- Case report
- Open Access
A unique case of multiple calvarial hemangiomas with one large symplastic hemangioma
BMC Neurology volume 21, Article number: 29 (2021)
Symplastic hemangioma is a benign superficial abnormal buildup of blood vessels, with morphological features which can mimic a pseudo malignancy. A few cases have been reported in the literature. We report here, a unique case of calvarial symplastic hemangioma, which is the first case in the calvarial region.
A 29-year-old male patient, with a left occipital calvarial mass since childhood, that gradually increased in size with age, was associated with recurrent epileptic fits controlled by Levetiracetam (Keppra), with no history of trauma. He presented to the emergency room with a recent headache, vomiting, frequent epileptic fits and a decrease in the level of consciousness 1 day prior to admission. A CT scan showed three diploic, expansile, variable sized lytic lesions with a sunburst appearance; two that were biparietal, and one that was left occipital, which were all suggestive of calvarial hemangiomas. However, the large intracranial soft tissue content, within the hemorrhage of the occipital lesion was concerning. The patient had refused surgery over the years; however, after the last severe presentation, he finally agreed to treatment.
The two adjacent, left parietal and occipital lesions were treated satisfactorily using preoperative embolization, surgical resection, and cranioplasty. Histopathology revealed cavernous hemangiomas, in addition to symplastic hemangioma (pseudo malignancy features) on top at the occipital lesion. The right parietal lesion was not within the surgical field; therefore, it was left untouched for follow-up.
Histopathology and radiology examinations confirmed the diagnosis as symplastic hemangioma, on top of a pre-existing cavernous hemangioma. To the best of our knowledge, this is the first case of a calvarial symplastic hemangioma, which we report here.
Intraosseous hemangioma is a rare bone neoplasm and accounts for < 1.0% of all bone tumors. They are usually found in the vertebral column and are rarely found in the calvarium [1, 2]. Calvarial hemangiomas are benign vascular malformations that account for approximately 0.2% of all bone tumors . Calvarial hemangiomas or cavernomas of the skull are termed intradiploic cavernomas, as they predominantly grow within the diploic space . Approximately 13% of calvarial lesions are hemangiomas, they are slow-growing, and benign. The majority of cases have been reported to contain a single lesion; however, the incidence of multifocal hemangiomas of the skull appears to be extremely rare [5,6,7,8]. They are usually asymptomatic, but may become symptomatic if they are large enough, with a compressing effect.
Symplastic hemangiomas have been described more recently, and the main features are degenerative pleomorphism, with atypia in the vascular smooth muscle and stromal interstitial cells in a pre-existing vascular lesion [9, 10]. In surgical pathology, the word ‘symplastic’ was used to describe the bizarre and multinucleated cell morphology, in the absence of other histological criteria of malignancy . Symplastic hemangioma is also a benign superficial, abnormal buildup of blood vessels, however its morphological features resemble with a malignant tumor. The distinctive lack of endothelial nuclear atypia allows it to be distinguished histologically from malignant vascular tumors. The symplastic type of hemangiomas has not been reported in the calvarial part of the skull so far. We present a case of multiple calvarial hemangiomas, with one large left occipital mass since childhood, which was rapidly growing and extending intracranially with a mass effect. Its final pathology was unexpectedly symplastic hemangioma, on pre-existing vascular lesions.
A 29-year-old male patient, with a left occipital calvarial palpable, hard, non-tender mass since childhood, that gradually increased in size with age, was associated with recurrent epileptic fits controlled by Levetiracetam, with no history of trauma. He presented in the emergency room (ER) with recent headache, vomiting, frequent epileptic fits, and a decrease in the level of consciousness 1 day prior to admission. He was vitally stable (GCS15/15) and afebrile, was able to move all of his limbs actively and was neurologically intact. Computed tomography (CT) of the brain revealed a left occipital and parietal hemangioma and he was admitted under the care of the neurosurgery team to be operated on.
