism. N Engl J Med. 1942, 226: 942-944. 10.1056/NEJM194206112262402.View ArticleGoogle Scholar
- Davidovic LB, Kostic DM, Jakovljevic NS, Kuzmanovic IL, Simic TM: Vascular thoracic outlet syndrome. World J Surg. 2003, 27 (5): 545-50. 10.1007/s00268-003-6808-z.View ArticlePubMedGoogle Scholar
- Sanders RJ, Hammond SL, Rao NM: Thoracic outlet syndrome: a review. Neurologist. 2008, 14 (6): 365-73. 10.1097/NRL.0b013e318176b98d.View ArticlePubMedGoogle Scholar
- Yamaguchi R, Kohga H, Kurosaki M, Tamura M, Tanaka S, Tosaka M, Yoshimoto Y: Acute basilar artery occlusion in a patient with left subclavian artery occlusion due to first rib anomaly: case report. Neurol Med Chir (Tokyo). 2008, 48 (8): 355-8. 10.2176/nmc.48.355.View ArticleGoogle Scholar
- Awada A: Stroke in Saudi Arabian young adults: a study of 120 cases. Acta Neurol Scand. 1994, 89 (5): 323-8.View ArticlePubMedGoogle Scholar
- Tubbs RS, Muhleman M, Miller J, Shoja MM, Loukas M, Wellons JC, Oakes WJ: Cervical ribs with neurological sequelae in children: a case series. Childs Nerv Syst. 2011, Oct 18 [Epub ahead of print]Google Scholar
- Jones FW: The Anatomy of Cervical Ribs. Proc R Soc Med. 1913, 6 (Clin Sect): 95-113.PubMedPubMed CentralGoogle Scholar
- Sanders RJ, Hammond SL: Management of cervical ribs and anomalous first ribs causing neurogenic thoracic outlet syndrome. J Vasc Surg. 2002, 36 (1): 51-6.View ArticlePubMedGoogle Scholar
- Sanders RJ, Haug C: Thoracic outlet syndrome: a common sequela of neck injuries. 1991, JB Lippincott, Philadelphia, 40-1. 75;129–85Google Scholar
- Durham JR, Yao JS, Pearce WH, Nuber GM, McCarthy WJ: Arterial injuries in the thoracic outlet syndrome. J Vasc Surg. 1995, 21 (1): 57-69. 10.1016/S0741-5214(95)70244-X. discussion 70View ArticlePubMedGoogle Scholar
- Short DW: The subclavian artery in 16 patients with complete cervical ribs. J Cardiovasc Surg (Torino). 1975, 16 (2): 135-41.Google Scholar
- Strukel RJ, Garrick JG: Thoracic outlet compression in athletes a report of four cases. Am J Sports Med. 1978, 6 (2): 35-9. 10.1177/036354657800600201.View ArticlePubMedGoogle Scholar
- Huang JH, Zager EL: Thoracic outlet syndrome. Neurosurgery. 2004, 55 (4): 897-902. 10.1227/01.NEU.0000137333.04342.4D. discussion 902–3View ArticlePubMedGoogle Scholar
- Criado E, Berguer R, Greenfield L: The spectrum of arterial compression at the thoracic outlet. J Vasc Surg. 2010, 52 (2): 406-11. 10.1016/j.jvs.2010.03.009.View ArticlePubMedGoogle Scholar
- Prior AL, Wilson LA, Gosling RG, Yates AK, Ross Russell RW: Retrograde cerebral embolism. Lancet. 1979, 2 (8151): 1044-7.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/12/48/prepub
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