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Optimizing the use of expert panel reference diagnoses in diagnostic studies of multidimensional syndromes
© Handels et al.; licensee BioMed Central Ltd. 2014
Received: 5 July 2013
Accepted: 23 September 2014
Published: 4 October 2014
In the absence of a gold standard, a panel of experts can be invited to assign a reference diagnosis for use in research. Available literature offers limited guidance on assembling and working with an expert panel for this purpose. We aimed to develop a protocol for an expert panel consensus diagnosis and evaluated its applicability in a pilot project.
An adjusted Delphi method was used, which started with the assessment of clinical vignettes by 3 experts individually, followed by a consensus discussion meeting to solve diagnostic discrepancies. A panel facilitator ensured that all experts were able to express their views, and encouraged the use of argumentation to arrive at a specific diagnosis, until consensus was reached by all experts. Eleven vignettes of patients suspected of having a primary neurodegenerative disease were presented to the experts. Clinical information was provided stepwise and included medical history, neurological, physical and cognitive function, brain MRI scan, and follow-up assessments over 2 years. After the consensus discussion meeting, the procedure was evaluated by the experts.
The average degree of consensus for the reference diagnosis increased from 52% after individual assessment of the vignettes to 94% after the consensus discussion meeting. Average confidence in the diagnosis after individual assessment was 85%. This did not increase after the consensus discussion meeting. The process evaluation led to several recommendations for improvement of the protocol.
A protocol for attaining a reference diagnosis based on expert panel consensus was shown feasible in research practice.
Evidence on diagnostic accuracy is often produced in cross-sectional studies by comparing the result of a test under evaluation (the index test, e.g. a newly developed blood test) with the actual presence or absence of a target condition . Ideally, a gold standard to determine the presence of this target condition is available, which is an error-free classification in all patients, blinded from the index test result, and performed within a short interval of time . There are, however, many conditions for which such a gold standard does not exist. In that case, an alternative is then to rely on a clinical reference standard: the best available way for arriving at a clinical classification. One option is then to use a panel of experts who, based on the available information, identify those with the target condition among the persons being tested ,.
An example for a disease for which no test fulfils the criteria for a gold standard is Alzheimer's disease (AD). It is defined by a gradual onset of symptoms, deterioration of cognition leading to dementia, and no evidence of another medical comorbidity or medication that could affect cognition . An AD diagnosis is traditionally mainly based on clinical judgement. Recently biomarkers have been given a prominent role in new diagnostic research criteria for AD - and require validation . Several reference standards have been discussed for AD. A post-mortem neuropathological examination has been criticized for imperfect inter-observer reliability and imperfect association with cognitive impairment or dementia ,. Another reference standard is to follow up a patient in the pre-dementia phase until a clinical diagnosis of AD-type dementia can be made. This requires a long follow-up period to ensure that all patients with a neurodegenerative disease at baseline decline to the level of dementia within that period ,.
Several studies have reported on the use of an expert panel to assign a final diagnosis -. Most studies that rely on an expert panel insufficiently described the rationale behind many of the methodological choices: the basic approach, the number and choice of experts that should be invited, the information that must be supplied to enable expert consensus, the specific questions to be asked, and how to arrive at consensus. Leaving the rationale behind many of these elements unknown makes it difficult to reproduce their findings.
We have developed a protocol for a consensus panel reference diagnosis in AD based on clinically relevant decline as judged by a clinician. We evaluated its feasibility in a pilot project. Based on our findings, we provide a number of recommendations for other researchers considering the use of a consensus panel diagnosis.
We searched the literature using PubMed for the choices to be made with regard to the methodology of a consensus panel diagnosis. Our protocol was then drafted based on the recommendations from the literature, and tested in a pilot study.
A panel was composed consisting of 3 clinical experts (FV, AL and E. Tan MD) with complementary expertise on neurology, geriatrics and psychiatry. Their clinical experience ranged from 1 to more than 10 years.