A skull X-ray was not performed; however, the scout view of the preoperative CT scan showed parietal and occipital expansile lytic bony lesions, involving the inner and outer tables. The occipital lesion was larger, with internal trabeculations and a major intracranial part with spiculated margin (Fig.1). The CT scan showed three variable-sized, rounded, diploic, expansile, lytic lesions, with a sunburst appearance, thin walls and a thick trabecular appearance from the center (Fig.2a). There were two lesions at the bilateral parasagittal posterior parietal bones, measuring 20 and 12 mm in diameter, for the right and left, respectively, with the left one showing external wall erosion and mild subgaleal soft tissue (Fig.2b). In addition to the one large left parasagittal lesion, there was a left occipital bone lesion crossing the midline, measuring around 5 cm in diameter, with focal external wall erosion, internal wall defect and large epidural soft tissue. The cystic mass was compressing the adjacent occipital lobe and the occipital horn of the left lateral ventricle, and deviating the splenium of the corpus callosum to the right (Fig.3a). The soft tissue component was mildly hyperdense relative to the gray matter (Fig.3b).
The MRI showed hyperintensities on T1-weighted image (WI) and T2WI of the fat and vascular contents, respectively, and the post-contrast enhancement, without restricted diffusion, was suggestive of calvarial hemangiomas. The left high parietal lesion was compressed and invaded the superior sagittal sinus (Fig.4a). The largest left occipital lesion showed erosion of the skull, with large intracranial enhancing soft tissue mass of the hemorrhagic content (Fig.4b). The serial axial MRI T1 post-contrast images were captured in February 2017, January 2018 and April 2019, and showed progressive enlargement of the soft tissue component and increased mass effect (Fig.5a-c). In Fig.6a-e, the MRI images, T1WI, T2WI, FLAIR, Hemo, and post-contrast are shown; the left occipital lesion showed hyperintensities on T1WI/T2WI of the fat and vascular content, respectively (Fig.6a and b), it also compressed the adjacent occipital lobe without edema, deviated, anteriorly, the occipital horn of the left lateral ventricle, and obstructed the posterior aspect of the superior sagittal sinus (Fig.6c). The blooming effect on the hemorrhagic content was clear from the Hemo images (Fig.6d), and intense post-contrast enhancement (Fig.6e).
From the contrast-enhanced MR angiography, there were two tortuous arteries arising from the prominent left occipital artery (Fig. 7), providing a blood supply to the left occipital lesion. Contrast-enhanced MR venography revealed the absence of flow enhancement at the superior sagittal sinus by the right parasagittal parietal, left occipital lesions and prominent right veins of Labbe and Trolard. In addition, there was absence of flow enhancement at the left transverse dural sinus, with small left sigmoid dural sinus and internal jugular vein was observed (Fig.8a and b). The associated shallow left sigmoid groove, visualized on the CT scan (Fig.8c), may have either indicated chronicity and the result of the long-term effect of the left occipital lesion, or that it was not-related and could be congenital hypoplasia instead.
There was also an increased intracranial pressure evident by the empty Sella turcica and distended optic nerve sheaths on the MRI (Fig.9a and b). The neurosurgery team made the differential diagnosis of a diploic dermoid tumor.
Treatment and prognosis
Over the years the patient refused surgery; however, after the last severe presentation, he finally agreed to treatment. Based on the radiological report, cerebral angiogram and embolization of the feeders were performed to minimize the intraoperative bleeding (Fig.10a and b).
After 48 h, the patient underwent surgery. Considering that the outer palpable part of the mass was much less than the intracranial extension, it was adjacent to the diploic calcified mass and the bone had thickened, a craniectomy was planned over the adjacent left-sided parietal and occipital mass lesions, under general anesthesia. The head was fixed in the prone position, with the head fixed on a Mayfield head-holder. During the craniectomy, the involved bone was much thicker and was too hard (ivory-like); therefore, the neurosurgeon used numerous tools (a high-speed drill, a bone cutting nozzle of the ultrasonic aspirator, bone nibblers and a Kerrison rongeur) to perform the craniectomy. The part of the mass that was extending intracranially was firm with moderate vascularity and found to be eroding the dura and evaginating the brain tissue. However, there was a clear boundary, with an arachnoidal plane between the tumor and the brain tissue, that facilitated the separation of the tumor with complete excision and ensuring that the brain tissue was intact without violation. The two adjacent lesions were totally excised and hemostasis secured (Fig.11a). Dural grafting to seal the wide dural defect was achieved with the use of an artificial dural substitute (Duraform™). The bone defect was managed by the application of a Titanium mesh, with tiny screws. The scalp was healthy and closed in layers (Fig.11b). The right parietal small intradiploic lesion was outside of the surgical field; therefore, it was left untouched for follow-up.
