Open Access

Erratum to: Exploring the effects of coexisting amyloid in subcortical vascular cognitive impairment

  • Elizabeth Dao1,
  • Ging-Yuek Robin Hsiung2,
  • Vesna Sossi3,
  • Claudia Jacova4,
  • Roger Tam5, 6,
  • Katie Dinelle7,
  • John R. Best1 and
  • Teresa Liu-Ambrose1, 8Email author
BMC NeurologyBMC series – open, inclusive and trusted201616:157

https://doi.org/10.1186/s12883-016-0673-5

Published: 31 August 2016

The original article was published in BMC Neurology 2015 15:197

Erratum

After publication of the original article [1], it came to the authors’ attention that there were data entry errors in the following variables: age, sex, education, MOCA, WML volume, and ADAS-Cog. Changes have been made to Tables 1, 2, 3 and 4, to reflect the updated results, which are published in their correct version here. However, the authors note that the study conclusions have not changed.
Table 1

Descriptive characteristic

Variable

Mean

SD

Age

71.73

7.91

Female Sex, No. (%)

7

32

Education, No. (%)

 High school education

6

27

 Trade or professional certificate or diploma

2

9

 University education

14

64

MMSE (max. score 30)

27.50

1.95

MOCA (max. score 30)

23.32

2.08

WHR

0.91

0.08

BMI

26.95

4.78

PIB-positive, No. (%)

6

27.27

Global PIB BPND

0.07

0.23

WML volume (mm3), n = 16

2004.40

2761.15

Cognitive Assessments

 ADAS-Cog (max. score 70)

9.63

3.88

 Exit-25 (max. score 50)

10.59

4.38

 Stroop CW-C, sec.

61.44

26.01

 Trails B-A, sec.

50.51

24.84

 Digits F-B, sec.

3.23

2.79

SD Standard Deviation, MMSE Mini-Mental State Examination, MOCA Montreal Cognitive Assessment; WHR Waist-to-Hip Ratio, BMI Body Mass Index, ADAS-Cog Alzheimer’s Disease Assessment Scale – Cognitive subscale, Exit-25 Executive Interview Test, Stroop CW-W Stroop Color Words minus Stroop colored x’s, Trails B-A Trails B (numbers and letters) minus Trails A (numbers), Digits F-B Digits Forwards minus Digits Backwards

Table 2

Correlation matrix

 

PIB BPND

Age

Education

APOE ε4

ADAS-Cog

MOCA

EXIT 25

Digits

Stroop

Trails

PIB BPND

          

Age

-0.00

         

Education

-0.23

-0.39

        

APOE ε4

0.36

0.09

-0.20

       

ADAS-Cog

0.53*

0.16

-0.11

0.53*

      

MOCA

-0.54*

-0.20

0.06

-0.11

-0.45*

     

EXIT-25

0.13

0.20

-0.20

0.25

0.49*

-0.52*

    

Digits

0.02

0.17

-0.35

-0.45*

-0.30

0.13

-0.04

   

Stroop

0.17

-0.06

0.02

-0.11

0.27

-0.29

0.34

0.04

  

Trails

0.19

-0.08

-0.25

0.48*

0.15

-0.18

0.29

0.01

0.13

 

*significant at p ≤ 0.05

Table 3

Multiple linear regression models assessing the contribution of PIB retention on ADAS-Cog

Independent variables

R2

Adjusted R2

R2 Change

Unstandardized B (Standard Error)

Standardized β

P- Value

Model 1

PIB BPND

0.28

0.24

-

9.09 (3.29)

0.53

0.01

Model 2

Step 1

0.30

0.18

0.30

   

Age

   

0.07 (0.11)

0.14

0.54

Education

   

0.41 (1.86)

0.05

0.83

APOE ε4

   

4.30 (1.64)

0.53

0.02

Step 2

0.44

0.31

0.15*

   

Age

   

0.09 (0.10)

0.18

0.37

Education

   

1.15 (1.74)

0.14

0.52

APOE ε4

   

3.20 (1.59)

0.39

0.06

PIB BPND

   

7.23 (3.42)

0.42

0.05

*significant at p ≤ 0.05

Table 4

Multiple linear regression models assessing the contribution of PIB retention on MOCA

Independent variables

R2

Adjusted R2

R2 Change

Unstandardized B (Standard Error)

Standardized β

P- Value

Model 1

PIB BPND

0.29

0.26

-

-5.00 (1.74)

-0.54

0.01

Model 2

Step 1

0.05

-0.11

0.05

   

Age

   

-0.06 (0.07)

-0.21

0.41

Education

   

-0.22 (1.16)

-0.05

0.85

APOE ε4

   

-0.43 (1.02)

-0.10

0.68

Step 2

0.37

0.22

0.32*

   

Age

   

-0.07 (0.06)

-0.28

0.20

Education

   

-0.80 (0.99)

-0.18

0.43

APOE ε4

   

0.44 (0.91)

0.10

0.63

PIB BPND

   

-5.71 (1.95)

-0.62

0.01

*significant at p ≤ 0.05

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Djavad Mowafaghian Centre for Brain Health, University of British Columbia
(2)
Department of Medicine, University of British Columbia
(3)
Department of Physics and Astronomy, University of British Columbia
(4)
School of Professional Psychology, Pacific University
(5)
Department of Radiology, University of British Columbia
(6)
MS/MRI Research Group, University of British Columbia
(7)
PET Group, Vancouver Hospital and Health Science Centre, Brain Research Centre
(8)
Department of Physical Therapy, University of British Columbia

Reference

  1. Dao E, Hsiung GY, Sossi V, Jacova C, Tam R, Dinelle K, et al. Exploring the effects of coexisting amyloid in subcortical vascular cognitive impairment. BMC Neurol. 2015;15:197. doi:https://doi.org/10.1186/s12883-015-0459-1.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2016

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