In the first step, the 3 experts were invited to assess each of the 11 patient cases individually by logging on to a web-based questionnaire. In this questionnaire information on each case was provided in a staged fashion. This step consisted of two stages:
Questionnaire used for rating the vignettes
1a) What is the most probable syndrome for this patient?
Subjective cognitive impairment
Mild cognitive impairment
1b) the most probable aetiology for this patient?
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
2a) What is the most probable aetiology for this patient?
Other neurodegenerative disease, namely _______________
No neurodegenerative disease, namely ________________
2b) How certain are you of this?
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
3a) In your opinion, what will be the most likely course of cognitive and/or daily functioning within 2 years?
3b) How certain are you of this expectation?
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
2. In stage 2, the experts were asked to individually answer the same three questions, though now based on information which included the 2-year follow up of the symptoms that was added to the information from stage 1. The same three questions from Table 1 were asked except the last one “What will be the most likely course of decline” was rephrased to “what was the course of decline”.
See Additional file 1 for an example of the available information to the experts in stage 1 and 2. After each stage, the answers were frozen and could not be adjusted retrospectively. No information on biomarkers in cerebrospinal fluid markers, positron emission tomography scans, advanced diffusion tensor, or resting state functional magnetic resonance imaging was provided as this could result in context bias .
In the second step, two independent researchers (RH and CW) reviewed the responses. All cases for which all three experts had given identical answers regarding the syndrome, aetiology and prognosis for stage 1 as well as stage 2 were identified. Levels of certainty for these cases were averaged. All cases for which there was no agreement on any of the three questions were forwarded to the next step.
In the third step, all three experts participated in a face-to-face panel discussion meeting. For each case, a summary of the individual answers to the three questions was presented as well as all relevant clinical information, identical to the one in the first step. The experts were invited to express and exchange their arguments for the answers to the questions and asked to consider whether, in the light of their colleagues’ assessments, they would like to alter their conclusion. A panel facilitator ensured that all participants were able to express their views and encouraged the use of argumentation to arrive at a specific diagnosis, until consensus among all experts was reached. No time limit was set for the discussion.
The care-as-usual diagnosis was defined as the diagnosis based on the information of stage 1 at the moment consensus was reached (consensus could have been reached in step 1 before the discussion meeting, because the 3 experts scored identical on the web-based questionnaire, or after the panel discussion meeting in step 3, because the experts scored different in the web-based questionnaire of step 1 and required the discussion meeting to reach consensus). The information at stage 1 represented the information available from a first visit to a memory clinic: baseline medical history, neurological and physical examination findings, psychiatric and clinimetric assessments (see Additional file 1).
The reference diagnosis was defined as the diagnosis based on the stage 2 information at the moment consensus was reached (consensus could have been reached before the discussion meeting in step 1 or after the panel discussion meeting in step 3). The information at stage 2 contained all available information from stage 1 at baseline and the 2-year course of symptoms (see Additional file 1).
Afterwards, the experts were asked to complete a process evaluation questionnaire (see Additional file 2) in which they were asked about their experiences regarding the assessment of cases and the consensus discussion, and were asked to provide feedback and suggestions to improve the protocol.
The cases for the evaluation consisted of a sample of 11 patients who had visited the memory clinic of the Maastricht University Medical Centre in the Netherlands in 2009 and 2010 and were suspected of having a primary neurodegenerative disease according to the following eligibility criteria : Mini-Mental State Examination (MMSE)  score 20 or higher, Clinical Dementia Rating (CDR) , between 0 and 1, and availability of a reliable informer or proxy. Subjects were excluded if they had normal pressure hydrocephalus, Huntington’s disease, transient ischaemic attacks or cerebral vascular accidents less than 2 years ago, or a previous psychiatric history. Informed consent was obtained from both the patient and the informal caregiver. Subjects without any follow-up assessment (due to refusal or other reasons) were excluded from this research. The sample was selected such that it included similar proportions of patients with subjective memory complaints, mild cognitive impairment (MCI) and dementia. The hospital’s medical ethics committee approved this study.