Postoperatively, the patient recovered smoothly, was fully conscious, neurologically intact, feed orally and was discharged in a satisfactory condition. Superficial scalp wound infection was observed in the later stages, which was managed by broad-spectrum antibiotics. These wounds were completely healed, and became dry and clean. The patient had a normal life without recurrent symptoms, suggesting a compressive mass effect caused the fits. A follow-up CT brain scan after a few years and months revealed the atrophic left occipital lobe, with encephalomalacia and ex-vacue dilatation of the occipital horn of the left lateral ventricle (Fig.12).
Histopathology and immunology
Histopathology of the small left parietal lesion revealed cavernous hemangioma, while the left large occipital lesion showed a vascular lesion, with a thick wall and interstitial cells within a pre-existing vascular lesion. A microscopic examination revealed a well-defined lesion composed of variable sized dilated blood vessels, lined by endothelial cells exhibiting minimal nuclear atypia, with no multilayering or mitosis (Fig.13a and b). Vascular smooth muscle and stromal cells showed degenerative atypia, with enlarged hyperchromatic nuclei and multinucleation (Fig.13c). Lipoblast-like cells and scattered inflammatory cells in the background were also observed (Fig.13d). Focal vascular thrombosis and papillary endothelial hyperplasia were found. The stroma showed hemorrhage, edema and inflammatory cells. Immunohistochemistry data revealed positive staining for smooth muscle actin (SMA) in the pleomorphic cells (Fig.14a), CD68 showed weak staining in the stromal cells (Fig.14b), and CD34 was positively stained in the endothelial cells and some stromal cells (Fig.14c). Ki-67 proliferation index was < 1%.
Previously published cases of symplastic hemangiomas
In Table 1 we have summarized the previously published cases reports of symplastic hemangiomas and also the immuno-markers used to characterize these tumors. In the past 26 years, only eleven cases of symplastic hemangiomas have been published. The first three (one mediastinal and two cutaneous) cases were described in 1994 , another three cutaneous cases were reported in 2000 , then in 2006, Goh et al.,  reported two cutaneous cases; in 2018, a case of intrathoracic symplastic hemangioma ; also one case in the nasopharyngeal region in 2015 , and a case of infantile (symplastic) hemangioma was reported in 2019 . Our case report of calvarial symplastic hemangioma is the twelfth case report, and the first in the calvarial region.
Discussion and conclusions
Calvarial symplastic hemangioma, when compared with calvarial hemangiomas, is rarely reported in the literature. They are benign, slow-growing, malformed vascular lesions, often and incidentally discovered on radiological images obtained for other reasons. They account for < 1% of all primary bone neoplasms. Hemangiomas malignant degeneration has not been reported so far [17, 18]. Histologically, hemangiomas are classified according to the predominant type of vascular channel into four variants, cavernous, capillary, arteriovenous, and venous, and these variants are known to coexist [5, 19]. The cavernous type is predominant in hemangiomas of the skull .
