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Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia

Abstract

Background

Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia.

Methods

We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms.

Results

Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. The median score of ESS was 9 (IQR = 5–12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. A high EDSS score significantly associated with a Hoehn & Yahr score > 4 (p = 0.02).

Conclusions

In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

Background

The NMS of PD are frequent and can be very disabling [1, 2].

Sleep disorders associated with PD are one of the most common NMS and have been reported in 38 to 98% of PD patients [3]. They were first mentioned by James Parkinson himself in his famous monograph about the disease. Sleep disorders can occur before the diagnosis of PD, but become more severe and frequent as the disease stage progresses [2].

Patients with PD are at a greater risk for developing sleep disturbances than the general population. Sleep disturbances are a common but often under recognized feature of PD in clinical practice because of the absence of systematic or specific questioning by health care professionals [4].

There have been limited recent studies published on PD in sub Saharan Africa [5,6,7,8,9,10,11,12] and far fewer from Ethiopia [13, 14]. Poor sleep quality has been found to be strongly associated with poverty and race [15] and yet there have been no published data on sleep disorders in people with PD living in sub Saharan Africa. We wanted to document the prevalence of sleep disorders and their determinant factors in people living with PD in Ethiopia.

Methods

We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient departments in Tikur Anbessa and Zewuditu Memorial Hospitals in Addis Ababa University. These serve as the hospitals for the only neurology training center in Ethiopia. Inclusion criteria were patients ≥18 years old diagnosed with PD using the UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria seen at the two referral hospitals during the study period who gave informed verbal consent for study participation. Exclusion criteria were secondary Parkinsonism or refusal of informed verbal consent. Demographic data, clinical history and physical examination findings were collected from participants using structured questionnaires in Amharic and English. We also used two data collection instruments: the Parkinson Disease Sleep Scale version- 2 (PDSS-2) [16], and the Epworth Sleepiness Scale (ESS) [17, 18].

The PDSS-2 is a scale addressing 15 commonly reported symptoms associated with sleep disturbance. This scale has been shown to correlate with the Parkinson’s disease Quality of Life Questionnaire (PDQ-39), the Unified Parkinson’s Disease Rating Scale motor scores (UPDRS-III), and the Clinical Global Impressions Severity Score (CGI Item 1) [19,20,21].

The ESS is used as a subjective measure of a patient’s daytime sleepiness. This scale has a list of eight situations in which patients rate their likelihood of becoming sleepy on a scale of 0–3. Total score ranges from 0 to 24. A score of 10–15 suggests possible excessive daytime somnolence, and a score of 16–24 suggests definite excessive daytime somnolence [17, 18].

The PDSS-2 and ESS were translated from English into Amharic and pilot-tested on 10 subjects. All subjects understood every question without difficulty. No re-translation was required. These subjects were not included in the study results.

Analysis was performed using SPSS/PC version 20.0 software packages for statistical analysis (SPSS). Descriptive summaries were employed to describe socio-demographic and clinical characteristics. Appropriate measures of central tendency, frequency distribution, cross tabulation, Fisher’s Exact test and binary logistic regression analysis were conducted. Odds ratios and 95% confidence intervals were calculated. A p value less than 0.05 was considered a statistically significant association between assessed variables.

Protocol approvals were obtained from the ethical review Committee of the Department of Neurology and the Institutional Review Board and Research and Publication Committee of the College of Health Sciences of Addis Ababa University. Informed patient consent was obtained verbally before study enrollment. Patient data was deidentified during subsequent analysis and dissemination.

Results

Out of 158 patients who presented during the study period, two refused consent and one did not fulfill the diagnostic criteria. A total of 155 subjects were included in this study: 127 (81.9%) male: 28 (18.1%) female. Table 1 shows the demographics of our subjects. The mean duration of symptoms, duration since PD diagnosis and duration of PD treatment were 6.37, 4.90, 4.68 yrs. respectively. All patients were taking levodopa and 23.9% were taking trihexyphenidyl. No patient was taking other anti-parkinsonian agents (e.g. dopamine agonist, amantadine).

Table 1 Socio-demographic Factors

Table 2 shows the results of the PDSS-2 scores. No patient had a score of zero (range 4–39). The median score was 17 (IQR 11–24). Overall, 66/155 (42.6%) reported not having slept well > 2 days per week. 68/155 (43.9%) scored > 18. The most frequent sleep problems (defined as > 2 nights per week) were due to nocturia (73.5%), followed by difficulty with mobility in bed (37.4%), distressing dreams (36.1%) and sleep maintenance insomnia (34.8%).

