Skip to main content

Myotonic dystrophy type 1 accompanied with normal pressure hydrocephalus: a case report and literature review

Abstract

Background

Myotonic dystrophy type 1 (DM1) is the most common disease that can cause muscle weakness and atrophy among adults. Normal pressure hydrocephalus (NPH) is characterized by the triad of gait disturbance, cognitive impairment and urinary incontinence. The association between DM1 and NPH is extremely rare. We report a Chinese female patient with DM1 in association with NPH.

Case presentation

The patient presented with a history of 3-year of walking instability and cognitive impairment. Her brain MRI showed ventriculomegaly with normal cerebrospinal fluid (CSF) pressure and the CSF tap-test was positive, which indicated the diagnosis of probable NPH. DM1 was confirmed by genetic testing.

Conclusions

Four patients with DM1-NPH association were found before. The association between NPH and DM1 may not be just a coincidence, NPH may occur in DM1 later in life and it is vital to recognize the association as a shunt surgery may improve patients’ quality of life.

Peer Review reports

Background

Myotonic dystrophy type 1 (DM1) is the most common type of muscular dystrophy in adult. It is an autosome dominant disease which is associated with abnormal expansion of the repeated cytosine-thymine-guanine (CTG) in the 3′-untranslated regions in dystrophia myotonica-protein kinase (DMPK) gene on chromosome 19q13.3 [1]. In DM1, CTG invariably repeats for over 50 times. The disease can occur from infants to adults with the mean age of onset being in the third decade of life [2]. While the symptoms of DM1 are polymorphous [3, 4], myotonia and muscular weakness are typical clinical features, primarily affecting facial and distal limb muscles. DM1 can involve multiple systems, such as cataracts, gastrointestinal symptoms, cardiac conduction defects, hypogonadism, endocrine function impairment, and brain abnormalities [1, 5, 6]. In addition, expectation of life is markedly decreased, primarily due to aspiration pneumonia or cardiac arrhythmias [7, 8].

Normal pressure hydrocephalus (NPH) is a neurological disease characterized by the triad of gait disturbance, cognitive impairment and urinary incontinence, presenting ventriculomegaly and normal cerebrospinal fluid (CSF) pressure. It was initially described in 1965 and can be treated via ventriculoperitoneal shunt surgery [9,10,11]. The prevalence of probable NPH was 0.2% in people aged 70–79 years and 5.9% in those aged 80 years and older [12]. According to the American-European NPH guidelines [13], NPH can be classified into probable, possible, and unlikely categories. Probable NPH is diagnosed by hydrocephalic ventricular enlargement together with gait disturbance and either cognitive impairment or urinary incontinence.

The coexistence of myotonic dystrophy (DM) and NPH has been reported in four patients so far (Table 1) [14,15,16]. But none of them were confirmed by genetic testing or muscular biopsy. Here, we present a Chinese female patient with DM1 confirmed by genetic testing in association with NPH and conduct a review of the literature in order to determine clinical specific features of this co-occurrence and the possible mechanisms.

Table 1 Summary of five cases associating myotonic dystrophy (DM) and normal pressure hydrocephalus (NPH)

Case presentation

A 65-year-old Chinese woman with 1 year of grade school education came to the Department of Neurology, First Affiliated Hospital of Zhejiang University in November 2018. Her complaints included a 3-year history of walking instability which was characterized by slow walking, lower foot height, hypsokinesis, poor balance, reduced stride length, broad-based gait, and difficult starting/turning. Furthermore, she was found to have memory loss and was slow to respond. The symptoms had gradually worsened, and she was dependent on family members to help her walk. Twenty days before presenting to our clinic, she suffered thoracic vertebral compression fracture (T11–12) due to a fall at home and required surgery. The patient had no medical history of hypertension, diabetes, cardiac diseases. She had no family history of similar diseases. Her neurological examination revealed a severe gait disturbance and increased muscular tone of limbs. Marked muscle wasting was seen in the temporalis. The Medical Research Council power was 4/5 on the flexor and extensor of four limbs (Fig. 1a-c). Neuropsychological examination revealed diminished memory, prominent math difficulties and temporal-space disorientation. She scored 7/30 on the MMSE (Table 2). No abnormalities in the cranial nerves and sensory system were noted.