The cavernous hemangiomas are characterized by the cluster of dilated blood vessels separated by fibrous septa. This is in contrast to capillary hemangiomas, which consist of small vascular lumens, without many fibrous septa. Cavernous hemangiomas are more common in the skull, whereas the capillary type is more common in the vertebral column [21, 22]. The pathogenesis of calvarial hemangiomas is not yet fully known; however, previous reports suggested that they are congenital [23,24,25]. The proliferation and differentiation of the undifferentiated primitive mesenchymal cells, induced by the various stimuli-like traumas, may be the potential etiology. Calvarial hemangiomas are common at the frontal bone, followed by the parietal and occipital bone and are rarely reported at the base of the skull [1, 20, 26]. Calvarial hemangiomas usually involve the outer table of the skull, and extensive involvement of the inner table and dura are typically rare . They are usually asymptomatic; however, they may become symptomatic if they are large enough, with a compressing effect . Neurological deficits are uncommon in calvarial hemangiomas, and seizures, as a presenting symptom, are unusual, whereas epileptic seizures are the most frequent symptom in patients with cerebral cavernous malformations , and epilepsy was reported in 65% cavernomas cases in the supratentorial region of the brain . Apart from our case, with a history of epilepsy, another case was reported with seizure disorder in calvarial hemangioma . In the present case, and also in the previously reported case, both the inner and outer tables of the skull were involved in causing a compression of the brain . Perhaps, when the tumor grew larger at a later stage, the tumor eroded the meninges and was in direct contact, resulting in the pressure on the brain tissue, which then caused it to behave like a meningioma, with recurrent fits. This may be the reason for the seizure disorder observed in both cases, due to this type of lesion growing slowly and the symptoms appearing after a prolonged period. The case report from Kanu et al.,  and our case demonstrates that seizure disorder can occur in calvarial hemangiomas, as a rare complication, likely due to a compression effect, as both patients were epilepsy-free after surgery.
From a CT scan, calvarial hemangioma is classically shown as an expansile lytic lesion, with the sclerotic rim of sunburst or a spoke wheel appearance of trabecular thickening radiating from a common center . Our present case showed the classic sunray appearance on tangential radiographs and a typical ‘sunburst pattern’ on CT bone window scans, which is a characteristic of calvarial hemangioma . Erosions of both internal or external plates can occur and may be associated with internal or external tumor expansion. Sometimes, bony trabeculae can grow beyond the cortical bone, and simulate an aggressive pseudo- “hair-on-end” periosteal reaction . From MRI, the signal intensity depends on the fat content, which is hyperintense on T1 and T2. The signal intensity increases with the post-contrast enhancement on CT and MRI. The present case was treated with preoperative embolization, surgical resection, and cranioplasty . Angiography is important for the embolization of feeders for large lesions to avoid intraoperative hemorrhage [34, 35].
As in our case, histopathology showed a symplastic hemangioma, within a pre-existing vascular tumor with minimal endothelial cell atypia, which can be suggested radiologically by the intracranial soft tissue content with hemorrhage. Immunohistochemistry showed focal positivity for SMA in the atypical cells, confirming a symplastic hemangioma, within a preexisting vascular lesion. CD34 antibody staining was performed to confirm the diagnosis and the endothelial cell lining of the vascular channels was found to be positive; thus, confirming our diagnosis. The distinctive lack of endothelial nuclear atypia allowed the distinction from malignant vascular tumors [10, 13,14,15,16]. Degenerative atypia of vascular smooth muscle and interstitial cells, mimicking a pseudo malignancy within a preexisting long-standing vascular lesion, with minimal endothelial cells atypia, is a main characteristic of symplastic hemangioma [10, 13]. Immunohistochemical stains showed that many of the pleomorphic cells in the vessel walls were SMA-positive, confirming them to be smooth muscle cells of the vascular media. To the best of our knowledge, this is the first case reported with symplastic hemangioma in the calvarial region.
In a unique case of a male patient, who underwent CT of the chest for a cough and night sweat symptoms, the CT scan showed a large intrathoracic mass in the right middle lobe of the lung, initially raising the suspicion of tuberculosis. This tumor resembled a mediastinal angiosarcoma, with histology features of a highly vascular nature of the lesion, with the focal areas of complex anastomosing vascular channels. However, careful histological and immunological investigations confirmed this case was symplastic hemangioma . Few previous reports of pathological cases masquerading as symplastic hemangiomas are also known. For example, differentiating multinucleate cell angio-histiocytoma (MCAH) from symplastic hemangioma is very difficult, as both of them share common histopathological features, such as the presence of vascular channels, bizarre cells, inflammatory stroma, and multinucleate giant cells mimicking a sarcoma . However, MCAH is more common in extremities, whereas symplastic hemangioma is common on the scalp and face. If the lesion is not present superficially, then there are more chances of misdiagnosis, as reported in the intrathoracic symplastic hemangioma case report .