The clinical information included in the vignette (see Additional file 1 for an example) was based on guidelines from the American Academy of Neurology  and European Federation of the Neurological Societies .
Patient and informant history (medical history, family history, education, co-morbidities, behavioural and psychological symptoms, and activities of daily living) were retrieved from an open interview with both patient and informal caregiver. A neurological and physical examination, and assessment of co-morbidities was performed by a clinician. Clinical tests included the MMSE, CDR, Geriatric Depression Scale-15 (GDS-15) , Neuropsychiatric Inventory  and Disability Assessment for Dementia (DAD) . Atrophy measurements and white matter lesions were assessed on 3 T MRI scan images by a neuroradiologist. Medial temporal lobe atrophy (MTA) scores, as well as Fazekas scores were used to quantify hippocampal atrophy and the severity of white matter lesions. Neuropsychological examination consisted of a battery of cognitive tests administered by a neuropsychologist. Tests included Rey’s Verbal Learning Test ,, Visual Association Test , and Digit-Span  to assess memory; Letter Digit Substitution Test  to assess mental processing rate; and Stroop Color-Word Test  and Trail Making Test , to assess attention, concentration and interference. Raw scores were converted to z-scores, adjusted for age, education level and gender. All assessments took place at baseline and at 12 and 24 months follow-up at the memory clinic, except the MRI scan which was performed only at baseline.
In the analysis we described the care-as-usual and reference diagnoses that were set, and compared the degree of consensus before and after the discussion meeting for the 11 cases. We additionally calculated the average level of confidence in the diagnostic conclusions.
The baseline patient sample included 8 males and 3 females, with a median age of 78 years (range: 49–86). The median MMSE score was 28 (range: 22–30), CDR was 0.5 (range: 0–1) and DAD was 93% (range: 77–100).
Confidence and percentage agreement among experts during individual assessment and consensus discussion of 11 cases
Before consensus panel meeting (internet form)
After consensus panel meeting
Before consensus panel meeting (internet form)
After consensus panel meeting
Degree of consensus (average)
Consensus on syndrome
Consensus on aetiology
Consensus on disease course
Confidence in the diagnoses (average)
The degree of consensus over all three questions (syndrome, aetiology and disease course) was higher after the panel consensus meeting (91% for the care-as-usual and 94% for the reference standard) compared to before the meeting (70% and 52% respectively). The average level of confidence in the individually established diagnoses was 76% for the care-as-usual diagnosis and 85% for the reference diagnosis. These did not change after the panel discussion meeting.
It took the experts individually on average 6 minutes and 6 seconds to assess a case via the internet form, and 8 minutes and 38 seconds to discuss a discrepant case during the consensus panel meeting.
Results of the evaluation questionnaire
Instructions, procedure and diagnostic questions were clear
Estimated time per case to fill in the internet form
Diagnosis reflects medical practice
Consensus procedure considered valid to determine a reference diagnosis (scale 0–10)
Sufficient information available to determine a diagnosis
Influence of baseline diagnosis on reference diagnosis (scale 0–10)
All panel members had equal shares in the discussion*
Felt impeded in expressing their opinion
Years of experience needed to participate in an expert panel (average, range)*
Two-year follow-up on disease course is sufficient to determine a reference diagnosis
Three experts is enough
During the panel discussion meeting, the experts indicated that they considered the patient’s history information to be decisive if it contradicted test outcomes of clinical scales such as MMSE or DAD. They also discussed what extent of decline would be sufficient to mark a case as ‘actual decline’. They indicated that a patient did not necessarily have to decline to a more severe syndrome, but could also decline to a clinically relevant lower state of cognition and/or functioning within a syndrome label.
In a pilot study, we tested a 3-step protocol for establishing a consensus panel diagnosis using clinical vignettes based on 11 cases in the field of cognitive disorders. The use of an expert panel to attain consensus on a reference diagnosis was considered feasible in research practice.