Fig. 1
figure1

a Atrophy of temporalis. b Atrophy of bilateral distal upper limbs. c Atrophy of bilateral distal lower limbs. d Evans index = 0.34, indicating ventricular enlargement. e&f MRI scans showed atrophy on bilateral frontal, temporal and occipital lobes. g DNA analysis indicated that CTG repeated over 100 times

Table 2 Results of MMSE

Additional screens detected no abnormalities, including normal routine blood tests, biochemistry examination, coagulation function, thyroid function, tumor marker, and normal folate and vitamin B12 levels. Screens for HIV, syphilis and hepatitis were negative. Furthermore, routine CSF analysis, CSF biochemistry and CSF pressure were normal. However, first degree atrioventricular block and complete right bundle branch block was presented in the electrocardiogram (ECG), cholecystolithiasis in abdominal ultrasound, bilateral multiple thyroid nodules in the thyroid ultrasound, and chronic inflammatory foci in the lower lobes of both lungs in lung CT. Furthermore, brain MRI revealed ventriculomegaly (Evans index =0.34) (Fig. 1d) and atrophy on bilateral frontal, temporal and occipital lobes (Fig. 1e-f). Moreover, the electromyogram (EMG) indicated muscle damage with excessive myotonic discharge. Finally, genetic testing showed an over 100 CTG repeat expansion in the DMPK gene on chromosome 19q13.3, confirming the diagnosis of DM1 (Fig. 1g). Her two children also underwent genetic testing and one daughter presented with a repeat expansion on the DMPK gene.

As noted previously,the patient demonstrated gait disturbance and cognitive impairment (in absence of urinary incontinence) accompanying with normal CSF pressure and ventricular enlargement. These observations triggered a probably case of NPH [17] and cerebrospinal fluid tap-test (CSF-TT) was performed. The patient’s gait temporarily improved after CSF drainage (Table 3). A second CSF-TT was performed with a similar pattern of temporary gait improvements (Table 3). These observations are consistent with NPH, further suggesting the diagnosis of NPH. However, the patient refused shunt surgery and was discharged. A 6-month follow-up showed aggravation of symptoms and increased dependence on family members.

Table 3 Results of cerebrospinal fluid tap-test by using 10-m walking test

Discussion and conclusions

Currently, the definite diagnosis of DM1 is made by DNA analysis. By contrast, in the past, non-molecular testing has been widely adopted which plays no role now [18] due to its inaccuracy. We searched Pubmed (index 1965–2016) for similar cases. An association between NPH and DM1 has been noted in 4 other cases, (Table 1) [14,15,16]. although no definitive genetic testing for DM1 was conducted in previous case studies. Here we describe a case with genetically confirmed DM1 and NPH.

Genetic testing showed that the patient had 100 CTG repeats in the DMPK gene. Consistent with a clinical presentation of DM1, the patient exhibited muscular weakness, muscle wasting of temporal and distal limb muscles. Additionally, myogenic damage and excessive myotonic discharge were noted on the EMG. For the last 3 years, she had experienced progressive gait disturbance and cognitive decline. Brain MRI showed enlarged ventricles with an Evans index of 0.34 and CSF pressure was normal. Ventricular enlargement in the presence of normal CSF pressure pointed to NPH [17], which was supported by two positive CSF-TT. NPH can be confirmed with ventriculoperitoneal shunting, unfortunately, our patient refused treatment.