Table 2 Results of Parkinson Disease Sleep Scale Version 2

Univariate analysis was performed to determine factors associated with a PDSS-2 score > 18. A previous history of sleep disturbance before PD motor symptoms (OR 3.54; 95% CI 1.61–7.76, p = 0.001) and unemployment (OR 2.27; 95% CI 1.07–4.79, p = 0.023) both associated with a high PDSS-2 score. However a logistic regression analysis didn’t show a significant association with a previous history of sleep disturbance, age, gender, levodopa or trihexyphenidyl use, marital, educational or employment status.

The results of the ESS are shown in the Fig. 1. The median score was 9 (IQR 5–12). 73/155 (47.1%) of the patients had possible or definite excessive daytime somnolence. An EDSS score of > 10 associated with an H&Y score > 4 (p = 0.02). There was no statistically significant association between age, gender, PD duration, levodopa or trihexyphenidyl use, marital status, educational status or employment status with daytime sleepiness (EDSS score > 10).

Fig. 1
figure 1

Frequency distribution of total Epworth sleepiness scale (ESS) scores*

On univariate analysis, there was a statistically significant association between ESS total score > 10 with only two variables of the PDSS-2: PD patients waking up at night due to snoring or difficulties with breathing (OR 2.87; 95% CI 1.25–6.60, p = 0.015) and getting up at night to pass urine (OR 2.3; 95% CI 1.08–4.92, p = 0.042). The other items of the PDSS-2 were not associated with a high ESS score.

Discussion

We found that all of our Ethiopian PD patients reported some sleep problem, with a large minority (42.6%) reporting not sleeping well > 2 nights per week. One community based study from Norway reported that 60% of their PD patients had sleep problems [22].

Compared to patients from Germany [23] and the United Kingdom [24] in terms of overall sleep disturbance, there was a higher percentage of Ethiopian patients with a severe sleep disorder. Trenkwalder et al. [16] reported a mean PDSS score of 16.5- similarly to our mean score of 18.3 (median 17). However, they found that only 6.3% of their patients had a score > 30, whereas in our population, 23.2% of our patients had a score > 30 [16].

Nocturia and mobility difficulties were the most frequent sleep problems in our population. Other authors have found similar issues. Nocturia was reported by 62% of patients in the NMS Quest Study [25]. Adler et al. reported that 80% of patients with PD have two or more episodes of nocturia per night, and 33% urinate at least three times per night [26]. Lees and his colleagues [24] have reported nocturnal disturbances in 215 of 220 PD patients, including nocturia (79%) and difficulty turning over in bed (65%).

Over a third of our patients (36.1%) reported having distressing dreams. Nightmares have been reported in 30% of patients with PD and are correlated with disease severity and levodopa dose [27].

Insomnia occurs in about 30% of patients with PD. [27] Patients often develop a sleep pattern marked by excessive napping during the day and wakefulness at night [2]. We found sleep onset insomnia ≥2 days/week in 47 PD patients (30.3%) and sleep maintenance insomnia ≥2 days/week in 54 PD patients (34.9%). This is comparable with one study from India. Kumar et al. reported the prevalence of insomnia in PD patients were 30% [27].

Excessive day-time sleepiness (EDS) is a common complaint of patients with PD. [28, 29] It can occur early in PD [30], and may predate the diagnosis [31]. We found that 47.1% of our patients had possible or definite EDS. This is one of the highest rates reported in the world. Possible or definite EDS (ESS > 10) was seen in 15.5% of PD patients in Norway, 33% in Austria, 40.6% in New York USA, 46.2% in France, and 50.2% in Houston,USA [3, 32,33,34,35]. Adler et al. identified that advanced disease stage and age predicted EDS [26]. We also found an association between higher PD stage and higher ESS scores.

The number of patients using trihexyphenidyl is high (23.9%) in our study. This drug is not commonly used in western countries. However, due to cost, levodopa/carbidopa and trihexyphenidyl are the only available medications to treat PD symptoms. Therefore, trihexyphenidyl is often the first medication prescribed. Although its anticholinergic property may affect sleep, we did not find an association between trihexyphenidyl use and a higher level of sleep disturbance.