Previously reported cases of skull base calvarial hemangiomas are rare. They occur most frequently in the vertebral column (30–50%) and the skull (20%), whereas the involvement of other sites, such as the long bones, short tubular bones, and ribs is uncommon. Calvarial hemangiomas are more common in females compared with that in males, with a 3:2 ratio, and usually affect individuals 20–40 years of age . In PubMed, 86 reports were found for a “calvarial hemangiomas” search, whereas a search for “symplastic hemangiomas” only revealed 8 reports published until now. The majority of the published symplastic hemangioma cases were of cutaneous origin [10, 12, 13, 16]; one case was intrathoracic in the mediastinum , another one was in the nasopharyngeal mucosa , and Xu et al.,  have reported a symplastic hemangioma case from China the location of this lesion is not known. The reported cases were also in middle-aged to the elderly, except one case of symplastic hemangioma, which was a pediatric infantile hemangioma arising over a skin lesion in a 6-month-old child , and the second pediatric case, of symplastic hemangioma was in the nasopharynx region arising extracutaneously over a capillary arteriovenous malformation . A rare case of symplastic trichodiscoma was also reported in a 50-year-old male, who presented with a nodule on the nose for 6 years. This case was reported to have histological features similar to ancient schwannoma and symplastic hemangioma . Trichodiscoma is a type of neurofollicular hamartoma, which is an abnormal malformation of the skin . The term “ancient schwannoma” is used to describe a schwannoma, with degenerative nuclear changes, that may be misinterpreted as a sarcomatous change .
Other large intra-diploic skull lesions to be considered in differential diagnosis of calvarial hemangioma include osteosarcoma, giant cell tumor (GCT), epidermoid cyst, and aneurysmal bone cyst (ABC). Although osteosarcomas are rarely affecting the skull, but they show sunburst appearance, and specular calcifications on CT Scan . The GCTs show marginal sclerosis and solid-cystic components indicating remodeling and destruction. On MRI, they show mixed density in both T1 and T2W images, and post contrast heterogenous enhancement . The intra-diploic epidermoid cysts are expansile lytic bony lesions with well-defined margins, and hypodense on CT scan [43, 44]. Radiographically, epidermoid cysts erode expanding into inner and outer tables of the calvaria. They show characteristic high signal on DWI MRI with no or minimal peripheral post contrast enhancement and no enhancement within the cyst . They are filled with debris (keratin and cholesterol) from the desquamation of their thin squamous epithelial lining, usually the cyst has a pearl-like appearance . The ABCs are commonly seen in younger age group, usually before the age of 20 years with characteristic “soap bubble-like” appearance for the multi-cystic mass on CT Scan with thinning of bony cortex with infrequent new bone formation around the lesions. On MRI, these lesions manifest with fluid-fluid levels and peripheral rim enhancement .
Overall, our case report has addressed calvarial symplastic hemangioma, which when compared to calvarial hemangiomas, is rarely reported in the literature. This has similar imaging features to calvarial hemangiomas, which classically show expansile lytic lesions with the sclerotic rim of sunburst or a spoke-wheel appearance on a CT scan. On MRI, the signal intensity depends on the fat, soft tissue and hemorrhagic content, and shows post-contrast enhancement. As in our case, a symplastic hemangioma can be suggested by a slow-growing soft tissue mass with hemorrhage in a pre-existing hemangioma. Symplastic hemangioma is a histopathological diagnosis, but radiology also confirmed this in our case. MRI was performed consecutively for 3 years, which showed progressive enlargement of the soft tissue component and increased mass effect in a pre-existing hemangioma.
Availability of data and materials
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
Aneurysmal bone cyst
Contrast-enhanced MR angiography
Contrast-enhanced magnetic resonance venography
External carotid artery
Formalin fixed paraffin embedded
Fluid attenuated inversion recovery
Glasgow coma scale
Giant cell tumor
- H and E:
Hematoxylin and eosin stain
Internal jugular vein
Multinucleate cell angio-histiocytoma
Maximum intensity projection
Magnetic resonance imaging
Non-enhanced computed tomography
Smooth muscle actin
Heckl S, Aschoff A, Kunze S. Cavernomas of the skull: review of the literature 1975-2000. Neurosurg Rev. 2002;25(1–2):56–62; discussion 66-67. https://doi.org/10.1007/s101430100180.