DM1 brains show general atrophy and widespread gray matter volume reductions [19]. It is well established that DM1 affected central nervous system including cognitive and psychiatric dysfunction [20,21,22,23,24,25,26,27,28,29,30]. Deficits in several cognitive domains have been reported, including: executive function, memory, visuospatial problems, processing speed and attention [20,21,22,23,24,25].. These deficits appear to worsen as patient’s age. For instance, Sansone et al. [22] found frontal cognitive impairment worsens over time and two recent longitudinal studies have observed a progression of cognitive impairment, particularly in verbal memory, visuospatial function, attention and processing speed [31, 32]. However, the degree of decline has no correlation with the repetition number of CTG or the severity of muscular involvement [21, 31, 32]. In addition to cognitive impairments, several studies have described psychiatric disturbances in DM1 patients such as anxiety, depression, apathy, anosognosia, paranoid and aggressive traits in DM1 [20, 26,27,28,29,30, 33, 34]. Several psychiatric disorders such as anxiety are negatively correlated with level of education and the number of CTG repeats [30].

Cerebral ventriculomegaly is commonly reported in DM1 patients [35,36,37] and appears to be progressive [35]. Glantz et al. [36] reported an increased incidence (71.4%) of ventriculomegaly in DM1 patients. Neuroimaging studies using DTI and VBM have revealed extensive white and gray matter damage among DM1 patients. Brain abnormalities have been linked with the number of CTG repeats, cognitive function and muscle weakness [38,39,40,41,42,43,44,45,46,47].

The mechanism of NPH may be the obliteration of arachnoid villi (small protrusions of the arachnoid mater which can return CSF to the venous circulation), leading to the disturbances of CSF reabsorption, leading to disrupted CSF reabsorption and subsequent ventricular enlargement [48, 49]. The possible mechanism of NPH in DM1 patients may be related to widespread cell membrane defects caused by genetic abnormalities [14], leading to the arachnoid granulations [48, 50, 51]. However, the association between DM1 and NPH can be overlooked for several reasons. One might be NPH tends to occur in elderly DM1 patients, and other reasons could be that cardinal symptoms of NPH, e.g. cognitive impairment, disturbance of gait and urinary incontinence, are common in the elderly and therefore ignored as nonspecific. Mathieu and Prevost found that the mean age at death was 55.4 years for the adult-onset phenotype of DM [7]. Furthermore, according to Smulders et al. [52], the survival rate of adult-onset type of DM1 who lives to the ages 25, 45 and 65 years is 99, 88 and 18%, in comparison to the expected survival rates for unaffected adults, which are99, 95 and 78%, respectively. Therefore, the probability of adult-onset DM1 patients living to 65 years of age is significantly reduced. Our patient is now 65 and patients with NPH in association with DM1 appear to be more than 50 years old (Table 1), suggesting DM1 may result in NPH later in life.

Two of the four patients with DM1-NPH association received shunt surgery (Table 1) and were markedly improved. Although our patient refused to be treated with ventriculoperitoneal shunt, her symptoms were ameliorated after CSF drainage (Table 3), also indicating that shunt surgery is an effective therapy.

Overall, for elderly patients with DM1 presenting symptoms of gait disturbance or urinary incontinence, it is vital to consider the association of NPH. Once DM1-NPH association is considered, shunt surgery should be suggested and the patient should be transferred to neurosurgery department. In this way, it could improve the patients’ quality of life.

Availability of data and materials

All data generated or analysed during this study are included in this published article.

Abbreviations

CSF:

Cerebrospinal fluid

CST-TT:

Cerebrospinal fluid tap-test

CTG:

Cytosine-thymine-guanine

DM1:

Myotonic dystrophy type 1

DMPK:

Dystrophia myotonica-protein kinase

ECG:

Electrocardiogram

EMG:

Electromyogram

MMSE:

Mini-Mental State Examination

NPH:

Normal pressure hydrocephalus

References

  1. 1.

    Udd B, Krahe R. The myotonic dystrophies: molecular, clinical, and therapeutic challenges. Lancet Neurol. 2012;11(10):891–905. https://doi.org/10.1016/S1474-4422(12)70204-1.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Heatwole C, Bode R, Johnson N, Quinn C, Martens W, McDermott MP, et al. Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1). Neurology. 2012;79(4):348–57. https://doi.org/10.1212/WNL.0b013e318260cbe6.