Two possible forms of bias can occur in a cohort-based diagnostic research as applied in this pilot study: incorporation bias and review bias.
Incorporation bias occurs if information that is used to establish the care-as-usual or biomarker-driven diagnosis is also used to establish the reference standard . If for example a patient’s biomarker profile is available to a panel of experts who assign the reference diagnosis it could lead to overestimation of the biomarker’s accuracy, because the association between biomarker and reference standard is artificially inflated. This could easily occur when the standard medical practice diagnosis of AD-type dementia at follow up is used as a longitudinal reference standard, because biomarkers are often used in medical research practice. Many reports on studies that apply such longitudinal medical practice diagnosis as a reference standard provide insufficient information on whether the clinicians were blind for the biomarker results when they set the medical practice diagnosis after having followed up a patient . Incorporation bias can also occur when diagnostic information from care-as-usual is available to the experts when they assign the reference diagnosis. In contrast to the inclusion of a patient’s biomarker profile, as explained above, the care-as-usual baseline information can hardly be omitted since a starting point is required for the reference diagnosis (i.e. the level of decline). It is considered likely that the care-as-usual information provides a ‘small piece of all available information including all follow-ups’ and that the biomarker profile information will receive ‘much weight in the consensus judgement’ when experts set the reference diagnosis . We therefore recommend to incorporate the baseline clinical information but no biomarker information in a reference standard.
Follow-up of pre-dementia patients until a diagnosis of AD-type dementia is a widely applied reference standard in validating biomarkers . When using this reference standard a normal biomarker profile is considered incorrect if a pre-dementia patient does not develop AD-type dementia over time. This approach can lead to an incorrect classification if this patient declines but not sufficiently to reach the state of dementia (i.e. the condition is present but not picked up by the reference standard). On the opposite, an abnormal biomarker profile is considered correct if a pre-dementia patient develops AD-type dementia after a long period of time, for example in 10 years. This approach can be debated in case AD pathology was absent when the subject was tested with the biomarker.
To reduce the extent to which these errors in the reference standard might occur we considered the concept of decline itself, instead of decline to the absolute level of dementia. We do not know what the optimal follow-up time is to establish decline as a valid reference diagnosis. In our opinion, the optimal follow-up period is between 3 and 5 years, as the experts indicated that 2 years may not be sufficient, especially when treatment of cognitive symptoms, e.g. with cholinesterase inhibitors, is started. A follow-up longer than 5 years was considered clinically irrelevant and increase the potential of errors in the reference standard.
The use of a heterogeneous panel composed of experts with different backgrounds, though within the area of interest, has been recommended in the literature ,. Gabel et.al  emphasized the importance of selecting experts who are likely to make different types of errors of judgment. Heterogeneity of backgrounds could also help prevent domination by a particular expertise. Other studies applying a consensus diagnosis have used a variety of expertise for their expert panel ,. Gabel et al.  found no differences in diagnostic accuracy between a trainee panel and an expert panel though they did not recommend a specific ‘amount’ of required experience. In our study the experts indicated that between 1 and 5 years of experience in the particular field of expertise was necessary to establish a valid diagnosis.
The limited clinical experience of one of our experts might be the reason why one of the other panel members indicated that not everyone had an equal share in the discussion. Perhaps requiring a larger number of years of clinical experience might have helped prevent some of the panel members dominating the discussion. Previous studies showed a large variety regarding the number of experts in the panel, though no specific number was recommended ,. In our study all experts shared the opinion that having 3 panel members was sufficient to establish a valid diagnosis. The qualities of the experts were generally considered more important than the size of the expert panel group. An uneven number of experts could facilitate the decision process if a majority vote is used . Studies reported on in the literature used 2 to 6 experts to determine a consensus diagnosis -,.
The original Delphi methodology was adjusted in our project since we did not blind the experts from each other’s opinion in the panel discussion ,. Since this might cause bias towards dominant experts, a panel facilitator ensured that all participants were enabled to express their views ,. An alternative, less time–consuming, method could be to adopt a majority decision after individual assessment ,,, which has been reported to have similar diagnostic accuracy as forced consensus . Most studies suggested that experts should apply medical practice diagnostic guidelines, though without imposing strict decision rules.