Ajja A, Oukacha N, Gazzaz M, Akhaddar A, Elmostarchid B, Kadiri B, Oukabli M, Boucetta M. Cavernous hemangioma of the parietal bone. A case report. J Neurosurg Sci. 2005;49(4):159–62 discussion 162.
Bastug D, Ortiz O, Schochet SS. Hemangiomas in the calvaria: imaging findings. Am J Roentgenol. 1995;164:683–7. https://doi.org/10.2214/ajr.164.3.7863894.
Martínez-Lage JF, Torroba M, Pérez BC, et al. Cavernous hemangioma of the cranial vault in infants: a case-based update. Child Nerv Syst. 2010;26(7):861–5.
Malde R, Moss T, Malcolm G, Whittlestone T, Bahl A. Multiple intraosseous calvarial hemangiomas mimicking metastasis from renal cell carcinoma. Adv Urol. 2008;2008:176392. https://doi.org/10.1155/2008/176392.
Kumar NA, Ranganadham P, Bhaskar G, Chowdhury AR. Multiple calvarial cavernous haemangiomas: case report and review of the literature. Neuroradiology. 1996;38(Suppl 1):S83–5. https://doi.org/10.1007/BF02278128.
Wyke DB. Primary hemangioma of the skull: a rare cranial tumor. Am J Roentgenol. 1949;61:302–16.
Thomas JE, Baker HL. Assessment of roentgenographic lucenies of the skull: a systematic approach. Neurology. 1975;25:99–106.
Goh SG, Calonje E. Cutaneous vascular tumours: an update. Histopathology. 2008;52(6):661–73. https://doi.org/10.1111/j.1365-2559.2007.02924.x.
Goh SG, Dayrit JF, Calonje E. Symplastic hemangioma: report of two cases. J Cutan Pathol 2006: 33:735–740.doi : https://doi.org/10.1111/j.1600-0560.2006.00552. x.
Downes KA, Hart WR. Bizarre leiomyomas of the uterus. A comprehensive pathologic study of 24 cases with long-term follow-up. Am J Surg Pathol. 1997;21(11):1261.
Tsang WYW, Chan JKC, Fletcher CDM, et al. Symplastic hemangioma: a distinctive vascular neoplasm featuring bizarre stromal cells. Int J Surg Pathol. 1994;1(3):202.
Kutzner H, Winzer M, Mentzel T. Symplastic hemangioma. Hautarzt. 2000;51(5):327–31. https://doi.org/10.1007/s001050051126.
Li JJ, Kim L, Henderson C. A case of intrathoracic symplastic haemangioma could have been misdiagnosed as angiosarcoma. Pathology. 2018;50(6):688–91. https://doi.org/10.1016/j.pathol.2018.03.013.
Samardzija G, Djuricic SM, Baljosevic I, Calonje E. Nasopharyngeal capillary Arteriovenous malformation with ancient/Symplastic change: a simulator of malignancy. Pediatr Dev Pathol. 2016;19(3):249–53. https://doi.org/10.2350/14-09-1547-CR.1.
Downey C, Pino G, Zambrano MJ, Kramer D, Cervilla K, González S. Symplastic hemangioma developing over an infantile hemangioma during propranolol treatment. Pediatr Dermatol. 2019;36(6):961–2. https://doi.org/10.1111/pde.13960.
Prasanna GV, Katari UK, Vandanapu SK, Reddy MS, Adusumilli HB. Giant Calvarial cavernous Hemangioma: a rare case report and review of literature. Asian J Neurosurg. 2019;14(2):578–80. https://doi.org/10.4103/ajns.AJNS_260_18.
Khanam H, Lipper MH, Wolff CL, Lopes MB. Calvarial hemangiomas: report of two cases and review of the literature. Surg Neurol. 2001;55(1):63–7; discussion 67. https://doi.org/10.1016/s0090-3019(00)00268-8.