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Meola G. Myotonic dystrophies. Curr Opin Neurol. 2000;13(5):519–25.

    CAS  Article  Google Scholar 

  4. 4.

    Nagamitsu S, Ashizawa T. Myotonic dystrophies. Adv Neurol. 2002;88:293–314.

    CAS  PubMed  Google Scholar 

  5. 5.

    Portwood MM, Wicks JJ, Lieberman JS, Duveneck MJ. Intellectual and cognitive function in adults with myotonic muscular dystrophy. Arch Phys Med Rehabil. 1986;67(5):299–303.

    CAS  PubMed  Google Scholar 

  6. 6.

    Perini GI, Menegazzo E, Ermani M, Zara M, Gemma A, Ferruzza E, et al. Cognitive impairment and (CTG)n expansion in myotonic dystrophy patients. Biol Psychiatry. 1999;46(3):425–31.

    CAS  Article  Google Scholar 

  7. 7.

    Mathieu J, Allard P, Potvin L, Prevost C, Begin P. A 10-year study of mortality in a cohort of patients with myotonic dystrophy. Neurology. 1999;52(8):1658–62. https://doi.org/10.1212/wnl.52.8.1658.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Groh WJ, Groh MR, Saha C, Kincaid JC, Simmons Z, Ciafaloni E, et al. Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1. N Engl J Med. 2008;358(25):2688–97. https://doi.org/10.1056/NEJMoa062800.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Golz L, Ruppert FH, Meier U, Lemcke J. Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively. J Neurosurg. 2014;121(4):771–5. https://doi.org/10.3171/2014.6.JNS131211.

    Article  PubMed  Google Scholar 

  10. 10.

    Andren K, Wikkelso C, Tisell M, Hellstrom P. Natural course of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 2014;85(7):806–10. https://doi.org/10.1136/jnnp-2013-306117.

    Article  PubMed  Google Scholar 

  11. 11.

    Hakim S, Adams RD. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci. 1965;2(4):307–27.

    CAS  Article  Google Scholar 

  12. 12.

    Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelso C. Prevalence of idiopathic normal-pressure hydrocephalus. Neurology. 2014;82(16):1449–54. https://doi.org/10.1212/WNL.0000000000000342.

    Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57(3 Suppl):S4–16; discussion ii-v. https://doi.org/10.1227/01.neu.0000168185.29659.c5.

    Article  PubMed  Google Scholar 

  14. 14.

    Christensen PB. Normal pressure hydrocephalus in myotonic dystrophy. Eur Neurol. 1988;28(5):285–7. https://doi.org/10.1159/000116285.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Riggs JE, Rubenstein MN, Gutmann L. Myotonic dystrophy and normal-pressure hydrocephalus. Neurology. 1985;35(10):1535.

    CAS  Article  Google Scholar 

  16. 16.

    Delavallee M, Raftopoulos C. Normal pressure hydrocephalus in a patient with myotonic dystrophy: case report with a 10-year follow-up. Neurosurgery. 2006;58(4):E796; discussion E. https://doi.org/10.1227/01.NEU.0000204879.83077.C9.

    Article  PubMed  Google Scholar 

  17. 17.

    Graff-Radford NR. Normal pressure hydrocephalus. Neurol Clin. 2007;25(3):809–32, vii-viii. https://doi.org/10.1016/j.ncl.2007.03.004.

    Article  PubMed  Google Scholar 

  18. 18.

    Turner C, Hilton-Jones D. The myotonic dystrophies: diagnosis and management. J Neurol Neurosurg Psychiatry. 2010;81(4):358–67. https://doi.org/10.1136/jnnp.2008.158261.

    Article  PubMed  Google Scholar 

  19. 19.

    Okkersen K, Monckton DG, Le N, Tuladhar AM, Raaphorst J, van Engelen BGM. Brain imaging in myotonic dystrophy type 1 a systematic review. Neurology. 2017;89(9):960–9. https://doi.org/10.1212/Wnl.0000000000004300.

