Secondary pallidonigral degeneration mimicking recurrent acute stroke in clinical presentation and magnetic resonance imaging: a case report
BMC Neurology volume 17, Article number: 215 (2017)
Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration following a previous putaminal infarct, which was diagnosed through diffusion-weighted (DWI) and T2-weighted imaging (T2WI).
A 64-year-old man complained of an acute relapse of right-lower-limb weakness following a cerebral infarction 2 months before presentation. Recurrent cerebral stroke was initially diagnosed in the emergency room. DWI of the brain revealed a subacute to chronic infarct in the left putamen and new acute cytotoxic edema in the left substantia nigra (SN) and globus pallidus while T2WI also showed hyperintensity in the same regions. The SN was outside the aforementioned middle cerebral arterial territory, which includes the putamen. These findings are compatible with the diagnosis of acute pallidonigral injury secondary to striatal infarction. The patient had fully recovered from his right-lower-limb weakness after 1 month.
Secondary pallidonigral degeneration may mimic recurrent stroke. DWI along with T2WI facilitates elucidation of this clinicopathological entity, and thus unnecessary treatment can be avoided.
Secondary pallidonigral degeneration is a rare clinicopathological entity in which excitotoxicity occurs in the neurons of the globus pallidus and substantia nigra (SN) following transneuronal degeneration (TND) caused by prior upstream brain injury, usually in the putamen. Diffusion-weighted imaging (DWI) is sensitive to acute cytotoxic edema in regions with TND because it exhibits reduced apparent diffusion coefficient (ADC) values [1, 2]. Patients with secondary degeneration may present with new or prolonged neurological deficits that could be mistaken for other pathological entities and mislead clinical management . This paper reports a case that emphasizes excitotoxicity and magnetic resonance imaging (MRI) findings.
A 64-year-old man with a history of hypertension and type 2 diabetes mellitus complained of an acute relapse of right-lower-limb weakness following a cerebral infarction 2 months before presentation. In the emergency room, he presented with reduced muscle power in his right lower extremity and no signs of dysarthria, dysphasia, or facial palsy. Initially, recurrent cerebral ischemia was diagnosed.
MR scans of the brain (GE healthcare, Signa HDxt 1.5 T) were obtained on the same day; the scans showed an old infarct in the left putamen with hyperintensity on fluid-attenuated inversion recovery (FLAIR), T2-weighted imaging (T2WI), and the ADC map (Fig. 1), which was consistent with the patient’s recent stroke history. However, MRI revealed an additional high signal intensity on DWI and low signal intensity on the ADC map in the left SN and globus pallidus, which were suggestive of acute cytotoxic edema (Fig. 2). Moreover, hyperintensity was also observed in the same regions on FLAIR/T2WI, findings that are unusual for acute ischemic stroke. Because the left SN was outside the middle cerebral arterial territory, the findings were most compatible with a diagnosis of acute pallidonigral injury secondary to striatal infarction. The patient received conservative treatment and gradually recovered right-lower-limb strength over a 1-month period.
Discussion and conclusions
Secondary pallidonigral degeneration outside the middle cerebral artery (MCA) territory after an ipsilateral MCA territory infarct has been reported in previous studies using conventional MRI at later stages [4,5,6]. Such TNDs, which include focal neuronal death, gliosis, and axonal degeneration in chronic cases, mainly occur some weeks after the primary onset of stroke and may be mistaken for a new episode of cerebral infarction. This is particularly true when ischemic-sensitive DWI is used in routine stroke protocol because similar DWI water-restriction findings in the TND may mislead the clinical physician, as reported in our case. Delayed hyperintense lesions in the ipsilateral SN involving the striatal structure could also occur without overt clinical symptomatology even at a later stage or after the development of ischemic lesions . The clinical manifestation in patients with secondary pallidonigral degeneration has not been well elucidated in previous reports. Our case is the first report of secondary pallidonigral degeneration manifested as stroke mimics.
SN is a vulnerable central nervous system structure that is vulnerable to injury caused by secondary degeneration. Previous reports have shown neuronal loss in the compact zone of the SN after massive unilateral basal ganglia infarction . This type of insult has been attributed to excessive excitation of the postsynaptic deep nuclei due to the loss of trans-synaptic γ-aminobutyric acid (GABA-)ergic inputs, which mediate the striatonigral pathway [6, 7]. In our patient, the observed cytotoxic edema in the pallidum and SN, as shown in DWI, were likely due to axonal intramyelinic swelling or astrocytic swelling [8, 9], a result of disinhibition of the striatonigral GABAergic pathway. The local increase in fluid accumulation within the inter-myelinic layers could also be the underlying cause of MR signal changes on FLAIR/T2WI at acute setting.
In an acute setting, in contrast to ischemia-sensitive DWI, computed tomography incompletely depicts TND. MRI provides accurate anatomical and pathological information regarding primary brain injury and associated secondary lesions. A complete MRI protocol for cerebral stroke, including T1-weighted images, T2-weighted images, T2 FLAIR, DWI, and MRI angiography, not only provides sensitive and specific signal intensity changes in the primary infarcted site but also distinguishes old infarcts from secondary neuronal degeneration. In summary, secondary striatonigral degeneration may mimic recurrent stroke clinically and radiologically. Understanding this nonischemic and excitotoxicity-induced injury can prevent administration of unnecessary treatment to patients.
Saji M, Reis DJ. Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist. Science. 1987;235(4784):66–9.
Winter B, Brunecker P, Fiebach JB, Jungehulsing GJ, Kronenberg G, Endres M. Striatal infarction elicits secondary extrafocal MRI changes in ipsilateral substantia nigra. PLoS One. 2015;10(9):e0136483.
Kinoshita T, Moritani T, Shrier DA, Wang HZ, Hiwatashi A, Numaguchi Y, Westesson PL. Secondary degeneration of the substantia nigra and corticospinal tract after hemorrhagic middle cerebral artery infarction: diffusion-weighted MR findings. Magn Reson Med Sci. 2002;1(3):175–8.
Zhang J, Zhang Y, Xing S, Liang Z, Zeng J. Secondary neurodegeneration in remote regions after focal cerebral infarction. Stroke. 2012;43:1700–5.
Ogawa T, Yoshida Y, Okudera T, Noguchi K, Kado H, Uemura K. Secondary thalamic degeneration after cerebral infarction in the middle cerebral artery distribution: evaluation with MR imaging. Radiology. 1997;204:255–62.
Ogawa T, Okudera T, Inugami A, Noguchi K, Kado H, Yoshida Y, et al. Degeneration of the ipsilateral substantia nigra after striatal infarction: evaluation with MR imaging. Radiology. 1997;204:847–51.
Nakane M, Teraoka A, Asato R, et al. Degeneration of ipsilateral substantia nigra following cerebral infarction in the striatum. Stroke. 1992;23:328–32.
Moritani T, Smoker WRK, Sato Y, et al. Diffusion weighted imaging of acute excitotoxic brain injury. AJNR Am J Neuroradiol. 2005;26:216–28.
Nakajima M, Inatomi Y, Okigawa T, et al. Secondary signal change and an apparent diffusion coefficient decrease of the substantia nigra after striatal infarction. Stroke. 2013;44(1):213–6.
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The study protocol was approved by the Institutional Review Board of Taipei Medical University Hospital.
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Tsai, RJ., Hsieh, LC., Cheng, SJ. et al. Secondary pallidonigral degeneration mimicking recurrent acute stroke in clinical presentation and magnetic resonance imaging: a case report. BMC Neurol 17, 215 (2017). https://doi.org/10.1186/s12883-017-1000-5