Patten DK, Wani Z, Kamineni S. Intramuscular cavernous haemangioma of the triceps. Int J Surg Case Rep. 2011;2:86–9.
Kirmani AR, Sarmast AH, Bhat AR. A unique case of calvarial hemangioma. Surg Neurol Int. 2016;7(Suppl 14):S398–401. Published 2016 Jun 3. https://doi.org/10.4103/2152-7806.183498.
AlMakadma Y, Alkhani AM. Diffuse calvarial cavernoma: case report and review of the literature. Childs Nerv Syst. 2013;29:1047–9. https://doi.org/10.1007/s00381-013-2079-7.
Rumana M, Khursheed N, Farhat M, Othman S, Masood L. Congenital intraosseous cavernous hemangioma of the skull: an unusual case. Pediatr Neurosurg. 2013;49(4):229–31. https://doi.org/10.1159/000363328.
Yoshida D, Sugisaki Y, Shimura T, et al. Cavernous hemangioma of the skull in a neonate. Childs Nerv Syst. 1999 Jul;15(6–7):351–3. https://doi.org/10.1007/s003810050410.
Vural M, Acikalin MF, Adapinar B, et al. Congenital cavernous hemangioma of the calvaria. Case report J Neurosurg Pediatr. 2009;3(1):41–5. https://doi.org/10.3171/2008.10.PEDS08161.
Brichacek M, Naeem A, Filler G, Hammond R, Yazdani A, Ranger A. Congenital Calvarial Hemangioma. J Craniofacial Surg. 2018;29(6):1625. https://doi.org/10.1097/SCS.0000000000004613.
Nair P, Srivastava AK, Kumar R, Jain K, Sahu RN, Vij M, Jain M. Giant primary intraosseous calvarial hemangioma of the occipital bone. Neurol India. 2011;59(5):775–6. https://doi.org/10.4103/0028-3886.86568.
Rosenow F, Alonso-Vanegas MA, Baumgartner C, et al. For the surgical task force, commission on therapeutic strategies of the ILAE. Cavernoma-related epilepsy: review and recommendations for management—report of the surgical task force of the ILAE commission on therapeutic strategies. Epilepsia. 2013;54(12):2025–35. https://doi.org/10.1111/epi.12402.
Moran NF, Fish DR, Kitchen N, et al. Supratentorial cavernous haemangiomas and epilepsy: a review of the literature and case series. J Neurol Neurosurg Psychiatry. 1999;66:561–8.
Kanu OO, Ojo OA, Bankole O, Olaniran A, Anunobi C, Arigbabu SO. Calvarial hemangioma causing seizure disorder: A case report with review of literature. Romanian Neurosurg. 2012;XIX 2:120–3.
Garfinkle J, Melançon D, Cortes M, Tampieri D. Imaging pattern of calvarial lesions in adults. Skelet Radiol. 2011;40:1261–73.
Prasad SN, Chaudhary U, Kumari M, Lal H. Giant calvarial haemangioma with classical radiological features. BMJ Case Rep. 2017;2017. https://doi.org/10.1136/bcr-2017-223029.
Pons Escoda A, Naval Baudin P, Mora P, et al. Imaging of skull vault tumors in adults. Insights Imaging. 2020;11(1):23. Published 2020 Feb 13. https://doi.org/10.1186/s13244-019-0820-9.
Colas L, Caron S, Cotten A. Skull vault lesions: a review. AJR Am J Roentgenol. 2015 Oct;205(4):840–7. https://doi.org/10.2214/AJR.14.13415.
Liu JK, Burger PC, Harnsberger HR, Couldwell WT. Primary Intraosseous Skull Base cavernous Hemangioma: case report. Skull Base. 2003;13(4):219–28. https://doi.org/10.1055/s-2004-817698.
Schneider RC, Gabrielsen TO, Hicks SP. Calvarial hemangioma; the value of selective external carotid angiography in surgical excision of the lesion. Neurology Apr. 1973;23(4):352. https://doi.org/10.1212/WNL.23.4.352.
Sinhasan SP, Sylvia MT, Sangma MM, Bhat RV. Multinucleate cell angiohistiocytoma versus symplastic hemangioma - diagnostic dilemma. CLIN Cancer Investig J. 2015;4:741–4.