We found that high ESS scores associated with patients reporting both nocturia and breathing difficulties/snoring on the PDSS. OSA is defined as intermittently absent or reduced airflow during sleep despite respiratory effort. A study from Mexico City on 120 PD patients reported obstructive sleep apnea (OSA) in 39% of patients [36]. We found 57 PD patients (36.8%) reporting OSA symptoms at least 1 day per week. A study from France on 100 patients also reported 27% of PD patents were having obstructive sleep apnea [37].

One limitation of our study is that we did not assess body mass index (BMI) in our patients. High BMI is a major contributor of OSA. However, the prevalence of obesity in Ethiopia is very low. A World Bank report in June 2017 estimated the prevalence of obesity in Ethiopia to be less than 5% [38]. This was much lower than the other countries [38]. A summary report on risk factors for non-communicable diseases in Ethiopia from 2016 reported the prevalence of obesity (BMI > 30) for male and female Ethiopians was 0.5 and 2% respectively [39]. Another study from 2011 estimated the prevalence of obesity to be 2.1% for males and 10.2% for females. Although this study reported a higher rate among females than the others, this rate is still low, and most of our PD patients were male [40].

Another limitation of our study was that we did not assess for anxiety/depression. One study found an association between depression and sleep disorders [3], while others did not assess for depression or found no association [16, 23, 24, 31,32,33,34]. There is no validated depression scale for PD patients in Ethiopia, so we felt this was out of scope for this study.

Our study had other limitations. In Ethiopia there is no polysomnography (PSG), the gold standard for evaluating sleep disorders. Therefore, we had to rely on the PDSS-2. The PDSS is a subjective semi quantitative scale, which attempts to provide a holistic and clinical assessment of the complex etiology of sleep problems in Parkinson’s disease.

One other significant limitation of our study was our inability to assess for REM Sleep Behavior Disorder (RBD). Only 15 (9.7%) of our patients attended their clinic visits with a reliable sleep partner, so we could not use a questionnaire to evaluate for RBD, and of course, did not have access to PSG. In one study of 19 patients with PD, 47% met the diagnostic criteria of RBD based on PSG recordings, but only 33% of these cases were detected by a questionnaire [26]. We suspect that our percent of patients with Sleep Disorders would have been higher had we had a reliable way to assess for RBD.

Conclusions

We found a higher percentage of Ethiopian patients with a high PDSS-2 score (> 18) than reported in other populations. Our patients also had one of the highest rates of EDS in the world. We cannot conclude from our data that this is due to poverty, but further investigation into this question is warranted.

Availability of data and materials

The data is on a password protected computer of Dr. DM. The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.

Abbreviations

CI:

Confidence Interval

EDS:

Excessive Daytime Sleepiness

ESS:

Epworth Sleepiness Scale

IQR:

Inter Quartile Range

NMS:

Non Motor Symptoms

PD:

Parkinson ‘s Disease

PDSS-2:

Parkinson’s Disease Sleep Scale Version 2

References

  1. Parkinson J. An essay on the shaking palsy (London, 1817). J Neuropsychiatry Clin Neurosci. 2002;14(2):223-36. discussion 222.

    Article  Google Scholar 

  2. Zesiewicz T, Hauser R. Medical treatment of motor and nonmotor features of parkinson’s disease. Continuum:Lifelong Learning Neurol. 2007;13(1):12–38.

    Google Scholar 

  3. Tandberg E, Larsen J, Karlsen K. Excessive daytime sleepiness and sleep benefit in Parkinson’s disease: A community-based study. Mov Disord. 1999;14:922–7.

    Article  CAS  PubMed  Google Scholar 

  4. Dhawan V, Healy DG, Pal S, Chaudhuri KR. Sleep-related problems of Parkinson’s disease. Age Aging. 2006;35:220–8.

    Article  CAS  Google Scholar 

  5. Dotchin CL, Msuya O, Kissima J, Massawe J, Mhina A, Moshi A, Aris E, Jusabani A, Whiting D, Masuki G, Walker RW. The prevalence of Parkinson’s disease in rural Tanzania. Mov Disord. 2008;23(11):1567–72.

    Article  PubMed  Google Scholar 

  6. Dotchin C, Jusabani A, Walker R. Three year follow up of levodopa treatment in a prevalent cohort of patients with Parkinson’s disease in Hai. Tanzania J Neurol. 2011;258(9):1649–56.