    Article  PubMed  Google Scholar 

  20. 20.

    Meola G, Sansone V. Cerebral involvement in myotonic dystrophies. Muscle Nerve. 2007;36(3):294–306. https://doi.org/10.1002/mus.20800.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Modoni A, Silvestri G, Pomponi MG, Mangiola F, Tonali PA, Marra C. Characterization of the pattern of cognitive impairment in myotonic dystrophy type 1. Arch Neurol. 2004;61(12):1943–7. https://doi.org/10.1001/archneur.61.12.1943.

    Article  PubMed  Google Scholar 

  22. 22.

    Sansone V, Gandossini S, Cotelli M, Calabria M, Zanetti O, Meola G. Cognitive impairment in adult myotonic dystrophies: a longitudinal study. Neurol Sci. 2007;28(1):9–15. https://doi.org/10.1007/s10072-007-0742-z.

    CAS  Article  PubMed  Google Scholar 

  23. 23.

    Winblad S, Lindberg C, Hansen S. Cognitive deficits and CTG repeat expansion size in classical myotonic dystrophy type 1 (DM1). Behav Brain Funct. 2006;2:16. https://doi.org/10.1186/1744-9081-2-16.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  24. 24.

    Baldanzi S, Cecchi P, Fabbri S, Pesaresi I, Simoncini C, Angelini C, et al. Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1. NeuroImage Clin. 2016;12:190–7. https://doi.org/10.1016/j.nicl.2016.06.011.

    Article  PubMed  PubMed Central  Google Scholar 

  25. 25.

    Callus E, Bertoldo EG, Beretta M, Boveri S, Cardani R, Fossati B, et al. Neuropsychological and psychological functioning aspects in Myotonic dystrophy type 1 patients in Italy. Front Neurol. 2018;9:751. https://doi.org/10.3389/fneur.2018.00751.

    Article  PubMed  PubMed Central  Google Scholar 

  26. 26.

    Gagnon C, Meola G, Hébert LJ, Puymirat J, Laberge L, Leone M. Report of the first outcome measures in Myotonic dystrophy type 1 (OMMYD-1) international workshop: Clearwater, Florida, November 30, 2011. Neuromuscul Disord. 2013;23(12):1056–68. https://doi.org/10.1016/j.nmd.2013.07.004.

    Article  PubMed  Google Scholar 

  27. 27.

    Rubinsztein JS, Rubinsztein DC, Goodburn S, Holland AJ. Apathy and hypersomnia are common features of myotonic dystrophy. J Neurol Neurosurg Psychiatry. 1998;64(4):510–5.

    CAS  Article  Google Scholar 

  28. 28.

    Peric S, Sreckov M, Basta I, Lavrnic D, Vujnic M, Marjanovic I, et al. Dependent and paranoid personality patterns in myotonic dystrophy type 1. Acta Neurol Scand. 2014;129(4):219–25. https://doi.org/10.1111/ane.12173.

    CAS  Article  PubMed  Google Scholar 

  29. 29.

    Baldanzi S, Bevilacqua F, Lorio R, Volpi L, Simoncini C, Petrucci A, et al. Disease awareness in myotonic dystrophy type 1: an observational cross-sectional study. Orphanet J Rare Dis. 2016;11:34. https://doi.org/10.1186/s13023-016-0417-z.

    Article  PubMed  PubMed Central  Google Scholar 

  30. 30.

    Bertrand JA, Jean S, Laberge L, Gagnon C, Mathieu J, Gagnon JF, et al. Psychological characteristics of patients with myotonic dystrophy type 1. Acta Neurol Scand. 2015;132(1):49–58. https://doi.org/10.1111/ane.12356.

    CAS  Article  PubMed  Google Scholar 

  31. 31.

    Gallais B, Gagnon C, Mathieu J, Richer L. Cognitive decline over time in adults with myotonic dystrophy type 1: a 9-year longitudinal study. Neuromuscul Disord. 2017;27(1):61–72.