Video recordings, which could reveal valuable subtle information on patient history , were not provided in our study, due to limited time and resources. Instead, we provided a written summary of the clinical history in which an independent researcher had highlighted the most important aspects.
Recommendations for adjustments to the protocol
Based on the results of the evaluation questionnaire, a number of adjustments to the consensus protocol could be recommended.
Information on clinical history at follow-up should be included to arrive at a reference diagnosis.
A 2-year follow-up period for a reference diagnosis that should reflect the best available way for arriving at a clinical classification was considered too short, though the experts could not provide a specific period required.
Experts invited to the panel should have a minimum of 3 years of clinical experience.
In some cases the expert panel concluded after the group discussion that no consensus could be reached. As proposed in the literature ,, a majority decision could be adopted in these cases to prevent inefficient use of discussion time.
One expert recognized 1 case from the clinic. It is recommended inviting only experts who have had no direct interaction with the patients under evaluation.
Initially we included several non-neurodegenerative diagnostic options, which resulted in irrelevant discussions. These were therefore replaced by the question: ‘No neurodegenerative disease, namely…’.
The login procedure consisted of several steps. When implementing this procedure in research practice, the required time and the complexity of the procedure should be minimized to maximize the willingness of experts to devote their time.
The final protocol can be found in Additional file 3.
Several limitations apply to this study. Not imposing strict decision rules allowed for different views within the panel on how to determine a diagnosis. For example, different sources of information were used to determine an objective memory deficit to distinguish between subjective memory complaints and MCI, and some experts always expected a decline if a neurodegenerative disease was identified. A preparatory discussion among all experts might have reduced discussion time and could increase our understanding of the concept being assessed by the experts.
Another limitation is that the 3-day period that elapsed between filling in the internet form and the consensus panel meeting may have been too short. The experts may have remembered the follow-up information from the internet-based questionnaire when discussing the care-as-usual diagnosis during the consensus panel meeting, which may have resulted in test review bias.
Although the protocol we developed was a practical and transparent method to assign a reference diagnosis, it must be kept in mind that it represents a compromise between available time and resources versus minimisation of bias. The optimal design to evaluate a diagnostic test would be a randomised controlled trial to determine the effects on patient outcome from undergoing the test and the actions taken upon the result. Although no disease-modifying therapies in the pre-dementia phase are available for AD, there is still an interest in the validity of new biomarkers to distinguish disease from non-disease or to enable future planning for patients. When such treatments become available, evidence on the level of diagnostic accuracy can strengthen clinical decision-making ,.
Our aim was to assess the feasibility of establishing a consensus panel diagnosis, for the purpose of studies into cognitive decline and AD, and to establish a protocol for such a consensus panel diagnosis. The protocol was evaluated in a pilot study and the results indicate that this protocol was feasible in research practice.
AL designed the study and was one of the three clinical experts. CW designed the study and was panel facilitator for the expert panel discussion meeting. FV (project leader) designed the study and was one of the three clinical experts. JS (project leader) designed the study. MJ designed the study. PA designed the study. PB designed the study. RH designed the study, organized the expert panel meeting, performed the analysis, and drafted the manuscript. All authors read and approved the final manuscript.
We would like to thank E. Tan MD for her role as one of the three clinical experts. This research was performed within the framework of CTMM, the Center for Translational Molecular Medicine (www.ctmm.nl), project LeARN (grant 02 N-101). Source of funding for CW, PA and RH was the CTMM framework, grant 02 N-101. The funding body had no role in the study design, the collection, analysis or interpretation of data, or the writing of the manuscript. The funding body checked the manuscript for possible infringement of intellectual property rights and approved the manuscript for publication without suggesting any revisions. The source of funding for the manuscript preparation was the CTMM framework, grant 02 N-101.
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