    Article  CAS  PubMed  Google Scholar 

  7. Mshana G, Dotchin CL, Walker RW. “We call it the shaking illness”: perceptions and experiences of Parkinson’s disease in rural northern Tanzania. BMC Public Health. 2011;11:219.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Okubadejo NU, Bower JH, Rocca WA, Maraganore DM. Parkinson’s disease in Africa: a systematic review of epidemiological and genetic studies. Mov Disord. 2006;21(12):2150–6.

    Article  PubMed  Google Scholar 

  9. Rochester L, Rafferty D, Dotchin C, Msuya O, Minde V, Walker R. Rehabilitation in Parkinson’s disease: the effect of cueing therapy on single and dual-task gait in a drug naïve population in the Hai district of northern Tanzania. Mov Disord. 2010;25(7):906–11.

    Article  PubMed  Google Scholar 

  10. Akinyemi R. Epidemiology of parkinsonism and Parkinson's disease in sub-Saharan Africa: Nigerian profile. J Neurosci Rural Pract. 2012;3(3):233–4.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Okubadejo NU, Ojo OO, Oshinaike OO. Clinical profile of parkinsonism and Parkinson's disease in Lagos. Southwestern Nigeria BMC Neurol. 2010;10:1.

    Article  PubMed  Google Scholar 

  12. Akinyemi RO, Okubadejo NU, Akinyemi JO, Owolabi MO, Owolabi LF, Ogunniyi A. Cognitive dysfunction in Nigerians with Parkinson's disease. MovDisord. 2008;23:1378–83.

    Google Scholar 

  13. Haimanot R. Parkinsons disease in Ethiopia - a prospective study of 70 patients. East Afican Med J. 1985;62(8):571–9.

    CAS  Google Scholar 

  14. Bower J, Teshome M, Melaku Z, Zenebe G. Frequency of movement disorders in an Ethiopian University practice. Mov Disord. 2005;20:1209–13.

    Article  PubMed  Google Scholar 

  15. Patel NP, Grandner MA, Xie D, Branas CC, Gooneratne N. "sleep disparity" in the population: poor sleep quality is strongly associated with poverty and ethnicity. BMC Public Helath. 2010;10:475.

    Article  Google Scholar 

  16. Trenkwalder C, Kohnen R, Högl B. Parkinson’s disease sleep scale-validation of the revised version PDSS-2. Mov Disord. 2011;26(4):644–52.

    Article  PubMed  Google Scholar 

  17. Johans MW. A new method for measuring daytime sleepiness: Epworth Sleepiness Scale (ESS). Am Sleep Med. 1991;14(6):540–5.

    Google Scholar 

  18. Kumar S, Bhatia M, Behari M. Excessive day time sleepiness in Parkinson’s disease as assessed by Epworth sleepiness scale (ESS). Sleep Med. 2003;4:339–42.

    Article  PubMed  Google Scholar 

  19. Hagell P, Nilsson M. The 39-item Parkinson’s Disease Questionnaire (PDQ-39). Ther Adv Neurol Disord. 2009;2(4):205–14.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Fahn S, Elton RL. UPDRS program members. Unified Parkinsons disease rating scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB, editors. Recent developments in Parkinsons disease, vol. 2. Florham Park: Macmillan Healthcare Information; 1987. p. 153–63.

    Google Scholar 

  21. Chaudhuri KR, Pal S, Di Marco A, Whately-Smith C, Bridgman K, Mathew R, Pezzela FR, Forbes A, Högl B, Trenkwalder C. The Parkinson’s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73:629–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Tandberg E, Larsen JP, Karlsen KH. A community-based study of sleep disorders in patients with Parkinson disease. Mov Disord. 1990;5:28–285.

    Google Scholar 

  23. Smith MC, Ellgring H, Oertel WH. Sleep disturbances in Parkinson's disease patients and spouses. J Am Geriatric Soc. 1997 Feb;45(2):194–9.

    Article  CAS  Google Scholar 

  24. Lees AJ, Blackburn NA, Campbell VL. The nighttime problems of Parkinson’s disease. Clin Neuropharmacol. 1988;11(6):512–9.

    Article  CAS  PubMed  Google Scholar 

  25. Martinez-Martin P, Schapira A, Stocchi F, Sethi K, Odin P, MacPhee G, et al. Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting: study using nonmotor symptoms questionnaire in 545 patients. MovDisord. 2007;22:1623–9.