    Article  Google Scholar 

  32. 32.

    Winblad S, Samuelsson L, Lindberg C, Meola G. Cognition in myotonic dystrophy type 1: a 5-year follow-up study. Eur J Neurol. 2016;23(9):1471–6. https://doi.org/10.1111/ene.13062.

    CAS  Article  PubMed  Google Scholar 

  33. 33.

    Winblad S, Jensen C, Månsson JE, Samuelsson L, Lindberg C. Depression in Myotonic dystrophy type 1: clinical and neuronal correlates. Behav Brain Funct. 2010;6:25. https://doi.org/10.1186/1744-9081-6-25.

    Article  PubMed  PubMed Central  Google Scholar 

  34. 34.

    Sistiaga A, Urreta I, Jodar M, Cobo AM, Emparanza J, Otaegui D, et al. Cognitive/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1. Psychol Med. 2010;40(3):487–95. https://doi.org/10.1017/s0033291709990602.

    CAS  Article  PubMed  Google Scholar 

  35. 35.

    Refsum S, Lonnum A, Sjaastad O, Engeset A. Dystrophia myotonica. Repeated pneumoencephalographic studies in ten patients. Neurology. 1967;17(4):345–8.

    CAS  Article  Google Scholar 

  36. 36.

    Glantz RH, Wright RB, Huckman MS, Garron DC, Siegel IM. Central nervous system magnetic resonance imaging findings in myotonic dystrophy. Arch Neurol. 1988;45(1):36–7.

    CAS  Article  Google Scholar 

  37. 37.

    Di Costanzo A, Di Salle F, Santoro L, Bonavita V, Tedeschi G. Brain MRI features of congenital- and adult-form myotonic dystrophy type 1: case-control study. Neuromusc Disord. 2002;12(5):476–83.

    Article  Google Scholar 

  38. 38.

    Antonini G, Mainero C, Romano A, Giubilei F, Ceschin V, Gragnani F, et al. Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study. J Neurol Neurosurg Psychiatry. 2004;75(11):1611–3.

    CAS  Article  Google Scholar 

  39. 39.

    Minnerop M, Weber B, Schoene-Bake JC, Roeske S, Mirbach S, Anspach C, et al. The brain in myotonic dystrophy 1 and 2: evidence for a predominant white matter disease. Brain. 2011;134(Pt 12):3530–46. https://doi.org/10.1093/brain/awr299.

    Article  PubMed  Google Scholar 

  40. 40.

    Caso F, Agosta F, Peric S, Rakočević-Stojanović V, Copetti M, Kostic VS, et al. Cognitive impairment in myotonic dystrophy type 1 is associated with white matter damage. PloS one. 2014;9(8):e104697. https://doi.org/10.1371/journal.pone.0104697.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  41. 41.

    Schneider-Gold C, Bellenberg B, Prehn C, Krogias C, Schneider R, Klein J, et al. Cortical and Subcortical Grey and White Matter Atrophy in Myotonic Dystrophies Type 1 and 2 Is Associated with Cognitive Impairment, Depression and Daytime Sleepiness. PloS one. 2015;10(6):e0130352. https://doi.org/10.1371/journal.pone.0130352.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  42. 42.

    Serra L, Petrucci A, Spanò B, Torso M, Olivito G, Lispi L, et al. How genetics affects the brain to produce higher-level dysfunctions in myotonic dystrophy type 1. Funct Neurol. 2015;30(1):21–31.

    PubMed  PubMed Central  Google Scholar 

  43. 43.

    Weber YG, Roebling R, Kassubek J, Hoffmann S, Rosenbohm A, Wolf M, et al. Comparative analysis of brain structure, metabolism, and cognition in myotonic dystrophy 1 and 2. Neurology. 2010;74(14):1108–17. https://doi.org/10.1212/WNL.0b013e3181d8c35f.

    CAS  Article  PubMed  Google Scholar 

  44. 44.

