Table 1 Previously published cases of Symplastic Hemangiomas and their Immuno-pathology

A tumor mass with capillary arteriovenous malformation for 1 year.

Nasopharyngeal

Female

12

Serbia

Samardzija et al.,

The pleomorphic cells in the vascular wall and interstitium were focally positive for SMA and scattered pleomorphic interstitial cells were CD68-positive. SMA, CD31 and CD34 positive in smooth muscle cells and endothelial cells. Endothelial cells were GLUT-1-negative. CD34 in pleomorphic cells was negative. Desmin staining was positive only in the vascular smooth muscle cells. Neither cell was stained with cytokeratin and S-100. Few pleomorphic interstitial cells were positive for CD163.

A polypoid tumor on the right thigh (duration unknown).

Cutaneous

Male

52

United Kingdom

Goh et al.,

Focal SMA positivity in the pleomorphic cells of the vascular walls. CD68 only weakly stained occasional atypical interstitial cells. The pleomorphic perivascular and interstitial stromal cells were negative for CD31, FLI-1, desmin, and S100. The vascular endothelial cells were positive for CD34, CD31, and FLI-1.

A polypoid skin lesion on right side of the nose for 20 years.

Cutaneous

Female

84

Goh et al.,

Focal SMA positivity in the pleomorphic cells of the vascular walls. In addition, focal strong staining for CD34 was seen in some stromal cells, particularly in the interstitial location. The pleomorphic perivascular and interstitial stromal cells were negative for CD31, FLI-1, desmin, and S100. The vascular endothelial cells were positive for CD34, CD31, and FLI-1.

Lenticular slightly protuberant reddish nodules located above the right scapula, for more than 5 years.

Cutaneous

Female

61

Germany

Kutzner et al.,

Only vimentin positive, SMA staining was weak in vessel walls pleomorphic nuclear cells. Cytokeratin, CD68, Factor VIIIa, and S100 were negative in vessel walls, epidermis, and cutaneous nerves.

Angiomatous nodule. on the extensor side of the left forearm for more than 1 decade.

Cutaneous

Male

63

Kutzner et al.,

Livid, dermatofibroma-like soft tumor over the extensor side of the right knee, existing for many years.

Cutaneous

Male

48

Kutzner et al.,

A segmental, superficial, infantile hemangioma on the forehead.

Cutaneous

Female

0.5

Chile

Downey et al.,

The pleomorphic vascular cells were focally positive for SMA and negative for desmin. Glut-1 was positive in the endothelial cells of the symplastic and precursor lesion.

A large intrathoracic mass occupying the right middle lobe of the lung (Suspicious of TB).

Intrathoracic

Male

31

Australia

Li et al.,

Stromal cells were negative for ERG, CD31 and CD34. Pleomorphic cells in the vessel walls were SMA positive, atypical stromal cells interstitium were positive for vimentin, and some were positive for SMA and CD68.

1-month history of swelling over the temporal region of the scalp.

Cutaneous

Male

57

Hong Kong, United Kingdom, and USA

Tsang et al.,

The vascular endothelial cells were positive for Factor VIIIa, Ulex europaeus lectin, CD31, and CD34.

A long-standing mass in the first web-space of the left hand,

Cutaneous

Female

65

Tsang et al.,

A large mediastinal mass discovered incidentally.

Mediastinum

Male

55

Tsang et al.,