Xu S, Yu L, Wang J. Symplastic hemangioma: report of a case. Zhonghua Bing Li Xue Za Zhi. 2013;42(8):554–5. 24246925.
Battistella M, Eeckhout PV, Cribier B. Symplastic Trichodiscoma: a spindle-cell predominant variant of Trichodiscoma with Pseudosarcomatous/ancient features. Am J Dermatopathol. 2011;33:e81–3. https://doi.org/10.1097/DAD.0b013e3182181325.
Kutzner H, Requena L, Ru¨tten A, et al. Spindle cell predominant trichodiscoma: a fibrofolliculoma/trichodiscoma variant considered formerly to be a neurofollicular hamartoma: a linicopathological and immunohistochemical analysis of 17 cases. Am J Dermatopathol. 2006;28:1–8.
Bindra R, Gupta S, Gupta N, et al. Ancient schwannoma of the neck mimicking soft tissue sarcoma. J Cancer Res Ther. 2010;6:234–5.
Kanazawa R, Yoshida D, Takahashi H, Matsumoto K, Teramoto A. Osteosarcoma arising from the skull--case report. Neurol Med Chir (Tokyo). 2003;43(2):88–91. https://doi.org/10.2176/nmc.43.88 PMID: 12627887.
Ayberk G, Adiloglu SI, Yazgan AK, Ferhat M, Ozveren MF. A Giant Cell Granuloma of the Temporal Bone: A Case Report. ClinMed Case Rep Neurosurg Cases Rev. 1:002. https://doi.org/10.23937/ncr-2017/1710002.
Krupp W, Heckert A, Holland H, et al. Giant intradiploic epidermoid cyst with large osteolytic lesions of the skull: a case report. J Med Case Rep. 2012;6:85. https://doi.org/10.1186/1752-1947-6-85.
Kumaran SP, Gupta K, Priyadarshini H, Ghosal N. Giant Intradiploic Epidermoid cyst of occipital bone. A case report and literature review. Neuroradiol J. 2010;23:707–10.
Oommen A, Govindan J, Peroor DS, Azeez CR, Rashmi R, Abdul Jalal MJ. Giant Occipital Intradiploic Epidermoid Cyst. Asian J Neurosurg. 2018;13:514–7. https://doi.org/10.4103/1793-5482.181146.
Yılmaz B, Ekşi MŞ, Akakın A, Kılıç T. A burning candle in the dark night-incidental intradiploic epidermoid cyst of occipital bone. J Neurosci Rural Pract. 2016;7(1):181–2. https://doi.org/10.4103/0976-3147.172160.
Lee Y-C, Ho J-T, Lin W-C, Lui CC. Aneurysmal bone cyst of skull base: a case report and review of literature. Chin J Radiol. 2010;35:33–8.
All authors have approved the manuscript for submission. The content of the manuscript has not been published, or submitted for publication elsewhere. The authors wish to thank Mrs. Hatoon Mohammed Badaawood of Histopathology Laboratory, and Mr. Mohammed Alzahrani MRI technician of Department of Radiology, at Al- Noor Specialist Hospital Makkah, for their technical support.
This study is supported by a grant from The Deanship of Scientific Research, Umm-Al-Qura University, Makkah to Dr. MM. Taher (Code. No. 43509008).
Ethics approval and consent to participate
The present study was approved by the Institutional Review Board (IRB) for Bioethics Committee of the King Abdullah Medical City (IRB no. 14–140) and performed in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from the patient prior to the study.
Consent for publication
Written informed consent was obtained from the patient for publication of their individual details and accompanying images in this manuscript.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
About this article
Cite this article
Bantan, N.A.A., Abouissa, A.H., Saeed, M. et al. A unique case of multiple calvarial hemangiomas with one large symplastic hemangioma. BMC Neurol 21, 29 (2021). https://doi.org/10.1186/s12883-021-02053-7
- Calvarial hemangioma
- Symplastic hemangioma
- Dural sinus
- Preoperative embolization
- Surgical resection
- Saudi Arabia