    Wozniak JR, Mueller BA, Bell CJ, Muetzel RL, Lim KO, Day JW. Diffusion tensor imaging reveals widespread white matter abnormalities in children and adolescents with myotonic dystrophy type 1. J Neurol. 2013;260(4):1122–31. https://doi.org/10.1007/s00415-012-6771-4.

    Article  PubMed  Google Scholar 

  45. 45.

    Wozniak JR, Mueller BA, Lim KO, Hemmy LS, Day JW. Tractography reveals diffuse white matter abnormalities in Myotonic dystrophy type 1. J Neurol Sci. 2014;341(1–2):73–8. https://doi.org/10.1016/j.jns.2014.04.005.

    Article  PubMed  PubMed Central  Google Scholar 

  46. 46.

    Wozniak JR, Mueller BA, Ward EE, Lim KO, Day JW. White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: a diffusion tensor imaging study. Neuromuscul Disord. 2011;21(2):89–96. https://doi.org/10.1016/j.nmd.2010.11.013.

    Article  PubMed  Google Scholar 

  47. 47.

    Zanigni S, Evangelisti S, Giannoccaro MP, Oppi F, Poda R, Giorgio A, et al. Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1. NeuroImage Clin. 2016;11:678–85.

    Article  Google Scholar 

  48. 48.

    Raftopoulos C, Chaskis C, Delecluse F, Cantraine F, Bidaut L, Brotchi J. Morphological quantitative analysis of intracranial pressure waves in normal pressure hydrocephalus. Neurol Res. 1992;14(5):389–96.

    CAS  Article  Google Scholar 

  49. 49.

    Raftopoulos C, Deleval J, Chaskis C, Leonard A, Cantraine F, Desmyttere F, et al. Cognitive recovery in idiopathic normal pressure hydrocephalus: a prospective study. Neurosurgery. 1994;35(3):397–404 discussion −5.

    CAS  Article  Google Scholar 

  50. 50.

    Duinkerke A, Williams MA, Rigamonti D, Hillis AE. Cognitive recovery in idiopathic normal pressure hydrocephalus after shunt. Cogn Behav Neurol. 2004;17(3):179–84.

    Article  Google Scholar 

  51. 51.

    Murakami Y, Matsumoto Y, Hoshi K, Ito H, Fuwa TJ, Yamaguchi Y, et al. Rapid increase of 'brain-type' transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery. J Biochem. 2018;164(3):205–13. https://doi.org/10.1093/jb/mvy043.

    CAS  Article  PubMed  Google Scholar 

  52. 52.

    de Die-Smulders CE, Howeler CJ, Thijs C, Mirandolle JF, Anten HB, Smeets HJ, et al. Age and causes of death in adult-onset myotonic dystrophy. Brain. 1998;121(Pt 8):1557–63.

    Article  Google Scholar 

Download references

Acknowledgements

We thank Xinying Chen for editing the English version of a draft of this manuscript.

Funding

The writing of the manuscript is financially supported by the Ministry of Science and Technology of the People’s Republic of China (2016YFC1306402), the Science Technology Department of Zhejiang Province (2017C03011), and the Medical Science and Technology Project co-founded by Zhejiang Province and the Ministry of Health of China (WKJ-ZJ-2024).

Author information

Affiliations

Authors

Contributions

JYW and ML are responsible for data collection, analysis, and for drafting and finalizing the manuscript. WJS and ZQC are responsible for data collection and analysis. GPP is responsible for revising the manuscript, analysis, and interpretation of data. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Guoping Peng.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, J., Liu, M., Shang, W. et al. Myotonic dystrophy type 1 accompanied with normal pressure hydrocephalus: a case report and literature review. BMC Neurol 20, 53 (2020). https://doi.org/10.1186/s12883-020-01636-0

Download citation

Keywords

  • Myotonic dystrophy (DM1)
  • Normal pressure hydrocephalus (NPH)
  • Genetic testing
  • Muscular dystrophy