Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium
© The Author(s). 2016
Received: 29 April 2016
Accepted: 2 August 2016
Published: 11 August 2016
Magnesium has a regulatory role in the excitability of cell membranes, and is also a cofactor in the phosphorylation of thiamine. Hypomagnesemia has been associated with coronary vasospasm, but its role in cerebrovascular pathology is controversial, and cerebral vasospasm exclusively attributable to hypomagnesemia has not been reported in humans.
We report the case of a 51-year-old man in whom uncontrollable vomiting, treatment with omeprazole and thiazide, and renal impairment lead to a severe hypomagnesemia (magnesium below the level of detection in blood tests), which secondarily caused Wernicke’s encephalopathy and vasospasm in multiple cerebral arteries (seen with cerebral angiography and CT angiography) that presented with a complete right hemisphere neurological deficit. These disturbances completely resolved when magnesium levels were normalized and subsequent neuroimaging tests confirmed the resolution of angiographic changes.
Our case suggests that hypomagnesemia should be considered in the differential diagnosis of patients with neurological symptoms and predisposing causes.
KeywordsHypomagnesemia Wernicke encephalopathy Cerebral vasospasm Cyclic vomiting syndrome Case report
Magnesium is the most abundant intracellular divalent cation and the fourth most abundant element in the body. The majority of this mineral is localized in the bones and soft tissues, only 1 % resides in the extracellular fluids . Magnesium balance is maintained by means of intestinal absorption in the small bowel, mostly in the ileum and distal part of jejunum, and renal excretion. The kidneys are crucial in magnesium homeostasis. 70 % of the magnesium filtered is reabsorbed in the thick ascending limb of the loop of Henle. It is estimated that an adult needs an intake of 255–350 mg daily . Conditions that can lead to hypomagnesemia include alcoholism, diabetes, malabsorption (Crohn’s disease, ulcerative colitis, coeliac disease, short bowel syndrome), gastrointestinal loses (biliary or intestinal fistula, large-volume diarrhea or vomiting) endocrine causes (hyperaldosteronism, hyperparathyroidism, syndrome of inappropriate antidiuretic hormone secretion, hypercalcemia, hypercalciuria), renal disease (renal failure, dialysis, intrinsic tubular disorders) and medication use (diuretics, proton pump inhibitors, antibiotics, chemotherapeutic agents) .
The principal function of magnesium in the human body is structural, mainly in bones and teeth. However, according to its ionic characteristics, it also plays a role in the regulation of the excitability of neuromuscular membranes. Magnesium works as a cofactor in many enzymatic reactions such as ATP kinase reactions or the activation of thiamine by its phosphorylation to thiamine pyrophosphate [1, 2]. Magnesium is also an antagonist of the N-methyl-d-aspartate (NMDA) receptor [1, 3], and has direct vasodilatory effects due to various mechanisms. Hypomagnesemia is thought to lead to an increase in vascular smooth muscle tone and reactivity, its association with acute focal vasospasm in coronary arteries has been known for decades , albeit cerebral vasospasm exclusively attributable to hypomagnesemia in humans has not been reported. We report a case of vasoconstriction in multiple cerebral arteries and Wernicke’s encephalopathy (WE) secondary to hypomagnesemia.
Acute hypomagnesemia can produce different symptoms depending on the severity of the deficiency. Early signs of hypomagnesemia are non-specific and include loss of appetite, lethargy, nausea, vomiting, fatigue and weakness. The association with hypophosphatemia and hypocalcaemia is frequent. Subsequently, lower magnesium levels can result in tremor, muscle cramps, tetany and generalized seizures . On the other hand, chronic magnesium deficiency is not rare these days, however, it usually remains asymptomatic. This condition has been associated with anxiety, depression, other psychiatric disorders and dementia . Hypomagnesemia is a known cause of Wernicke`s encephalopathy, and frequently these cases are refractory to treatment with thiamine, as magnesium is a cofactor in thiamine phosphorylation, needed for its activation . Our patient developed WE, without an associated Korsakoff syndrome as he did not present with amnesia. These symptoms were completely reversed after two weeks of supplementation with magnesium and thiamine.