    Google Scholar 

  26. Adler CH, Thorpy MJ. Neurology. 2005;64(Suppl 3):S12–20.

    Article  PubMed  Google Scholar 

  27. Kumar S, Bhatia M, Behari M. Sleep disorders in Parkinson’s disease. MovDisord. 2002;17:775–81.

    Google Scholar 

  28. Chaudhuri K. Nocturnal symptom complex in PD and its management. Neurology. 2003;61(Suppl. 3):S17–23.

    Article  CAS  PubMed  Google Scholar 

  29. Garcia-Borreguero D, Larosa O, Bravo M. Parkinson’s disease and sleep. Sleep Med Rev. 2003;7:115–29.

    Article  PubMed  Google Scholar 

  30. Fabrbrini G, Barbanti P, et al. CAe Excessive daytime sleepiness in de novo and treated Parkinson’s disease Mov Disord 2002;17:1026–1030.

  31. Abbott R, Ross G, White L. Excessive daytime sleepiness and the future risk of Parkinson’s disease. MovDisord. 2005;20(Suppl. 10):S101 (P 341).

    Google Scholar 

  32. Hogl B, Seppi K, Brandauer E, Glazl S, Frauscher B et al. Increased daytime sleepiness in Parkinson's disease: a questionnaire survey. MovDisord 2003 18(3): 319–323.

    Article  Google Scholar 

  33. Brodsky MA, Godbold J, Roth T, Olanow CW. Sleepiness in Parkinson's disease:a controlled study. MovDisord. 2003;18(6):668–72.

    Google Scholar 

  34. De Cock VC, Bayard S, Jaussent I, Charif M, Grini M, et al. Daytime sleepiness in PArkinon's disease: a reappraisal. PLoS One. 2014;9(9):e107278.

    Article  Google Scholar 

  35. Ondo WG, DAt Vuong K, Khan H, Atassi F, Kwak C, Jancovic J. Daytime sleepiness and other sleep disorders in PArkinson's disease. Neurology 2001 57(8):1302–1306.

    Article  CAS  PubMed  Google Scholar 

  36. Vanessa A, Mayela R, Azyadeh C, et al. Prevalence and correlates of sleep disorders in parkinson's disease. ArqNeuropsiquiartr. 2015;73903:241–5.

    Google Scholar 

  37. Val'erie C, Mahar A, Samaranda L, et al. Is obstructive sleep apnea a problem in parkinson's disease. Sleep Med. 2010;11:247–2520.

  38. Htenas AM, Tanimichi-Hoberg Y, Brown L. An overview of links between obesity and food systems: implications for the agriculture GP agenda (English). Washington, DC: World Bank Group; 2017. http://documents.worldbank.org/curated/en/222101499437276873.

  39. Ethiopian Public Health Institute in collaboration with World Health Organization. A summary report on STEPs survey on risk factors for non-communicable disease and prevalence of selected NCDs in Ethiopia. Addis Ababa; 2016. http://www.gov.

  40. Tran A, Gelaye B, Girma B, et al. Prevalence of Metabolic Syndrome among Working Adults in Ethiopia, AGE-Hindawi Access to Research. Int J Hypertens. 2011:8.

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Acknowledgments

Not applicable.

Funding

This study was supported by the Department of Neurology, Addis Ababa University School of Medicine. It did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Contributions

Dr. DM data acquisition, analysis, interpretation, review and critique. Dr. AT analysis, interpretation, review and critique. Dr. JHB analysis, interpretation, review and critique. Dr. DA analysis, interpretation, review and critique. Dr. DM also participated in project execution and writing first draft on manuscript preparation. All authors’ read and approved the final version of the manuscript.

Corresponding author

Correspondence to Dereje Melka.

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Ethics approval and consent to participate

Protocol approvals were obtained from the ethical review Committee of the Department of Neurology and the Institutional Review Board and Research and Publication Committee of the College of Health Sciences of Addis Ababa University. Informed patient consent was obtained verbally before study enrollment, which was approved by both the Department of Neurology and the Institutional Review Board and Research and Publication Committee of the College of Health Sciences. Patient data was deidentified during subsequent analysis and dissemination.

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Melka, D., Tafesse, A., Bower, J.H. et al. Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia. BMC Neurol 19, 205 (2019). https://doi.org/10.1186/s12883-019-1431-2

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