As previously mentioned, magnesium plays a key role in the regulation of the excitability of cell membranes. It antagonizes the NMDA receptor [1, 3] and cell surface and intracellular voltage-gated calcium channels [3, 5], thereby impeding calcium entry to ischemic neurons, which is crucial for the activation of cellular apoptotic pathways. Due to these actions, magnesium has been shown to be a neuroprotective agent in different models of cerebral ischemia, demonstrating improvement of prognosis after a cardiac arrest , in pre-term infant hypoxic-ischemic injury , during cardiac by-pass surgery  and during carotid endarterectomy . Nonetheless, recent trials that evaluated intravenous magnesium versus placebo in acute stroke have shown no benefit to this treatment, nor remarkable adverse events [10, 11].
According to its cardiovascular functions, magnesium deficiency has been linked to vascular risk factors such as hypertension, atherosclerosis and diabetes, as well as having a statistical association with greater risk of coronary heart disease, myocardial infarction, sudden cardiac death and stroke . This ion has direct vasodilatory effects in the cerebral vasculature by antagonizing endothelin-1, neuropeptide Y and angiotensin II, whilst at the same time exerting a calcium antagonist effect on vascular smooth muscle [3, 5]. Several trials reported its benefit as a vasodilator agent improving symptomatic vasospasm and delayed ischemia in aneurysmal subarachnoid hemorrhage (SAH) [12, 13], and for years it was used routinely in the treatment of these problems. However, recent trials evaluated the effect of intravenous magnesium for aneurysmal SAH and showed no benefit in any of their objectives [14, 15]. It is possible that prolonged delay of the administration of magnesium and its limited passage through the blood–brain barrier after intravenous supplementation [5, 16] have limited its potential benefit. Furthermore, hypomagnesemia has been previously described as a cause of human coronary [4, 17] and retinal  vasospasm, but cerebral vasospasm directly attributable to hypomagnesemia has previously been proven only in animals models . This may be because cerebral circulation is less sensitive to variations in magnesium concentrations due to the blood–brain barrier, and mild or moderate hypomagnesemia may have no effect on the cerebral vasculature. In the case of our patient, massive vomiting, renal impairment and previous treatment with omeprazole and thiazide lead to a severe hypomagnesemia, which caused secondary vasoconstriction in multiple cerebral arteries, in addition to WE. These disturbances were resolved when serum magnesium levels were normalized, which further confirms the cause-and-effect relationship. It is also possible that adult cyclic vomiting syndrome, which has been associated with autonomic vascular changes [20, 21], could have played a role in the cerebral vasospasm of the patient, albeit previous studies did not report any cerebrovascular event, so it is difficult to establish a clear association in this case. As to why our patient developed cerebral vasospasm and not vasospasm at other locations remains unknown. In the same way, we cannot give a feasible explanation for why these changes only occurred in the right hemisphere and not in both. Further studies in this area are needed to confirm these hypotheses.
In conclusion, hypomagnesemia should be considered in the differential diagnosis of patients with neurological symptoms and predisposing causes for magnesium deficit. To the best of our knowledge, we have not found any other reported cases of cerebral vasospasm attributable to hypomagnesemia in humans in the literature. This may be an underdiagnosed condition which should be considered because rapid detection and correction of serum magnesium levels would completely resolve the symptoms. Further studies are needed to confirm these hypotheses.
NIHSS, National Institute of Health Stroke Scale; NMDA, N-methyl-d-aspartate; SAH, subarachnoid hemorrhage; WE, Wernicke’s encephalopathy
The authors would like to thank the patient and his family for their cooperation and consent in relation to this study. We also want to thank the Research Committee of the Gerencia de Atención Integrada of Albacete for the support given for the publication of this article.
None funding declared
Availability of data and materials
Data of the clinical history of the patient (discharge summary, blood tests and radiological tests) will not be shared to maintain his anonymity. However, these data are available for review by the by the Editor-in-Chief of this journal.
SGM, FHF, ASL interviewed, diagnosed and treated the patient. JZ, JPR performed the radiological tests, evaluated the neuroimaging findings and gave important clinical opinions. ASL drafted the manuscript. FHF, TS participated in the design of the case report and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. The publication of this manuscript was approved by the Clinical Research Ethics Committee of the Complejo Hospitalario Universitario de Albacete.
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